Management and outcome of multifetal gestation in a 35-year-old woman with childhood-onset membranoproliferative glomerulonephritis type I.

A 35-year-old woman with membranoproliferative glomerulonephritis type I had quintuplet gestation after induced ovulation. Her serum creatinine level and estimated glomerular filtration rate were 0.86 mg/dL and 61.

Long-term prognosis of 4 children with steroid-sensitive nephrotic syndrome and relapse after 30 years of age.

Some children with steroid-sensitive nephrotic syndrome (SSNS) have been reported to suffer relapses in adulthood, but the clinical course of such adults is unclear. Four children with SSNS suffered relapses after 30 years of age. Those 4 patients developed frequently relapsing nephrotic syndrome (NS) between 2 and 10 years of age.

Pregnancy in 4 women with childhood-onset steroid-sensitive nephrotic syndrome.

Four women with childhood-onset steroid-sensitive nephrotic syndrome (SSNS) had 5 pregnancies. Their age at onset of SSNS was between 4 and 10 years, and age at pregnancy was between 21 and 31 years. Three patients with frequent relapsing nephrotic syndrome (NS) continued to relapse after 20 years of age.

A girl with Peters plus syndrome associated with myelomeningocele and chronic renal failure.

A girl was born with sclerocornea of the right eye, corneal staphyloma of the left eye and lumbar myelomeningocele. The myelomeningocele was repaired soon after birth. The corneal staphyloma was perforated during infancy.

A male patient with malignant lymphoma and thyroid papillary carcinoma after pediatric renal transplantation.

A 6-year-old boy received renal transplantation and was treated with methylprednisolone, cyclosporine A and mizoribine. He developed Epstein-Barr virus-associated malignant lymphoma at 10 years and thyroid papillary carcinoma at 20 years of age. Chemotherapy for the malignant lymphoma was done after withdrawal of cyclosporine A and mizoribine, and thyroidectomy was performed for thyroid carcinoma.

A boy with membranous nephropathy after allogeneic bone marrow transplantation.

A 6-year-old boy developed bronchiolitis obliterans organizing pneumonia and nephrotic syndrome 5 months after allogeneic bone marrow transplantation from an unrelated donor for acute lymphoblastic leukemia. His renal biopsy showed membranous nephropathy. He was treated with prednisolone and cyclosporine A.

Head circumference and development in young children after renal transplantation.

Background: Growth impairment, microcephaly and developmental delay in young children with chronic renal failure improve after successful renal transplantation. There have been few reports on head circumference (HC) and development after transplantation.

Method: Standard deviation scores (SDS) of height and HC and developmental quotient (DQ) after successful renal transplantation were evaluated in 12 recipients under 5 years of age.

Steroid-sensitive nephrotic syndrome in two families.

Few reports of familial cases of steroid-sensitive nephrotic syndrome (SSNS) are available. Of 123 children with SSNS, four cases in two families are presented. Two sisters and a father and his daughter developed SSNS.

Membranoproliferative glomerulonephritis in a girl and her mother.

A girl and her mother were diagnosed as having membranoproliferative glomerulonephritis (MPGN) type I. Microscopic hematuria and proteinuria presented at 9 years of age in the mother and at 14 years in the daughter. Both had persistent hypocomplementemia and were treated with steroids.

Transition of children with membranoproliferative glomerulonephritis to adolescence and adulthood.

Background: Many chronic renal diseases in children, including membranoproliferative glomerulonephritis (MPGN), often continue into adulthood, and these patients require continuing management. Despite the importance of the topic, there has been limited discussion about the problems of transition in children with continuing renal disease. We report our experience in patients with MPGN, as they matured from childhood to adolescence and adulthood, so-called "carry-over" cases.

IgA nephropathy associated with leukemia and lymphoma: report of two cases.

IgA nephropathy (IgAN) associated with leukemia and lymphoma has not, to our knowledge, been reported in children. Two children suffering from these diseases are described here. One patient developed IgAN at the end of 5 years' chemotherapy for acute lymphocytic leukemia.

