[Comparative effectiveness of various methods of surgical, combined and comprehensive treatment of patients with colonic cancer].

The results of radical treatment of cancer recti using surgical and combined methods, which had envisaged application of preoperative irradiation, systemic chemotherapy with the add of fluorouracil and calcium folinate, intraarterial polychemotherapy with the help of fluorouracil, adriablastinum on background of verapamil, endolymphatic polychemotherapy with local hyperthermy of ultra-high frequency, intraoperative intraperitoneal polychemotherapy and autoimmunotherapy with application of antitumoral vaccine. After application of autoimmunotherapy, endolymphatic polychemotherapy, preoperative intensive gamma-therapy in combined treatment of patients with cancer recti II-III stages the indexes of five-year survival had improved.

[Primary multiple malignant tumors of the stomach and colon].

Experience of diagnosis and treatment of primarily-multiple gastric cancer, combined with malignant colonic tumors in 27 patients was summarized. One-stage combined radical treatment of the patients is the most effective one.

[Immediate and early results of combined treatment of colonic cancer using neoadjuvant selective intra-arterial polychemotherapy].

The combined treatment of 53 patients with colonic cancer, using neoadjuvant intraarterial polychemotherapy (IAPCT), was conducted. The trustworthy lowering of the catheterized artery thrombosis occurrence rate, the tumor recurrence-by 7%, distant metastases-by 13.9%, two-year survival increase-by 15.

[The use of neoadjuvant selective intra-arterial polychemotherapy and its modifier verapamil in the combined treatment of colorectal cancer].

After combined treatment of 74 patients for colorectal cancer using preoperative neoadjuvant intraarterial selective polychemotherapy (IAPCT) three-year survival index have constituted (77.0 +/- 5.2)%, the cancer recurrence have occurred in (10.

Neoadjuvant intra-arterial polychemotherapy of locally advanced rectal cancer.

In order to evaluate the usefulness of pre-operative intra-arterial selective polychemotherapy (PIASP), we carried out a retrospective study of 107 patients (65 males, 42 females) with locally advanced rectal cancer (LARC) (pT3-4 N0-1 M0), who were treated between 1988 and 1991. Fifty-two patients (MG) underwent PIASP (Adriablastin 60-90 mg, fluorouracil 3-4 g) with subsequent radical surgery. Fifty-five patients (R0) received surgery alone.

[The role of the "milk" factor in the transmission of Campylobacter infection].

The epidemiological survey of the foci of campylobacteriosis confirmed the activity of the "milk" factor in the transmission of this enteric infection. The proliferation of Campylobacter in milk corresponded to the general regularities of the growth of bacterial population in the closed system. Most of the Campylobacter strains under study retained their viability in cooled boiled milk for a longer time.

[Current parameters of the epidemiological process in campylobacteriosis].

Data on some parameters of the epidemic process of campylobacteriosis in the Ukraine are presented. Campylobacteriosis patients were found to constitute 1.9 +/- 0.

[The cytopathogenic activity of Campylobacter isolated from different sources].

The data on the cytopathogenic activity of campylobacteria isolated from different sources are presented. 84.7 % of the isolated campylobacteria have been shown to possess cytopathogenicity with respect to Hep-2 cell cultures.

[The characteristics of the epidemiology of campylobacteriosis under modern conditions].

The results of the clinico-epidemiological study of campylobacteriosis in a concrete area (Kiev and the Kiev region) are presented. The proportion of campylobacteriosis cases was found to be 6.4% among patients hospitalized in connection with acute enteric infections.

[The antibiotic resistance of strains of Campylobacter of different origins].

Antibioticograms of different campylobacteria strains have been analyzed. It is shown possible to develop a system of epidemiological marking on this basis. With this purpose sensitivity of campylobacteria to gentamycin, canamycin, carbenicyllin, tetracylin and erythromycin has been studied.

[The effect of the multiyear agricultural use of animal husbandry wastes on the infectious morbidity of the local population].

