Hypersegmented neutrophils and oval macrocytes in the setting of B deficiency and pancytopaenia.

Vitamin B deficiency is a recognised pathology in several populations, with a particular prevalence in an older adult population. We present two cases whereby vitamin B deficiency is the causative factor in marked pancytopaenia. Oval macrocytosis and hypersegmented neutrophils were noted on both peripheral blood samples, which are a characteristic finding in macrocytic anaemia due to B deficiency.

The interaction of moxifloxacin and warfarin in three elderly patients.

Moxifloxacin is an oral 8-methoxyquinolone with a broad spectrum of anti-microbial activity. Clinical trials indicate that moxifloxacin is a safe and well-tolerated antibiotic. We describe a potentially serious interaction between moxifloxacin and warfarin in three frail, elderly patients.