Background: Migraine is a neurological disorder characterized by severe, unilateral, pulsating headaches with visual, olfactory, and auditory hypersensitivity, as well as autonomic symptoms. Currently, triptans are the standard treatment, but they often fail to relieve symptoms. Herbal medicines are alternative treatments to overcome these limitations.
View Article and Find Full Text PDFObjective: The commonly used base monomer utilized in resinous commercial dental restorative products is bis-GMA which is derived from bisphenol-A (BPA) - a well-known compound which may disrupt endocrine functions. To address concerns about its leaching into the oral environment and to optimize the quality of dental composites, a BPA-free alternative base monomer, fluorinated urethane dimethacrylate (FUDMA), was designed by modifying a UDMA monomer system.
Methods: Nine groups of composites were prepared by mixing the base monomers and TEGDMA in a ratio of 70/30 wt% to which were added silanized glass particles (mean diameter: 0.
Background: Restless legs syndrome (RLS) is a neurological disorder that causes unpleasant symptoms in the legs when resting, which are relieved by movement. Pharmacotherapy is the standard treatment. However, current treatment provides only symptomatic relief and may result in adverse effects with long-term use.
View Article and Find Full Text PDFGeopung-Chunghyuldan (GCD), which is a mixture of Chunghyuldan (CD), Radix Salviae Miltiorrhizae, Radix Notoginseng, and Borneolum Syntheticum, is used to treat ischemic stroke in traditional Korean medicine. This study aimed to investigate the effects of GCD and CD on ischemic brain damage using in vitro and in vivo stroke models, as well as to elucidate the synergistic effects of GCD against ischemic insult. To study the effect of GCD in an in vitro ischemia model, SH-SY5Y cells were exposed to oxygen-glucose deprivation (OGD).
View Article and Find Full Text PDFObjectives: This paper presents the effect of silane treatment of S-2 Glass fibres on the fracture toughness and water sorption/solubility behaviour of fibre-reinforced flowable dental composites. The effect of epoxy- and methacrylate-based silane coupling agents (SCAs) on the mechanical strength and hydrolytic properties were investigated. The concentration of the selected SCAs on the mechanical and physical properties were investigated.
View Article and Find Full Text PDFBackground: Geopung-Chunghyuldan (GCD) has neuroprotective properties. Radix plays an essential role in GCD's effect. The Radix marker compound is salvianolic acid B; however, its content is not uniform among samples.
View Article and Find Full Text PDFBackground: Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's disease. Currently, no FDA-approved drugs are available for the treatment of VaD. Artemisia annua Linné (AA) is known to have antioxidant properties, but its effects and mechanisms of action on cognitive impairment are still unknown.
View Article and Find Full Text PDFFibre-reinforced biocomposites usage has gained prominence over the past decade. Although higher fracture toughness was observed when fibres were added to biocomposites, material degradation could occur due to filler and fibre content intolerance in the biocomposite matrix. Optimisation of resin-fibre-filler ratios helps in increasing the tribological performance of high load-bearing applications.
View Article and Find Full Text PDFObjectives: Parkinson's disease (PD) is a neurodegenerative disease in which patients are suffering various symptoms. Previous experimental studies suggested that herbal medicine Ukgansan (UGS) could be beneficial for PD. The aim of this pilot clinical trial was to evaluate the efficacy of UGS for improving clinical symptoms in patients with PD.
View Article and Find Full Text PDFIt is well known that bacterial components (pathogen-associated molecular patterns [PAMPs]) induce a proinflammatory response through pattern recognition receptor signaling. What is not known, however, is how the inflammatory response is downregulated. We hypothesize that bacterial products initiate compensatory anti-inflammatory responses by inducing expression of the human glucocorticoid receptor (hGR).
View Article and Find Full Text PDFInt J Environ Res Public Health
September 2022
Polypharmacy is continuously increasing among older adults. The resultant potentially inappropriate medications (PIMs) can be harmful to patient health. Deprescribing refers to stopping or reducing PIMs.
View Article and Find Full Text PDFBackground And Purpose: In Asian countries, herbal medicines have been used to treat diabetic peripheral neuropathy (DPN) as an adjunctive therapy. This review aims to assess the effectiveness and safety of herbal medicines for the treatment of DPN.
