Publications by authors named "Kieran P H Wynne"
Cancers (Basel)
November 2021
Article Synopsis
- Clear cell renal cell carcinoma (ccRCC) is the most prevalent type of kidney cancer, primarily triggered by mutations affecting oxygen sensing in kidney cells.
- Current lab techniques fall short in replicating the diverse environment of ccRCC tumors, which leads to a need for improved models to study both tumor and supporting stromal cells.
- The study identified a unique extracellular matrix (ECM) composition in ccRCC, mainly consisting of collagen VI, fibronectin, and tenascin C, and developed a nine-component ECM blend that enables the growth of both tumor and stromal cells for better modeling and analysis of cell interactions in a tumor-like setting.
