Publications by authors named "Ki-Hun Kim"
Background: Acquired diaphragmatic hernia (DH) is a rare and potentially fatal complication after living donor hepatectomy (LDH). This study aimed to assess the incidence and clinical outcomes of DH after LDH.
Methods: Four thousand fourteen living donors who underwent LDH at Asan Medical Center, Seoul, between September 2013 and August 2023 were retrospectively reviewed.
Predicting futile outcomes following deceased donor liver transplantation in non-Hcc patients with MELD-Na score above 30: a retrospective international multicenter cohort study.
Int J Surg
February 2025
Background: In the current "sickest first" allocation policy for limited deceased liver grafts, identifying patients "too sick to transplant" before transplantation is crucial to optimize outcomes. This study aimed to predict futile outcomes following deceased donor liver transplantation (DDLT) in patients with Model for End-Stage Liver Disease-Sodium (MELD-Na) scores ≥30.
Methods: This international multicenter study was conducted as part of the International Society of Liver Surgeons.
Objective: This study aimed to compare morbidity of living donors and recipients after pure laparoscopic donor right hepatectomy (PLDRH) and open donor right hepatectomy (ODRH).
Background: Donor and recipient morbidity have not been sufficiently reported in large-scale comparisons of PLDRH and ODRH.
Methods: This retrospective study reviewed 3348 donors who underwent PLDRH (n=329) and ODRH (n=3019) and their corresponding recipients (n=3348) between January 2014 and August 2023.
Prognostic Efficacy of the Albumin-Bilirubin Score and Treatment Outcomes in Hepatocellular Carcinoma: A Large-Scale, Multi-Center Real-World Database Study.
Liver Cancer
December 2024
Introduction: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality globally, with treatment outcomes closely tied to liver function. This study evaluates the prognostic utility of the albumin-bilirubin (ALBI) score compared to the traditional Child-Pugh (CP) grading, leveraging real-world evidence from a large-scale, multi-center database.
Methods: The Liver Cancer IN Korea (LINK) research network, a multi-center initiative, retrospectively collected electronic health records from three academic hospitals in South Korea, encompassing HCC patients diagnosed between 2015 and 2020.
Introduction: Little is known about age and clinical intervention after implantable loop recorder (ILR) insertion. This study investigated the association between age and clinical intervention after ILR implantation.
Methods And Results: Data were obtained from a multicenter registry of ILR in Korea (2017-2020, n = 795).
Introduction: Pulmonary vein isolation (PVI) by cryoballoon ablation (CBA) is considered an effective primary strategy for early persistent atrial fibrillation (AF). However, data regarding CBA for long-standing persistent AF (PeAF) are limited. We evaluated the efficacy and safety of CBA for long-standing PeAF compared to PeAF.
View Article and Find Full Text PDFBackground & Aims: Surgery is the only curative therapeutic option for resectable extrahepatic cholangiocarcinoma, but recurrence is common, and prognosis is poor. There is an unmet clinical need for improved decision-making regarding adjuvant chemotherapy (ACT). Herein, we evaluated the usefulness of monitoring longitudinal circulating tumor DNA (ctDNA) for molecular residual disease (MRD) in patients from the STAMP trial, which compares the efficacy of adjuvant capecitabine (CAP) vs.
View Article and Find Full Text PDFBackground & Aims: Liver transplantation for hepatocellular carcinoma (HCC) in metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly being diagnosed and predicted to rise further. We compared outcomes of transplantation for MASLD-related HCC versus other etiologies (OE).
Methods: Databases were searched to identify studies comparing outcomes after transplantation MASLD-related HCC with OE-related HCC.
Pure laparoscopic living-donor right hepatectomy (PLDRH) has emerged as a significant advancement in liver transplantation, offering reduced donor morbidity and improved recovery times. However, PLDRH is still performed in only a limited number of centers. This retrospective study reports on the outcomes of 215 living donors who underwent PLDRH at Asan Medical Center in Seoul, Korea between November 2014 and December 2021.
