Publications by authors named "Kihyun Cho"

Article Synopsis
  • African swine fever (ASF) is a deadly disease in pigs, and the first ASF virus isolate from Korea was used to study how the disease spreads through different infection routes.* -
  • In experiments, pigs were infected through intraoral, intranasal, and intramuscular methods, with all methods showing similar disease progression, whereas pigs exposed through direct contact showed comparable symptoms after a 7-day latency.* -
  • The severity of symptoms varied between infection routes, suggesting that the intramuscular route isn’t ideal for understanding ASF virus mechanisms, while intraoral and intranasal routes are better suited for vaccine and pathogenicity studies.*
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  • - Since the first African swine fever (ASF) outbreak in South Korea in September 2019, there have been 31 cases on pig farms and nearly 2800 infected wild boars detected by January 2023, indicating a high risk of the virus spreading to domestic pigs.
  • - Despite concerns about the pathogenicity of ASFV strains, a previous study found no changes in virulence from 2019 to 2021; this new research aimed to investigate strains from 2022 to early 2023 for possible alterations.
  • - The study identified two ASFV strains with potentially reduced pathogenicity, but all pigs inoculated with these strains died 8-10 days later, showing consistent symptoms and lesions, suggesting that
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  • Fifteen pig farms in South Korea were impacted by African swine fever (ASF) from 2022 to April 2023, prompting genetic analysis of the virus.
  • The study identified that all 15 viral strains fell under p72 genotype II and CD2v serogroup 8, with most containing intergenic region II variants and an additional tandem repeat sequence.
  • Unique genetic variations included a single-nucleotide polymorphism found in six strains and indicated that the ASF virus sources at these affected farms were distinct from those at other farms.
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Redox-mediated electrosorption is a promising platform for selective electrochemical (EC) separations, due to its molecular selectivity, high uptake, and tunability for target ions. However, the electrical energy required is mainly generated by non-renewable energy sources, which limits its sustainability and overall impact to decarbonization. Here, a redox-mediated photoelectrochemical (PEC) separation process using polyvinyl ferrocene functionalized TiO nanorod electrodes is proposed, which integrates direct solar energy as a driver for the selective electrosorption.

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In recent years, polymer-based tissue adhesives (TAs) have been developed as an alternative to sutures to close and seal incisions or wounds owing to their ease of use, rapid application time, low cost, and minimal tissue damage. Although significant research is being conducted to develop new TAs with improved performances using different strategies, the applications of TAs are limited by several factors, such as weak adhesion strength and poor mechanical properties. Therefore, the next-generation advanced TAs with biomimetic and multifunctional properties should be developed.

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Since 2018, Asian countries have been affected by the African swine fever (ASF) virus, with major socioeconomic consequences. Moreover, the number of people traveling in Asian countries has been increasing, leading to an inevitable increase in the risk of ASF spread through livestock products carried by travelers. China and South Korea have close geo-economic ties and numerous international travelers.

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  • * It will involve 4,806 participants in a multicenter, randomized, open-label trial, comparing the outcomes of 12 months of DAPT versus 3 months followed by monotherapy for the next 9 months.
  • * The primary outcome measures include the occurrence of strokes, heart attacks, and overall mortality over one year, while major bleeding events will be monitored as the primary safety concern.
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African swine fever virus (ASFV) causes African swine fever (ASF), a deadly disease affecting both domestic pigs and wild boars. ASF has become endemic in Vietnam since its first appearance in early 2019. Our previous molecular surveillance studies revealed that all the ASFV strains circulating in Vietnam belong to p72 genotype II, p54 genotype II, CD2v serogroup 8, and CVR of B602L gene variant type I.

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Background: Whether deep learning models using clinical data and brain imaging can predict the long-term risk of major adverse cerebro/cardiovascular events (MACE) after acute ischaemic stroke (AIS) at the individual level has not yet been studied.

Methods: A total of 8590 patients with AIS admitted within 5 days of symptom onset were enrolled. The primary outcome was the occurrence of MACEs (a composite of stroke, acute myocardial infarction or death) over 12 months.

