Expectations and fear of diabetes-related long-term complications in people with type 2 diabetes at primary care level.

Aims: The quality report of patients enrolled in the disease management programmes of North Rhine Westphalia 2016 showed prevalence of long-term complications in diabetes type 2: neuropathy 24.2%, nephropathy 12.5%, retinopathy 8.

Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease.

Aim: To investigate a possible role for a recently identified polymorphism in the gene of cytochrome P450 2E1, the presence of which is associated with high activity of the enzyme.

Methods: Two hundred and thirty-nine alcohol consumers, ICD 10.1/.

Relation between body mass index and radiological progression in patients with rheumatoid arthritis.

Objective: To determine if there is an influence of body mass index (BMI) on the radiological progression in early and longer duration rheumatoid arthritis (RA).

Methods: Fifty-four patients with RA were observed in a progressive 2 year followup for radiological progression of joint damage. At the beginning of study, 27 (50%) patients had a duration of complaints less than 6 months, grouped as early RA.

Lack of efficacy of naltrexone in the prevention of alcohol relapse: results from a German multicenter study.

In a placebo-controlled, double-blind German multicenter study (seven sites) the efficacy of naltrexone as an adjunctive treatment in alcoholism to maintain abstinence was assessed for 12 weeks. A total of 171 detoxified patients (97.7% met the DSM-III-R criteria for alcohol dependence) were included.

"Healthometer"--an instrument for self-distributed health screening and prevention in the population.

In the ongoing expansion of medical systems toward prevention and health promotion, primary care is increasingly recognized as a key vehicle and agent. In order to establish a comprehensive health dialogue in the population, there is a need for innovative instruments corresponding to the information and linked media revolution that this shift is a part of. Based upon the experiences of the Department of Preventive Medicine in Malmö, Sweden, a self-mediated, interactive health testing and promotion instrument called "healthometer" has been developed and tested for feasibility.

[Altered composition of gangliosides in the erythrocyte membrane and in the plasma of alcoholic patients].

Gangliosides were isolated from plasma and membranes of erythrocytes of alcoholics. The pattern of gangliosides were compared with the data of healthy donors. Up to 7 fractions of gangliosides could been detected after extraction, purification by column chromatography and fractionation by TLC.

[Abnormal gangliosides in the plasma of alcoholics].

Gangliosides were isolated from plasma of alcoholics. The pattern of gangliosides was compared with that of healthy humans. Up to seven fractions of gangliosides could be detected.

[Abnormal erythrocyte membrane gangliosides in alcoholism].

The pattern of gangliosides in membranes of erythrocytes was examined in healthy donors and in alcoholic subjects. Seven different gangliosides could be detected. In healthy donors the following pattern was found: GM3 = 17.

Abnormality of gangliosides in erythrocyte membranes of schizophrenic patients.

The pattern of gangliosides in membranes of erythrocytes was examined in healthy donors, in acute schizophrenics without neuroleptic treatment and in alcohol-dependent patients. 7 different gangliosides could be detected. Healthy donors were characterized by the following ganglioside pattern: GX = 5.

[Changes in the gangliosides of erythrocyte membranes of schizophrenic patients].

The pattern of gangliosides in membranes of erythrocytes was examined in healthy donors, in acute schizophrenics without neuroleptic treatment and in alcohol-dependent patients. 7 different gangliosides could be detected after extraction, purification by column chromatography and fractionation by TLC. Healthy donors were characterized by the following pattern of gangliosides: GX = 5.

Heart rate variability in chronic alcoholics: a follow-up study.

Heart rate variability (HRV) was studied in 11 chronic alcoholic subjects, 1-30 days after the beginning of abstinence and again 5, 12 and 24 weeks later. Two patients could be re-examined after 19 and 22 months, respectively. In the follow-up study, the total patient group showed a statistically significant increase in HRV with prolonged abstinence of at least 6 months.

[Autonomic alcoholic polyneuropathy].

Measurement of heart rate variability was performed in a group of 106 healthy volunteers and 31 alcoholics. The mean momentary arrhythmia of normal individuals shows an exponential decrease with growing age. In 5 of 31 alcoholics a cardiac autonomic neuropathy was found with this parameter.

Heart rate variability of chronic alcoholics in withdrawal and abstinence.

Measurement of heart rate variability was performed in 106 healthy volunteers and 31 alcoholics. The mean momentary arrhythmia (MMA) of normal individuals showed an exponential decrease with increasing age. Cardiac autonomic neuropathy was found in 5 of 31 alcoholics.