View Article and Find Full Text PDFPurpose: To evaluate the potential of incorporating respiratory muscle strength, specifically maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP), along with traditional sarcopenia screening measures such as hand grip strength (HGS) and skeletal muscle mass index (SMI), to identify sarcopenia in older men.
Materials And Methods: A retrospective analysis was conducted involving male patients aged 65 years and older who underwent measurements of respiratory muscle strength, HGS, and muscle mass at a general hospital in Korea from July 2016 to May 2022. Statistical analysis utilized independent t-tests and receiver operating characteristic (ROC) curves to assess the sensitivity and specificity of MIP, MEP, HGS, and SMI in sarcopenia screening.
Article Synopsis
- This study compares adult living donor liver transplantation (LDLT) and deceased donor liver transplantation (DDLT) outcomes in patients with acute liver failure over a 14-year period.
- The findings show no significant differences in in-hospital mortality, long-term survival, or graft survival rates between the two methods, although LDLT patients had shorter intensive care unit stays.
- The research concludes that LDLT is a viable alternative for patients awaiting liver transplants, particularly when deceased donor organs are not accessible.
Article Synopsis
- Researchers conducted a trial comparing edoxaban monotherapy with dual antithrombotic therapy in patients with atrial fibrillation and stable coronary artery disease to assess risks of stroke and other serious outcomes.
- The study involved 1,040 patients, with results showing fewer primary-outcome events in those on edoxaban alone (6.8% vs. 16.2% for dual therapy), indicating it may be safer.
- Although the incidence of major bleeding was higher in the dual therapy group (14.2% vs. 4.7%), the major ischemic events were similar for both treatment groups.
Primary treatments for solitary hepatocellular carcinoma ≤ 3 cm: A systematic review and network meta-analysis.
Ann Hepatobiliary Pancreat Surg
November 2024
Article Synopsis
- This study examines the best treatment options for small solitary hepatocellular carcinoma (HCC) tumors that are 3 cm or less, focusing on the effectiveness of various interventions.
- A network meta-analysis assessed the long-term outcomes of 30 studies including surgical resection (SR), radiofrequency ablation (RFA), microwave ablation (MWA), and transarterial chemoembolization (TACE), with SR showing the best survival rates.
- The results indicate that surgical resection is the preferred first-line treatment, particularly in patients with good liver function, while more research is needed on MWA and TACE due to limited data.
Introduction: The impact of early recurrence of atrial tachyarrhythmia (ERAT) within the 90-day blanking period on long-term outcomes in atrial fibrillation (AF) patients undergoing cryoballoon ablation (CBA) is controversial. This study aimed to assess the relationship between ERAT and late recurrence of atrial tachyarrhythmia (LRAT) post-CBA.
Methods: Utilizing data from a multicenter registry in Korea (May 2018 to June 2022), we analyzed the presence and timing of ERAT (<30, 30-60, and 60-90 days) and its association with LRAT risk after CBA.
Background: Although surgical resection is the only curative treatment for biliary tract cancer, in some cases, the disease is diagnosed as unresectable at initial presentation. There are few reports of conversion surgery after the initial treatment for unresectable locally advanced biliary tract cancer. This study aimed to evaluate the efficacy and safety of conversion surgery in patients with initially unresectable locally advanced biliary tract cancer.
View Article and Find Full Text PDFIntroduction: This study examined associations between the graft-to-recipient weight ratio (GRWR) for adult-to-adult living donor liver transplantation (LDLT) and hepatocellular carcinoma (HCC) outcomes.
Materials And Methods: Data from patients in the Korean Organ Transplantation Registry who underwent LDLT for HCC from 2014 to 2021 were retrospectively reviewed. Patients were categorized using the cutoff GRWR for HCC recurrence determined by an adjusted cubic spline (GRWR <0.
Association between body mass index and results of cryoballoon ablation in Korean patients with atrial fibrillation: an analysis from the Korean Heart Rhythm Society Cryoablation registry.
