Liposome-based high-throughput and point-of-care assays toward the quick, simple, and sensitive detection of neutralizing antibodies against SARS-CoV-2 in patient sera.

The emergence of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) in 2019 caused an increased interest in neutralizing antibody tests to determine the immune status of the population. Standard live-virus-based neutralization assays such as plaque-reduction assays or pseudovirus neutralization tests cannot be adapted to the point-of-care (POC). Accordingly, tests quantifying competitive binding inhibition of the angiotensin-converting enzyme 2 (ACE2) receptor to the receptor-binding domain (RBD) of SARS-CoV-2 by neutralizing antibodies have been developed.

Printable 3D Carbon Nanofiber Networks with Embedded Metal Nanocatalysts.

Carbon nanofiber (CNF) nanocatalyst hybrids hold great promise in fields such as energy storage, synthetic chemistry, and sensors. Current strategies to generate such hybrids are laborious and utterly incompatible with miniaturization and large-scale production. Instead, this work demonstrates that Ni nanoparticles embedded in three-dimensional (3D) CNFs of any shape and design can be easily prepared using electrospinning, followed by laser carbonization under ambient conditions.