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  • Between 2019 and 2021, 21 farms in South Korea were confirmed to be infected with African swine fever (ASF), with viruses examined from blood and spleen samples for genetic analysis.
  • The phylogenetic study showed that all strains belonged to p72 genotype II and serogroup 8, with specific genetic features including the intergenic region II variant and a consistent central variable region.
  • Notably, while most strains were identical to others found in Georgia and China, the 18th isolate displayed a unique mutation with three nucleotide insertions, indicating it might be a distinct variant compared to the other infections.
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  • African swine fever (ASF) was first identified in South Korea in 2019, with reports of 21 domestic pig cases and 1,875 infected wild boars by the end of 2021.
  • Researchers experimented with four different ASF virus strains from domestic pigs between 2019 and 2021 to assess their virulence in pigs.
  • All infected pigs succumbed to the disease within 4-9 days, displaying severe clinical symptoms and necropsy findings, confirming that the virulence of the ASFV strains in South Korea remained consistently high during that time.
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  • This study investigated how low-density lipoprotein cholesterol (LDL-C) levels impact recovery after intravenous thrombolysis (IVT) in stroke patients, based on whether they used statins before the stroke.
  • Among the 4711 patients analyzed, those with low to intermediate LDL-C levels did not show improved outcomes compared to those with high LDL-C, indicating that overall LDL-C levels alone are not linked to recovery at 3 months post-treatment.
  • However, for patients who took statins before their stroke, lower LDL-C levels were associated with better recovery outcomes, suggesting that statin use may influence how LDL-C affects recovery after an ischemic stroke.
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Nanostructuring has become a powerful tool for tuning the electronic properties of materials and enhancing transport. As an example of relevance to next-generation battery technologies, nanocrystals have shown promise for realizing fast-ion conduction in solids; however, dissipationless ion transport over extended length scales is hindered by lossy interfaces formed between nanocrystals in a solid. Here we address this challenge by exploiting one-dimensional nanostructures for ion transport.

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  • * The 2020 cases involved two farms, which tested positive for ASF, showing the same genetic markers as the 2019 isolates.
  • * To prevent further outbreaks, stronger biosecurity measures and increased surveillance are recommended, especially in areas where wild boars and domestic pigs interact.
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African swine fever (ASF) is a contagious and deadly viral disease affecting swine of all ages. ASF was first reported in Vietnam in February 2019, and it is now considered endemic in Vietnam. In this study, 122 ASF-positive samples collected from domestic pigs in 28 different provinces of northern, central, and southern Vietnam during outbreaks in 2019-2021 were genetically characterized.

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Background: The demand for aesthetic procedures continues to grow globally, particularly in East Asian countries. The popularity of specific aesthetic procedures varies, however, depending on the particular East Asian geographical region being studied. This study aimed to evaluate the experiences of and attitudes toward aesthetic procedures in five East Asian countries/regions, including China, Japan, South Korea, Hong Kong, and Taiwan.

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Background: No study has thoroughly compared the effectiveness of combined antiplatelet treatments (other than clopidogrel-aspirin) versus clopidogrel-aspirin or aspirin alone for early secondary prevention in acute ischaemic stroke.

Methods: We identified patients with acute, minor, non-cardiogenic ischaemic stroke treated with aspirin alone, clopidogrel-aspirin or other combination treatment. Propensity scores considering the inverse probability of treatment weighting were used to adjust for baseline imbalances.

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  • The study investigated the link between acute and chronic poststroke depression (PSD) and the occurrence of cardio-cerebrovascular events (CVEs) in stroke patients.
  • A cohort of 423 stroke patients was observed over an average of 12 years, with assessments for depression conducted within two weeks and one year post-stroke.
  • Results showed that patients with either acute or chronic PSD experienced a higher incidence of CVEs, indicating that depression negatively impacts long-term cardiovascular health after a stroke.
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Background And Purpose: This study aimed to investigate the value of d-dimer levels in predicting recurrent stroke in patients with embolic stroke of undetermined source. We also evaluated the underlying causes of recurrent stroke according to d-dimer levels.

Methods: A total of 1431 patients with undetermined source were enrolled in this study and divided into quartiles according to their baseline plasma d-dimer levels.

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African swine fever (ASF) is a highly infectious disease of pigs caused by African swine fever virus (ASFV). In order to identify potential genetic variations among ASFV strains circulating in Vietnam, 26 ASFV isolates from organs and blood samples collected from domestic pigs from 23 different provinces of northern, central and southern Vietnam during 2019-2020 ASF outbreaks were genetically characterized. Nucleotide sequences were determined for a portion of the B646L (p72) gene, the complete E183L (p54) gene, the variable region of EP402R (CD2v), the central variable region (CVR) of pB602L, and a tandem repeat sequence (TRS) between the I73R and I329L genes.

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We investigated a multicenter registry to identify estimated event rates according to CHA2DS2-VASc scores in patients with acute ischemic stroke (AIS) and atrial fibrillation (AF). The additional effectiveness of antiplatelets (APs) plus oral anticoagulants (OACs) compared with OACs alone considering the CHA2DS2-VASc scores was also explored. This study retrospectively analyzed a multicenter stroke registry between Jan 2011 and Nov 2017, identifying patients with acute ischemic stroke with AF.

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