Ecohydrological investigation of cloud seeding effect on vegetation activity in the Boryeong Dam Basin, South Korea.

Cloud seeding is well known to address water shortage problems caused by droughts by adding more precipitation and consequent runoff. Unlike previous studies, this study investigates another positive effect of cloud seeding on the activation of vegetation by integrating numerical cloud seeding simulations and processed-based modeling of various ecohydrological components. As the carbon cycle is closely related to the hydrological processes in ecosystems, we adopt the RHESSys ecohydrological modeling to synthetically simulate runoff and soil moisture along with primary productivity and vegetation respiration.

A novel highly potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, INU-101.

11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a cortisol regenerating enzyme that amplifies tissue glucocorticoid levels, especially in the liver and adipose tissue. Knockout mice or a selective inhibitor of 11β-HSD1 improves metabolic syndrome parameters in preclinical models and human clinical trials. Here, we evaluated the therapeutic potential of INU-101, a potent and selective oral inhibitor of 11β-HSD1.