Noradrenaline spillover during exercise in active versus resting skeletal muscle in man.

Increases in plasma noradrenaline (NA) concentration occur during moderate to heavy exercise in man. This study was undertaken to examine the spillover of NA from both resting and contracting skeletal muscle during exercise. Six male subjects performed one-legged knee-extension so that all measurements could be made both in the exercising and in the resting leg.

Lipoprotein lipase activity and intramuscular triglyceride stores after long-term high-fat and high-carbohydrate diets in physically trained men.

Men with regular physical training habits voluntarily increased their dietary fat intake from 43 to 54% of energy (E%) for four weeks. This was followed by a low-fat (29 E%), high-carbohydrate diet for another four weeks. During the high-fat diet period, the muscle lipoprotein lipase activity (LPLA) increased from 59 +/- 8 to 106 +/- 12 mU/g (mean +/- SE) (P less than 0.

Intramuscular pressure, EMG and blood flow during low-level prolonged static contraction in man.

Seven men performed one-legged isometric knee-extension at 5% MVC for 1 h. Intramuscular pressure increased with contraction from its resting value of 14 (2-31) mmHg. Some intramuscular pressure recordings stayed at an almost constant level through the 1 h contraction, but most recordings showed large fluctuations from resting values up to 90 mmHg.

Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia?

Blood flow (Q) to quadriceps muscles was measured by thermal dilution in six men during rest and dynamic exercise [20, 38, and 42.5-60 W (peak load)] restricted to quadriceps of one leg in normoxia (N) and hypoxemia (H; 10-11% O2). Without exception Q and quadriceps vascular conductance were higher in H.

Role of hemoglobin and capillarization for oxygen delivery and extraction in muscular exercise.

Through the years the role of the various links in the transport of oxygen in the human body has been discussed extensively, and especially whether one of these links could be singled out as limiting oxygen uptake during exercise. In his thesis work Lars Hermansen dealt with several of these variables related to oxygen transport and uptake. Two of these were the hemoglobin concentration of the blood (Hb) and skeletal muscle capillarization.

Non-response of muscle capillary density and lipoprotein-lipase activity to regular training in diabetic patients.

Ten obese women with normal glucose tolerance, 10 obese patients with sulphonylurea-treated non-insulin-dependent diabetes (NIDD) and 11 patients with insulin-dependent diabetes (IDD; treated for 3-31 yr) took part in a 10-week programme of physical training in 50-min sessions, 2-3 times a week. As a result of training, maximal oxygen uptake increased significantly by about 18, 13 and 8% in the 3 groups, respectively, and citrate synthase in muscle increased significantly by 27-42%. The lipoprotein-lipase activity in muscle tissue (sampled by a needle-biopsy technique from the lateral vastus muscle) did not change.

Further increase in high density lipoprotein in trained males after enhanced training.

Eight well-trained males were studied before, during and after 6 months of a progressively increased amount of endurance training in order to elucidate the effects on the apoproteins and apolipoproteins. Initially high HDL-cholesterol levels were revealed (1.62 +/- 0.

Minor dietary effects of HDL in physically active men.

In a preceding prospective study an increased high-density lipoprotein (HDL)-cholesterol and apolipoprotein (apo) A-I concentration occurred in healthy, non-obese, initially sedentary men, aged 30--44 years, after 3 months of physical training. Dietary history data revealed an increase in the absolute amount of fat-intake. In the present study we investigated whether a changed fat intake would influence the levels of lipoproteins, especially the HDL fraction, in twenty-three regularly conditioning men, aged 30--44 years, with a maximal aerobic capacity of 53.

Increased plasma HDL-cholesterol and apo A-1 in sedentary middle-aged men after physical conditioning.

Previous studies have demonstrated an inverse relationship between plasma high density lipoproteins (HDL) cholesterol and coronary heart disease risk. In the present study we investigated prospectively the effect of a moderate physical conditioning programme on plasma lipids and lipoproteins, especially HDL-cholesterol and apolipoprotein A-I (apo A-I), the major apoprotein of HDL. Healthy, sedentary, middle-aged men were randomly selected and assigned either to a training group (n = 24, age 40 +/- 3.