Publications by authors named "Kieron Lucas"
Group A Streptococcus (Strep A) is a human-exclusive bacterial pathogen killing annually more than 500,000 patients, and no current licensed vaccine exists. Strep A bacteria are highly diverse, but all produce an essential, abundant, and conserved surface carbohydrate, the Group A Carbohydrate, which contains a rhamnose polysaccharide (RhaPS) backbone. RhaPS is a validated universal vaccine candidate in a glycoconjugate prepared by chemical conjugation of the native carbohydrate to a carrier protein.
View Article and Find Full Text PDFArticle Synopsis
- * This study investigates the conversion of D-Glc to D-Ara in the trypanosomatid Crithidia fasciculata, finding that both arms of the pentose phosphate pathway are involved, along with the function of a specific enzyme (GFAT).
- * The research suggests a general pathway for producing D-Ara from D-Glc in eukaryotes, highlighting its roles in synthesizing important compounds, including
Biosynthesis of the nucleotide sugar precursor dTDP-L-rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus; GAS), Streptococcus mutans and Mycobacterium tuberculosis. Streptococcal pathogens require dTDP-L-rhamnose for the production of structurally similar rhamnose polysaccharides in their cell wall. Via heterologous expression in S.
View Article and Find Full Text PDF