Publications by authors named "Kiki Seo"
Article Synopsis
- MraY inhibitory natural products are promising candidates for new antibacterial treatments, especially against drug-resistant bacteria, but improving their properties through chemical modifications is challenging due to complex synthesis processes.
- A new strategy has been developed to efficiently create and evaluate a library of 686 MraY analogue compounds, allowing for streamlined preparation and direct assessment of their biological activities.
- This research identifies several potent analogues that are effective against drug-resistant strains and reveals unique binding patterns with MraY, while also demonstrating the method's applicability to other natural products targeting tubulin activities.
Scope: Diallyl trisulfide (DATS), an organosulfur compound generates in crushed garlic, has various beneficial health effects. A growing body of evidence indicates that miRNAs are involved in the pathology of lifestyle diseases including obesity. The anti-obesogenic effect of garlic is previously reported; however, the effects of DATS on obesity, and the relationship between garlic compounds and the involvement of miRNA remains unclear.
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