Estimated potential of human drivers and automatic braking to prevent frontal crashes based on headlight visibility.

Objective: In 2021; half of crash fatalities occurred at night when some road users, like pedestrians, are particularly vulnerable. Automatic emergency braking (AEB) systems can avoid or mitigate collisions by automatically applying the brakes, but their performance may be hindered in low lighting. The purpose of this study was to estimate the proportion of real-world crashes where headlights could provide enough visibility for the driver or AEB system to detect and avoid the collision.

Pedestrian automatic emergency braking responses to a stationary or crossing adult mannequin during the day and night.

Objective: Automatic emergency braking systems with pedestrian detection (PAEB) are effective at preventing pedestrian crashes, but the safety benefits are not observed at night. This study used the Insurance Institute for Highway Safety (IIHS) PAEB test data to characterize PAEB responses in different lighting conditions and for different rated systems.

Methods: Data from 6,919 IIHS PAEB tests were retrieved from IIHS databases.

Industrial Genotoxicology Group (IGG): 36th Annual Meeting Report.

The proceedings of the 36th annual meeting of the Industrial Genotoxicology Group (IGG) are shared here. The meeting held at Lhasa Limited, Leeds, UK on 28th November 2023, focussed two aspects; New Approach Methodologies (NAM's), including those for the assessment of non-standard modalities such as gas-vapour assessments and nanomaterials, and addressing the regulatory challenges associated with understanding the genotoxic and carcinogenic potential of N-nitrosamines and N-nitrosamine impurities. New approach methodologies, such as error-corrected sequencing and enhanced Ames tests that may help address these challenges were also discussed.

Neuropathological evidence for neurosarcoidosis is more widespread than imaging suggests.

We present a single case of a 47 year old male with a relapsing progressive neurological disease characterised by an infiltrative inflammation of the brain and leptomeninges. Investigations revealed the presence of systemic sarcoidosis which was confirmed histologically following a mediastinal lymph node biopsy. The imaging appearances of the brain and spinal canal lesions were compatible with neurological involvement by the same disease.

Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment.

ToxTracker is a mammalian cell reporter assay that predicts the genotoxic properties of compounds with high accuracy. By evaluating induction of various reporter genes that play a key role in relevant cellular pathways, it provides insight into chemical mode-of-action (MoA), thereby supporting discrimination of direct-acting genotoxicants and cytotoxic chemicals. A comprehensive interlaboratory validation trial was conducted, in which the principles outlined in OECD Guidance Document 34 were followed, with the primary objectives of establishing transferability and reproducibility of the assay and confirming the ability of ToxTracker to correctly classify genotoxic and non-genotoxic compounds.

Are front crash prevention systems less effective at preventing rear-end crashes where trucks and motorcycles are struck?

Objective: Automatic emergency braking (AEB) and forward collision warning (FCW) are effective at preventing rear-end crashes, but they may perform better in some rear-end crash scenarios than others. The goal of this study was to estimate the effects of front crash prevention systems equipped to passenger vehicles in crashes where another passenger vehicle, a medium/heavy truck, or a motorcycle is struck and compare effectiveness by struck vehicle type.

Methods: More than 160,000 two-vehicle rear-end crashes were identified where a passenger vehicle with or without FCW and AEB was the striking vehicle and another passenger vehicle, medium/heavy truck, or motorcycle was the struck vehicle.

Neurosarcoidosis.

Sarcoidosis affects the nervous system in 5% of cases. 60% of cases involve the cranial and peripheral nerves, the remainder the central nervous system, in which a leptomeningitis, a pachymeningitis and a vasculitis may arise. Stroke and cerebral haemorrhage may occur, and certain infections in the brain are more likely with sarcoidosis.

Gastrointestinal dysmotility complicating Behçet's syndrome: description of a newly recognised clinical phenotype.

Objectives: Gastrointestinal dysmotility may arise in a variety of auto-immune and auto-inflammatory diseases and hitherto has not been described in Behçet's syndrome (BS).

Methods: We present data on a cohort of seven patients under our care who presented with symptoms of and investigations compatible with an immune associated disorder of gastrointestinal motility, or enteric neuropathy.

Results: We describe the clinical features and investigation results.

Cerebral infarction in Behçet's syndrome caused by obliterative focal arteritis.

We present a case in which cerebral infarction was seen and Behcet's syndrome was diagnosed. Following investigation and monitoring, we identified that the cause was a progressive obliterative focal arteritis of the middle cerebral artery. Such an entity has not previously been reported, although similar cases are described which explain the pathophysiology of the disorder.

Neurological involvement by Behçet's syndrome: clinical features, diagnosis, treatment and outcome.

Neurological involvement in Behçet's syndrome arises predominately through an inflammatory meningoencephalitis characterised by perivenular inflammation due to activation of Th-17 immunological pathways. The brainstem is involved in 50% of cases, the diencephalon and other areas of the brain in 30%, and the spinal cord in 10%. Movement disorders and epilepsy may occur.

Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.

