Publications by authors named "Kiara Homil"
Rhinoviruses (RVs) can cause severe wheezing illnesses in young children and patients with asthma. Vaccine development has been hampered by the multitude of RV types with little information about cross-neutralization. We previously showed that neutralizing antibody (nAb) responses to RV-C are detected twofold to threefold more often than those to RV-A throughout childhood.
View Article and Find Full Text PDFBackground: Genome-wide association studies have identified several risk alleles for early childhood asthma, particularly in the 17q21 locus and in the cadherin-related family member 3 (CDHR3) gene. Contribution of these alleles to the risk of acute respiratory tract infections (ARI) in early childhood is unclear.
Methods: We analyzed data from the STEPS birth-cohort study of unselected children and the VINKU and VINKU2 studies on children with severe wheezing illness.
Background: Acute rhinovirus-induced wheezing is common in young children and may respond to systemic corticosteroid. There are no trials on the efficacy of inhaled beta -agonist in this clinical scenario.
Objective: To study post hoc the short-term (up to 2 months) efficacy of inhaled beta -agonist with and without oral corticosteroid in the first acute rhinovirus-induced severe wheezing episode in young hospitalized children.
Article Synopsis
- Rhinovirus C (RV-C) can cause a range of respiratory issues, from asymptomatic cases to serious wheezing, and its relationship with age and individual factors was studied using data from the COAST birth cohort.
- The analysis revealed that RV-A and RV-C infections were similar in infants, but RV-C was significantly less common in older children during illnesses.
- By age 16, seropositivity to RV-C was much higher than for RV-A, indicating a need for better understanding of RV types and immune responses to inform vaccine development.