Publications by authors named "Kieu C D Nguyen"

Background: The current manuscript's aim was to determine the human papillomavirus (HPV) genotype-specific prevalence and distribution among individuals, males, and females, of different ages in the region of Apulia, Italy, highlighting the possible variables involved in the carcinogenicity mechanism. In addition, we proposed two hypothetical models of HPV's molecular dynamics, intending to clarify the impact of prevention and therapeutic strategies, explicitly modeled by recent survey data.

Methods: We presented clinical data from 9647 participants tested for either high-risk (HR) or low-risk (LR) HPV at the affiliated Bari Policlinic University Hospital of Bari from 2011 to 2022.

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Coronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding replicase and structural proteins for the virus.

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It is well established the importance of stem cells (SCs) in tissue growth, regeneration and repair, given their ability to self-renew and differentiate into mature cells. Stem cells are present in all individuals and are potentially active to the end of life. However, less is known about their unique function within the immune system as immune regulators and their important task in viral protection.

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Article Synopsis
  • The text discusses how human papillomavirus (HPV) and another unspecified pathogen are common in sexually transmitted infections and contribute to cervical cancer and infertility risks.
  • It highlights that a significant percentage of sexually active individuals become infected with these pathogens and emphasizes the role of the host's microbiome and immune system in the progression of these infections.
  • The study aims to underscore the importance of maintaining a healthy vaginal microbiome and the interconnected factors that help prevent oncogenic mutations in the vaginal environment.
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Life is based on a highly specific combination of atoms, metabolism, and genetics which eventually reflects the chemistry of the Universe which is composed of hydrogen, oxygen, nitrogen, sulfur, phosphorus, and carbon. The interaction of atomic, metabolic, and genetic cycles results in the organization and de-organization of chemical information of that which we consider as living entities, including cancer cells. In order to approach the problem of the origin of cancer it is therefore reasonable to start from the assumption that the sub-molecular level, the atomic structure, should be the considered starting point on which metabolism, genetics, and external insults eventually emanate.

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Many factors may influence the risk of being infected by SARS-CoV-2, the coronavirus responsible for coronavirus disease 2019 (COVID-19). Exposure to the virus cannot explain the variety of an individual's responses to the virus and the high differences of effect that the virus may cause to some. While a person's preexisting condition and their immune defenses have been confirmed to play a major role in the disease progression, there is still much to learn about hosts' genetic makeup towards COVID-19 susceptibility and risk.

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  • Life is fundamentally composed of atomic interactions, metabolism, and genetics, primarily involving elements like hydrogen, oxygen, and carbon, which together contribute to both normal cells and cancer cells.
  • Understanding cancer's origins requires recognizing that cancer cells share structural and metabolic similarities with basic prokaryotic organisms, despite the persistent mysteries surrounding cancer despite extensive research.
  • New scientific approaches highlight the role of electron behavior in cellular processes and emphasize the impact of magnetic fields on biological systems, suggesting that changes at atomic and metabolic levels in mitochondria could lead to the development of cancer cells.
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  • * A study involving 107 HBV-related HCC patients revealed that most had HBV genotypes B (57.9%) and C (42.1), specifically sub-genotypes B4 and C1.
  • * The study found the double mutation A1762T-G1764A was common in these patients, especially in genotype C, indicating a potential area for further research and monitoring in HBV infections.
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  • The commentary discusses the potential connection between metabolic diseases like type 2 diabetes and bone degeneration.* -
  • It highlights how these diseases may affect the differentiation of mesenchymal stem cells, which are crucial for bone development.* -
  • Specifically, the focus is on the molecular mechanisms that prevent these stem cells from transforming into osteoblasts and osteocytes, important cells for maintaining healthy bones.*
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: Quang Nam province in the Centre of Vietnam has faced an outbreak of dengue hemorrhagic fever (DHF) in 2018. Although DHF is a recurrent disease in this area, no epidemiological and microbiological reports on dengue virus serotypes have been conducted mainly due to lack of facilities for such a kind of advanced surveillance. The aim of this study was to detect different dengue virus serotypes in patients' blood samples.

