Ankyrin repeat-rich membrane spanning/Kidins220 protein interacts with mammalian Septin 5.

Neurotrophin receptors utilize specific adaptor proteins to activate signaling pathways involved in various neuronal functions, such as neurite outgrowth and cytoskeletal remodeling. The Ankyrin-Repeat Rich Membrane Spanning (ARMS)/kinase D-interacting substrate-220 kDa (Kidins220) serves as a unique downstream adaptor protein of Trk receptor tyrosine kinases. To gain insight into the role of ARMS/Kidins220, a yeast two-hybrid screen of a rat dorsal root ganglion library was performed using the C-terminal region of ARMS/Kidins220 as bait.

Human mesenchymal stem cell-derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production, in a model of spinal cord injury.

Human bone marrow-derived mesenchymal stem cells (hMSCs) are considered a desirable cell source for autologous cell transplantation therapy to treat nervous system injury due to their ability to differentiate into specific cell types and render the tissue microenvironment more favorable for tissue repair by secreting various growth factors. To potentiate their possible trophic effect, hMSCs were induced without genetic modification to adopt characteristics of Schwann cells (SCs), which provide trophic support for regenerating axons. The induced hMSCs (shMSCs) adopted a SC-like morphology and expressed SC-specific proteins including the p75 neurotrophin receptor, which correlated with cell-cycle exit.

Transplantation of mesenchymal stem cells enhances axonal outgrowth and cell survival in an organotypic spinal cord slice culture.

Mesenchymal stem cells (MSCs) have demonstrated a measurable therapeutic effect following transplantation into animal models of spinal cord injury. However, the mechanism(s) by which transplanted cells promote nerve regeneration and/or functional recovery remains indeterminate. Several studies have suggested that MSCs promote tissue repair via secretion of trophic factors, but delineating the effect of such factors is difficult due to the complexity of the in vivo systems.

Relationship between the curve of Spee and dentofacial morphology evaluated with a 3-dimensional reconstruction method in Korean adults.

Introduction: The purposes of this study were to examine the curve of Spee of the maxillary and mandibular arches by using a 3-dimensional reconstruction method and to determine the relationship between the curve of Spee and dentofacial morphology with multiple regression analysis.

Methods: Lateral cephalograms and dental models were evaluated from 18 Korean men and 31 Korean women. The depth of the curve of Spee was measured on the virtual dental models with computer software.

The three-dimensional relationship on a virtual model between the maxillary anterior teeth and incisive papilla.

Statement Of Problem: The incisive papilla as an anatomical landmark has historically been used to determine anterior incisal tooth position for complete denture prostheses. There are numerous data regarding its position, but 3-dimensional orthographic measurements are scarce.

Purpose: The purpose of this study was to evaluate the orthographic anteroposterior distance between the posterior border of the incisive papilla and a reference point or vector.

Quantitative evaluation of the accuracy of micro-computed tomography in tooth measurement.

Micro-computed tomography (MCT) is a noninvasive technique for visualizing morphological characteristics of teeth in a detailed and accurate manner, without causing any tooth destruction. A large amount of information can be obtained from such scans. The slices can be recreated in any plane, and the data can be represented as either two-dimensional (2D) or three-dimensional (3D) images.