Error-corrected Next Generation Sequencing (ecNGS) is rapidly emerging as a valuable, highly sensitive and accurate method for detecting and characterizing mutations in any cell type, tissue or organism from which DNA can be isolated. Recent mutagenicity and carcinogenicity studies have used ecNGS to quantify drug-/chemical-induced mutations and mutational spectra associated with cancer risk. ecNGS has potential applications in genotoxicity assessment as a new readout for traditional models, for mutagenesis studies in 3D organotypic cultures, and for detecting off-target effects of gene editing tools.

Survival analysis of germination data in response to temperature for species and other temperate pasture legumes.

Cool temperatures can limit productivity of temperate grazing systems as poor pasture growth rates in winter create feed shortages for livestock. Ornithopus spp. (serradella) are broadly adapted annual pasture legumes that produce high-quality forage in soil types considered marginal for other temperate legume species.

Understanding potentially avoidable hospitalisations in a rural Australian setting from the perspectives of patients and health professionals: a qualitative study and logic model.

Background: Potentially avoidable hospitalisations (PAHs) are proxy measures of effective primary care at a population level. PAHs are higher in rural and disadvantaged areas. This qualitative study sought a deeper understanding of PAHs for chronic health conditions in a rural context from the perspectives of patients and health professionals, and aimed to develop a logic model for rural health services to identify intervention targets.

How can front crash prevention systems address more police-reported crashes in the United States?

Government and consumer-information organizations can motivate automakers to address additional crash types through front crash prevention (FCP) testing programs. This study examined the current state of crashes potentially relevant to current and future FCP systems to provide a roadmap for the next crash types that vehicle testing programs in the United States should evaluate. Crash records from 2016 to 2020 were extracted from the Crash Report Sampling System (CRSS) and the Fatality Analysis Reporting System (FARS).

Characteristics of automatic emergency braking responses in passenger vehicles evaluated in the IIHS front crash prevention program.

Researchers can estimate the potential safety benefits of front crash prevention (FCP) systems by simulating system performance in rear-end crash scenarios reported to police or captured during naturalistic driving. Data to support assumptions about FCP systems in production vehicles, particularly automatic emergency braking (AEB), are limited. This study used detailed information from the Insurance Institute for Highway Safety's (IIHS's) FCP evaluation to characterize interventions in vehicles that performed well (superior-rated vehicles) and those that did not perform as well (basic/advanced-rated vehicles) when approaching a stationary surrogate vehicle on a test track at 20 and 40 km/h, and estimated performance in similar conditions at higher speeds.

Increasing seat belt use in the United States by promoting and requiring more effective seat belt reminder systems.

Objective: Federal Motor Vehicle Safety Standard (FMVSS) 208 requires every passenger vehicle to provide an auditory signal lasting 4 to 8 seconds and a visual display lasting 60 seconds when the driver is unbelted at ignition. This requirement does not increase seat belt use. This paper summarizes the latest research on using vehicle technology to increase seat belt use and existing safety standards worldwide to support the strengthening of FMVSS 208.

Management of neurosarcoidosis.

This is a brief and purposefully practical approach to the therapeutic and rehabilitative management of patients affected by neurological complications of systemic sarcoidosis. The review notes the drugs used and their monitoring, and their role in the series of clinical subgroups identified to form the condition. Treatment guidelines for individual clinical subtypes of the disorder are provided, and the importance of rehabilitative measures and lifestyle changes are emphasised.

Can the speed limit be used as a surrogate for the striking vehicle's travel speed or delta-V in police-reported rear-end crashes?

A recent study by Kidd (2022) recommended that organizations evaluating front crash prevention (FCP) systems like automatic emergency braking and forward collision warning increase speed differentials in existing test scenarios from 25 mph to 45 mph to make the tests more representative of police-reported rear-end crashes. Kidd used the posted speed limit as a proxy for the striking vehicle's travel speed prior to the crash. The current study used velocity data from event data recorders (EDRs) in rear-end crashes to evaluate this assumption.

Improving the safety relevance of automatic emergency braking testing programs: An examination of common characteristics of police-reported rear-end crashes in the United States.

Objective: Forward collision warning and automatic emergency braking (AEB) systems help prevent rear-end crashes where a vehicle strikes the rear of another. However, the benefits may be limited if the systems are stymied by common crash circumstances or only target scenarios evaluated in vehicle testing programs. This study examined the prevalence of characteristics that may limit AEB system performance in police-reported rear-end crashes and the relevance of scenarios used to evaluate these systems.

Short- and Long-Term Complications of Free Anterolateral Thigh Flap Reconstructions: A Single-Centre Experience of 92 Consecutive Cases.

Background: The anterolateral thigh (ALT) flap has been amongst the most versatile components of the reconstructive surgeon's armamentarium. The authors utilise these flaps for a variety of reconstructive procedures including lower limb reconstruction; postsarcoma excision; and open fractures. Few studies have discussed the extent of recipient site morbidity and subsequent revisional procedures.

Critical phosphorus requirements of Trifolium species: The importance of root morphology and root acclimation in response to phosphorus stress.

Differences in root morphology and acclimation to low-phosphorus (P) soil were examined among eight legume species from the Trifolium Section Tricocephalum to understand how these root attributes determine P acquisition. Ornithopus sativus was included as a highly P-efficient benchmark species. Plants were grown as microswards in pots with five rates of P supplied in a topsoil layer to mimic uneven P distribution within a field soil profile.