Effects of irbesartan on 24-h blood pressure changes and urinary albumin levels in Japanese outpatients.

In Japan, ambulatory blood pressure monitoring (ABPM) became covered by health insurance in April 2008. In The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH2009), the importance of 24-h blood pressure monitoring was also described in an additional section. Therefore, ABPM may be increasingly applied in hypertension treatment.

Inhibition of Alzheimer amyloid aggregation with sulfated glycopolymers.

Glycopolymers carrying sulfated saccharides with modest sugar contents (11% and 28%) were found to suppress the formation of amyloid fibrils by amyloid beta peptides (Abeta(1-42), Abeta(1-40), and Abeta(25-35)), as evaluated by thioflavin T assays and atomic force microscopy observation. Circular dichroism spectra showed that the conformation of amyloid beta peptides depended on the glycopolymer additives, and that the glycopolymer additives reduced the beta-sheet contents. Neutralization activity was confirmed by in vitro assay with HeLa cells.