Methods: A literature search was conducted on PubMed, Embase, CENTRAL, Scopus, CINAHL, CNKI, DBPIA, and OASIS for randomized controlled trials that evaluated the effects of herbal medicines on DPN.
Objectives: This experimental investigation explored the optimisation of silane treatment of surface-modified S-2 Glass fibres in restorative dental composites for improved mechanical performance. The influence of optimum amount of silane to improve the interfacial adhesion at the fibre-matrix interfaces and its effect on the mechanical properties of the restorative composites were explored.
Methods: S-2 Glass fibres of 5 μm diameter and 250 μm length were surface modified using the acid etching technique.
Alzheimer's disease (AD) is a leading progressive neurodegenerative disease worldwide, and its treatment is a challenging clinical problem. This review was conducted to evaluate the efficacy and safety of herbal medicine for AD treatment. The PubMed, CENTRAL, EMBASE, CNKI, OASIS, KTKP, and CiNii databases were searched until June 2020 for randomized controlled trials (RCTs) on herbal medicine for AD, and a meta-analysis of 57 RCTs was conducted.
View Article and Find Full Text PDFEvid Based Complement Alternat Med
December 2021
Poststroke fatigue (PSF) is reported to occur in 30%-72% of all patients with stroke. PSF not only is a symptom of stroke but has also been reported to adversely affect the prognosis of patients with stroke. However, no treatment has had a significant effect on PSF.
View Article and Find Full Text PDFPost-stroke fatigue (PSF) is among the most common stroke sequelae and affects rehabilitation, resulting in poor recovery. A main influencing factor may be depression, which has been investigated with fatigue in several clinical trials. We aimed to evaluate the characteristics of fatigue in post-stroke patients without depression through a retrospective chart review.
View Article and Find Full Text PDFEvid Based Complement Alternat Med
December 2021
This study aimed to analyze and summarize the existing evidence regarding herbal medicine treatments for amyotrophic lateral sclerosis (ALS). Studies on herbal medicine treatment in patients with ALS were searched within English, Chinese, Japanese, and Korean databases up to July 31, 2021. In the selected studies, we collected the following information: the first author, year of publication, country, language, study methodology, sample size, demographic characteristics of the study participants, disease duration, diagnostic criteria, treatment method, treatment periods, evaluation tools, results, and side effects.
View Article and Find Full Text PDFRationale: Metoclopramide is commonly used to treat nausea and vomiting. However, long-term administration of metoclopramide is associated with various adverse effects, and its therapeutic effects are short-lasting. Hence, traditional East Asian medicine has received increasing attention as a short-term strategy for treating these symptoms.
View Article and Find Full Text PDFPost-stroke fatigue (PSF) is one of the most common emotional and mood disorders in stroke survivors. Several studies have suggested associations between PSF and various factors. However, they describe conflicting results.
View Article and Find Full Text PDFThe Governing Vessel 14 (GV14) (Dazhui) is one of the acupuncture points referred to as "seven acupoints for stroke." Nevertheless, there is a scarcity of research on the effects of acupuncture treatment at GV14. This study investigated the effects of acupuncture at GV14 on cerebral blood flow (CBF), especially that in the basilar artery (BA) and the middle cerebral arteries (MCA).
View Article and Find Full Text PDFRationale: Dopamine replacement is currently the standard treatment for restless leg syndrome (RLS); however, various adverse effects are associated with long-term therapy, and the benefits disappear upon discontinuation. To overcome these limitations, interest in traditional East Asian medicine has increased.
Patient Concerns: A 72-year-old Asian woman originally admitted for an intracerebral hemorrhage presented with complaints of an unpleasant sensation throughout the body that appeared at night.
A potential cause of the variable response to injury and sepsis is the variability of a patient's human glucocorticoid receptor (hGR) profile. To identify hGR variants, blood samples were collected on admission and biweekly thereafter from hospitalized patients who sustained at least a 20% total body surface area burn injury. A hyperactive G1376T single-nucleotide polymorphism (SNP) isoform was identified.
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