A contribution to the scientific assessment of degenerative and regenerative processes of peripheral nerve fibers following axonotmesis under the systemic administration of vitamins B1, B6 and B12--light and electron microscopy findings of the saphenous nerve in the rabbit.

The present study investigates the de- and regenerative changes in the saphenous nerve of the rabbit following systemic treatment with a combination of the vitamins B1, B6 and B12 and a control group that was treated with physiological saline solution. Cold lesion of the nerve, which led to an optimal axonotmesis, was used to cause a secondary degeneration. After 4, 10 and 21 days the nerves were removed and investigated by light and electron microscopy.

[Modification of degenerative and regenerative processes in peripheral nerves by treatment with B vitamins].

Degenerative and regenerative changes in the saphenous nerve of the rabbit following systemic treatment with either a combination of the vitamins B1, B6 and B12 or physiological saline solution were investigated. Cold lesion of the nerve (-196 degrees C), which led to an optimal axonotmesis, was used to cause a secondary degeneration. The nerves were removed and investigated by light and electron microscopy after 4, 10 and 21 days.

[Effect of locally applied corticoids on the morphology of peripheral nerves following neurotmesis and microsurgical suture].

The present work deals with the morphology of cut peripheral nerves anastomosed by primary microsurgical suture. The important question was whether the well-known anti-inflammatory, anti-exudative and fibroblast-inhibiting effects of locally applied glucocorticoids can influence the morphology of degenerating and regenerating peripheral nerves. After cutting the saphenous nerve of the rabbit and prior to its microsurgical suture the synthetic crystalline glucocorticoids methylprednisolone, prednisolone and dexamethasone were applied between the distal and proximal nerve stumps (interfascicular surface application).

Sympathetic innervation of the pulmonary artery, ascending aorta, and coronar glomera of the rabbit. A fluorescence microscopic study.

Adrenergic nerve fibres were demonstrated in the connective tissue of the rabbit coronar glomera by means of the formaldehyde-induced fluorescence technique for catecholamines. This type of innervation is similar to the adrenergic nerve supply to the rabbit and cat carotid body. Adrenergic fibres terminate subendothelially and only a few can be traced to type I cells in the glomera coronaria.

Sympathetic innervation of the carotid bifurcation in the rabbit and cat: blood vessels, carotid body and carotid sinus. A fluorescence and electron microscopic study.

Two postganglionic branches of the superior cervical ganglion enter the area of the carotid bifurcation in the rabbit and the cat. The common and external carotid arteries receive a rich adrenergic nerve supply, which can be demonstrated by fluorophores of biogenic amines appearing after formaldehyde treatment. The internal carotid artery is only sparsely innervated; however, it shows a dense sympathetic supply at the site of pressor receptors.