The report presents results of study of relationship between the longterm practice of utilization of waste matter from livestock industry (solid, liquid portions of manure, redundant active silt) in the crop-growing of the steppe, forest-steppe zones as well as of those of woodlands in Ukraine, on the incidence of acute infective diseases of the intestine in the community. The soil of farm lands was found out to be affected by an extensive bacterial contamination due to the above wastes being utilized on a wide scale. The degrees of risk of acute intestinal infection morbility in population areas located in those zones having utilization fields, are significantly higher than beyond their bounderies.

[The fatty acid composition of the total lipids in bacteria of the genus Campylobacter].

Composition of fatty acids of total lipids in home strains of campylobacteria has been studied. Lipids of all the strains of C. jejuni and C.

[The immediate results of the combined treatment of rectal cancer using intra-arterial selective polychemotherapy].

The treatment experience of 127 patients with the locally spread rectal cancer was summarized. The combined with preoperative intraarterial chemotherapy course application causes significant injurious effect on the tumor (more than 3 times decrease of the viable tumor tissue part by volume in rectal adenocarcinoma, the appearance of subcapsular necrosis regions in metastatically injured regional lymphatic nodes in 32.2% of observations) and is characterized by low common toxicity.

[Endolymphatic polychemotherapy with local ultra high frequency hyperthermia for the combined treatment of invasive rectal cancer].

The results of treatment of diffuse forms of rectal cancer with the use of a preoperative course of endolymphatic polychemotherapy (fluorouracil and platidiam) and local SHF-hyperthermia are presented. The most pronounced effect of treatment was noted in patients with metastases to the regional lymph nodes. The method suggested is effective in treatment of all the types of adenocarcinoma.

[Multiple primary malignant neoplasms of the large intestine].

Of the 3182 patients with malignant tumors of the large intestine, in 140 (4.4%), the primary multiple malignant neoplasms were revealed: in 59 (42.1%) of them--the synchronous, in 81 (57.

[Combined surgical interventions in disseminated forms of rectal cancer].

Combined operative interventions were performed in 375 (14.6%) out of the 2564 patients operated on radically. In 10 patients, evisceration of the pelvic organs was performed.

[Peculiarities of diagnosis and treatment of initial forms of rectal cancer].

Of 3185 patients, the stage I rectal cancer was diagnosed in 220 (6.9%), stage II--in 156 (4.9%), stage III--in 1948 (61.

[Conservative surgery in the initial forms of cancer, malignant adenomas and villous tumors of the rectum].

The results of sparing transanal operations performed in 519 patients with the early forms of cancer, malignant adenomas and villous tumors of the rectum are presented. On the basis of studying the five- and ten-year survival, it is shown that local sparing operations provide stable and prolonged cure of the patients. The dependence between recurrence of adenomas, peculiarities of their macro- and microscopic structure has been traced.

[Nonspecific active stimulation of the immune system in the combined treatment of rectal cancer].

Results of investigations on the efficacy of splenin as an immunomodulator in the complex treatment of 70 patients with cancer of the rectum revealed its favourable effect on the T- and B-systems of immunity. It was found that immunotherapy effected favourably the immunological properties of the body and this was also supported by clinical data. This makes it possible to recommend splenin as in immunomodulator in the complex treatment of patients with cancer of the rectum.

[Clinico-morphologic aspects of the combined treatment of locally disseminated cancer of the rectum].

In 1174 patients, the pathomorphosis of rectal cancer conditioned by the combined treatment with preoperative irradiation was studied. Preoperative radiotherapy caused considerable disorders in the morphologic structure of a tumour. The survival of patients and incidence of tumour recurrences, depending on the pronouncement of morphologic changes after radiotherapy, were studied.

[Means of improving the efficacy of the treatment of cancer of the rectum (experience in the surgical and combination treatment of 3185 patients)].

The analysis of the results of surgical and combined treatment of 3185 patients with rectal cancer was carried out. Of these patients, 88.2% were operated on at the stages III and IV of the disease.