Adult height of three renal transplant patients after growth hormone therapy.

Three girls with normal growth hormone secretion had received renal transplantation when aged 2 to 6 years. They had had severely retarded growth (SD for height score was -7.4 to -3.

Final height in children with steroid-sensitive nephrotic syndrome.

Background: Growth retardation following steroid treatment in children is a major problem. Reduction of steroid dose has been tried using immunosuppressive agents such as cyclosporine A or mizoribine in children with frequently relapsing nephrotic syndrome. Few reports concerning final height in steroid-sensitive nephrotic syndrome (SSNS) are available.

Familial cases of Henoch-Schönlein purpura in eight families.

Background: Familial cases of Henoch-Schönlein purpura (HSP) have rarely been reported.

Methods: Familial cases of HSP were reviewed by medical records of 418 children with HSP.

Results: Two members developed HSP in eight families.

Clinical course of congenital nephrotic syndrome and Denys-Drash syndrome in Japan.

Background: The prognosis of Japanese patients with congenital nephrotic syndrome (CNS) and Denys-Drash syndrome (DDS) is not clear.

Methods: Five patients with CNS and four patients with DDS, which causes secondary CNS, were studied retrospectively.

Results: Seven patients were sporadic and two DDS patients were identical twins.

Hypocomplementemia and membranoproliferative glomeruloneophritis in children.

Background: The incidence of hypocomplementemia detected in the school urinary screening program in Kanagawa Prefecture, Japan, and the number of new patients with membranoproliferative glomerulonephritis (MPGN) diagnosed in our institution were decreasing during the period between 1974 and 1997. Follow-up of this study was performed during the period between 1998 and 2003.

Methods: A total of 1,230,398 urine specimens in elementary and junior high school were examined between 1980 and 2003.

Henoch-Schonlein purpura with hypocomplementemia in children.

Background: The clinical course and prognosis of Henoch-Schonlein purpura (HSP) associated with hypocomplementemia are not clear.

Methods: The clinical findings of 10 children with HSP and hypocomplementemia were studied.

Results: Purpuric rash in all patients, abdominal pain in five, and arthralgia in nine were noted.

Acute glomerulonephritis in three siblings and suspected emm49-type Streptococcus pyogenes infection.

Three siblings with poststreptococcal acute glomerulonephritis are presented. Streptococcal infection, impetigo, and pharyngitis preceded the acute glomerulonephritis. In one patient, emm49-type Streptococcus pyogenes was isolated, a strain which has not been reported as nephritogenic in Japan.

A male patient with steroid-dependent nephrotic syndrome for 25 years and obesity-associated focal segmental glomerulosclerosis.

An obese male patient with steroid-dependent nephrotic syndrome since age 6 years had a thirty-third relapse at the age of 29 years. Renal biopsy showed focal segmental glomerulosclerosis. Proteinuria disappeared after treatment with prednisolone.

Two cases of congenital nephrotic syndrome.

The clinical course and renal histological changes in two patients with congenital nephrotic syndrome are presented. Both patients developed edema and proteinuria at 2 days of age. Steroids and immunosuppressive drugs were not used in either patient.

IgA-associated glomerulonephritis with membranoproliferative glomerulonephritis-like pattern in two children.

In this article, we report two patients with IgA-associated glomerulonephritis with a membranoproliferative glomerulonephritis (MPGN) -like pattern. Both patients had nephrotic syndrome at onset. One patient was treated with high-dose alternate-day prednisolone (PSL), and the other with indomethacin and low-dose PSL.

Long-term follow-up of type II membranoproliferative glomerulonephritis in two children.

We report the long-term follow-up of two patients with type II membranoproliferative glomerulonephritis (MPGN). One Patients was treated with high-dose alternate-day prednisolone and the other with dipyridamole. Both had favorable clinical courses over 8.