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The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), still remains a severe threat. At the time of writing this paper, the second infectious wave has caused more than 280,000 deaths all over the world. Italy was one of the first countries involved, with more than 200,000 people reported as infected and 30,000 deaths.

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Background: A novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) emerged in December 2019 in China, spreading worldwide. The aim of the present investigation was to evaluate the immunological response and the clinical subset of peripheral lymphocyte subset alteration in COVID-19 infection.

Methods: the study was conducted on four different clinical groups ( = 4; total = 138).

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Background: Based on recent findings, we speculated the existence of the lung, heart, and kidney axis as the main pathway for the COVID-19 disease progression.

Methods: This paper reports on an observational study conducted by a team of researchers and doctors of the 118-Pre-Hospital and Emergency Department of SG Moscati of Taranto City in Italy. The study was conducted on a totality of 185 participants that were divided into three groups.

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To date, several cases of thrombosis have been confirmed to be related to Sars-CoV-2 infection. Multiple attempts detected the prolonged occurrence of Sars-CoV-2 viral RNA (long COVID) in whole blood suggesting that virus byproducts may remain within cells and tissues well over the disease has finished. Patients may develop severe thrombocytopenia, acute anemia of inflammation and, systemic thrombosis with the fatal course of disease, which is suggestive of further interferences of Sars-CoV-2 on hematopoietic stem cells (HSCs) within the differentiation process towards erythroid and megakaryocytic cells.

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  • The study investigates the use of adipose tissue-derived mesenchymal stem cells (AT-MSCs) combined with collagen substrates to create cartilage grafts for treating cartilage lesions and osteoarthritis.
  • The researchers cultured AT-MSCs on a cleaned collagen scaffold and differentiated them into chondrocytes, evaluating the resulting extracellular matrix for specific cartilage markers.
  • Findings suggest that the dermal collagen enhances the quality and function of chondrocytes, paving the way for improved cartilage grafts and addressing limitations in current clinical treatments.
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  • The COVID-19 pandemic has overwhelmed emergency care systems globally, creating challenges due to high patient volumes, limited information, and scarce medical resources, complicating efforts to understand the disease's transmission and immunity.
  • Most COVID-19 related deaths are linked to atypical pneumonia, severe thromboembolism, and systemic inflammatory responses that can lead to multi-organ failure.
  • The study from SG Moscati Hospital in Italy found that elderly men with preexisting conditions, such as COPD, cancer, and cardiovascular diseases, faced higher mortality rates, prompting a reassessment of the underlying pathophysiology to improve treatment and prevention strategies.
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The current treatment and prevention procedures of oral disorders follow a very targeted approach considering mouth and its structures as a system that is completely independent, than the rest of the body. The main therapeutic approach is to keep the levels of oral bacteria and hygiene in an acceptable range compatible with oral-mouth health, completely separated from systemic microbial homeostasis (eubiosis vs dysbiosis). This can negatively impact the diagnosis of a more complex systemic disease and its progression.

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Background: Oral pathogens may exert the ability to trigger differently the activation of local macrophage immune responses, for instance and induce predominantly pro-inflammatory (M1-like phenotypes) responses, while oral commensal microbiota primarily elicits macrophage functions consistent with the anti-inflammatory (M2-like phenotypes).

Methods: In healthy individuals vs. periodontal disease patients' blood samples, the differentiation process from monocyte to M1 and M2 was conducted using two typical growth factors, the granulocyte/macrophage colony stimulating factor (GM-CSF) and the macrophage colony stimulating factor (M-CSF).

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  • Chronic periodontitis (CP) is a serious global issue linked to bone loss, associated with oral dysbiosis and an imbalance in inflammatory gene responses.
  • This research focused on the role of interleukin 10 (IL-10) gene polymorphisms in patients with CP, analyzing samples from 96 Caucasian individuals from Italy.
  • The findings revealed a connection between IL-10 gene variants and other inflammatory genes, highlighting the need for further research to enhance diagnosis and treatment strategies for periodontal disease.
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