Publications by authors named "Kieran Latto"
Objectives: The dynamics of monosodium urate (MSU) crystal changes across a range of serum urate concentrations in people with gout are unknown. This study aimed to systematically examine the relationship between serum urate and changes in dual-energy CT (DECT) urate volume in people with gout and stable serum urate concentrations.
Methods: Individual participant data were analysed from three studies of people with gout.
Objective: This study aimed to identify variables that predict gout remission in people with erosive gout receiving urate-lowering therapy.
Methods: We analyzed data from a two-year, double-masked randomized-controlled trial of people with erosive gout, randomized to a serum urate target of <0.20 mmol/L or <0.
Article Synopsis
- DECT and Gout
- : Dual energy computed tomography (DECT) helps visualize monosodium urate crystals in gout, but its volume data is often skewed, complicating statistical analysis in longitudinal studies.
- Methodology
- : The study created simulated datasets and tested five data transformation methods to normalize DECT urate volumes, followed by linear regression analysis to assess changes over one year.
- Findings
- : None of the transformation methods effectively normalized the data; however, significant reductions in DECT urate volumes were observed from baseline to Year 1 across all methods, indicating challenges in accurately analyzing skewed data distributions.
Objective: To determine whether a therapeutic approach of intensive serum urate lowering results in improved bone erosion scores in patients with erosive gout.
Methods: We undertook a 2-year, double-blind randomized controlled trial of 104 participants with erosive gout who were receiving serum urate-lowering therapy orally and who had serum urate levels of ≥0.30 mmoles/liter at baseline.