Europace
May 2024
Article Synopsis
- Cryoablation is a safe and effective treatment for atrial fibrillation (AF), but its outcomes may vary by body mass index (BMI) in patients, especially in Asians.
- In a study involving 2,648 patients, underweight individuals had a higher recurrence rate of AF after treatment compared to those with a normal BMI, along with a greater risk of complications like transient phrenic nerve palsy.
- These findings suggest that underweight patients require special attention during and after cryoablation due to increased risks of both AF recurrence and procedural complications.
Article Synopsis
- Living donor liver transplantation (LDLT) has become a preferred option over deceased donor transplantation, especially in countries like South Korea with low organ donation rates.
- The Asan Medical Center (AMC) has conducted over 6000 LDLT procedures, developing advanced surgical techniques and achieving high patient survival rates.
- This large study reveals that tailored surgical approaches and multidisciplinary care significantly enhance the long-term success and safety of LDLT for both adults and children.
Background: Pregnancy-associated spontaneous coronary artery dissection (SCAD) and reversible cerebral vasoconstriction syndrome (RCVS) are rare conditions that may occur during pregnancy and the postpartum period. The coexistence of both diseases may pose a risk to patients, potentially resulting in a variety of complications and clinical manifestations. This is considered the first case of a patient who successfully recovered from a critical condition in the postpartum period, with contemporaneous SCAD and RCVS.
View Article and Find Full Text PDFArticle Synopsis
- A study in South Korea examined the safety and effectiveness of liver transplants from living donors who lost at least 10% of their body weight to reduce liver fat (steatosis) before donating their right lobe.
- Out of 1,040 donors, 150 were in the weight loss group and showed significant improvements in body weight and BMI, with similar postoperative outcomes and complication rates compared to a control group.
- The findings suggest that weight loss can effectively enhance liver health in donors, leading to comparable surgical success in both recipients of improved grafts and standard grafts.
Regorafenib has anti-tumor activity in patients with unresectable hepatocellular carcinoma (uHCC) with potential immunomodulatory effects, suggesting that its combination with immune checkpoint inhibitor may have clinically meaningful benefits in patients with uHCC. The multicenter, single-arm, phase 2 RENOBATE trial tested regorafenib-nivolumab as front-line treatment for uHCC. Forty-two patients received nivolumab 480 mg every 4 weeks and regorafenib 80 mg daily (3-weeks-on/1-week-off schedule).
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- The COVID-19 pandemic significantly affected global liver transplantation (LT) and living donor programs, prompting the study to examine how these programs adapted and succeeded during this period.
- The research focused on 1201 living donor liver transplants performed at Asan Medical Center between 2020 and 2022, highlighting key patient demographics and medical outcomes.
- Despite higher than usual in-hospital mortality at 2.2%, and various challenges, the program maintained high standards of care and successful outcomes thanks to established infection control protocols and tailored surgical strategies.
Article Synopsis
- Hepatic artery thrombosis (HAT) occurs in 2.5%-8% of living-donor liver transplant patients, leading to potential graft loss, and the study focuses on understanding risk factors and reconstruction techniques for grafts with multiple hepatic arteries.
- The research analyzed 1601 patients who received right lobe grafts, finding that pretransplant hepatectomy, female donor, smaller graft-to-recipient weight ratio, and extra-anatomical reconstruction increased HAT risk, while having two hepatic arteries did not.
- Survival rates were similar between patients with one and two hepatic arteries, suggesting that reconstructing both arteries when possible might be a beneficial approach in transplant surgeries.
Article Synopsis
- * After one year of daily finasteride treatment, patients were categorized based on their treatment response and further divided into two groups for another year of either daily or EOM treatment.
- * Results showed that both treatment regimens had similar maintenance effects on hair density, but the daily group had better hormone level outcomes and slightly higher hair density than the EOM group.
Background And Aim: Domino liver transplantation (DLT) utilizes otherwise discarded livers as donor grafts for another recipients. It is unclear whether DLT has less favorable outcomes compared to deceased donor liver transplantation (DDLT). We aimed to assess the outcomes of DLT compared to DDLT.
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