Publications by authors named "Kihan Yap"
Studies have indicated the potential importance of the human nasal and respiratory microbiomes in health and disease. However, the roles of these microbiomes in the pathogenesis of influenza and its complications are not fully understood. Therefore, the objective of this systematic review and analysis is to identify the patterns of nasal and respiratory microbiome dysbiosis and to define the unique signature bacteria associated with influenza compared with other respiratory tract infections.
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- Obstructive sleep apnoea (OSA) is suspected to be linked to floppy eyelid syndrome (FES), but previous research has produced inconclusive results regarding this association.
- This study systematically reviewed data from four medical databases and conducted a meta-analysis on observational studies to determine the relationship between OSA and FES, finding that more severe OSA significantly increases the risk of developing FES.
- The analysis concluded that severe OSA correlates with the highest risk of FES, and further longitudinal studies are necessary for a more definitive understanding of this relationship.
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases characterized by fatty accumulation in hepatocytes, ranging from steatosis, non-alcoholic steatohepatitis, to cirrhosis. While histopathological evaluation of liver biopsies plays a central role in the diagnosis of NAFLD, limitations such as the problem of interobserver variability still exist and active research is underway to improve the diagnostic utility of liver biopsies. In this article, we provide a comprehensive overview of the histopathological features of NAFLD, the current grading and staging systems, and discuss the present and future roles of liver biopsies in the diagnosis and prognostication of NAFLD.
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