Publications by authors named "Ki-Seo Yoo"
The role of Arhgef4, also known as adenomatous polyposis coli (APC)-stimulated guanine nucleotide exchange factor 1 (Asef1), has been identified in colorectal cancers. Interestingly, Arhgef4 is more highly expressed in brain regions than intestinal regions, suggesting a role in neurons. In our previous study, we reported that Arhgef4 negatively regulates the level of PSD-95 in excitatory post-synaptic regions by binding with Staufen1.
View Article and Find Full Text PDFGuanine nucleotide exchange factors (GEFs) play multiple functional roles in neurons. In a previous study, we reported that (Rho guanine nucleotide exchange factor 4) functioned as a negative regulator of the excitatory synaptic function by sequestering postsynaptic density protein 95 (PSD-95). However, the role of in behavior has not been examined.
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- * Researchers used a defective form of KIF5A, a motor protein, to show that its absence lowers PSD-95 levels in dendrites, indicating KIF5's role in transporting PSD-95.
- * The study also found a dose-dependent relationship between the Staufen protein and the association of PSD-95 with KIF5A, suggesting Staufen may help regulate this transport process.
Article Synopsis
- Guanine nucleotide exchange factors (GEFs) like Asef1 are crucial for various cell functions, particularly in the brain, but the specific role of Asef1 in neurons is not well understood.
- Asef1 was found to inhibit the proper localization of the synaptic protein PSD-95, which is important for excitatory synapses, leading to impaired synaptic transmission in hippocampal neurons.
- Neuronal activity triggers the release of Asef1 from its partner Staufen through a PI3K-dependent process, highlighting its role as a negative regulator in synaptic functions.