Evaluation of different spelling layouts for SSVEP based BCIs.

Brain-computer interface (BCI) systems enable humans to communicate with their environment by directly using brain signals. This way, body movement is not explicitly required for communication making this technology especially useful for people with limited mobility. In this study, the system performance and well-being of 38 subjects are investigated using two different layouts of graphical user interfaces (GUI) presented on a computer screen.

[Patient-oriented management of aggression and violence in psychiatry. Description of a training program and first results].

Violence, aggression, and patient assaults result in a considerable number of job-related accidents in psychiatry. We describe a patient-oriented training program for managing aggression and violence in psychiatry. Ratings by 335 training participants indicate high to very high acceptance.

Pleomorphic adenoma of the parotid gland: a 13-year experience of consequent management by lateral or total parotidectomy.

Optimal surgical management of parotid pleomorphic adenoma is important because of a considerable risk of tumour recurrence and complications. Our series of primary surgery cases with standardised parotidectomy technique in a university hospital were evaluated. Medical records of 295 patients treated from 1987 to 1999 were reviewed, and 171 patients answered a questionnaire about long-term sequelae.

Inhibition of ciramadol glucuronidation by benzodiazepines.

Studies on the inhibition of ciramadol glucuronidation by benzodiazepines were performed in vitro and in vivo. Ciramadol glucuronidation was slower (Vmax, 1.56 vs.

Gas chromatographic determination of guanabenz in biological fluids by electron-capture detection.

A sensitive gas chromatographic method for the determination of guanabenz[(2,6-dichlorobenzylidene)amino]guanidine in urine and plasma was developed. The method depends upon the acid hydrolysis of guanabenz to 2,6-dichlorobenzaldehyde, which has strong electron capturing properties and is volatile enough to be eluted from a gas chromatographic column. Concentrations as low as 0.

Pharmacokinetic disposition of guanabenz in the rhesus monkey.

The pharmacokinetics of guanabenz (E-2,6-dichlorobenzylidene aminoguanidine acetate, Wy-8678) in rhesus monkeys given 14C-labeled and unlabeled drug were investigated. The radioactive dose was well absorbed after intragastric (ig) administration of 1 mg of the labeled drug per kg, as indicated by tissue and urinary recovery of the label. Excretion into urine accounted for 57 +/- 3 (SE)% of the radioactive ig dose.

Relationship of guanabenz concentrations in brain and plasma to antihypertensive effect in the spontaneously hypertensive rat.

The antihypertensive agent guanabenz (E-2,6-dichlorobenzylidene aminoguanidine acetate. Wy-8678) was administered i.v.