Publications by authors named "Ki-Bum Won"
Objectives: This study evaluated the association between serum albumin levels and coronary artery calcification (CAC) progression in asymptomatic adults without hypoalbuminaemia at baseline.
Design: Observational cohort study.
Setting: Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) which is a retrospective, single ethnicity, multicentre and observational registry were analysed.
Data on hyperuricemia-related changes in coronary atherosclerosis are limited, especially in sex difference. This study evaluated the association between hyperuricemia and coronary artery calcification (CAC) progression in asymptomatic Korean men and women. We analysed the data of 12,316 asymptomatic adults (51.
View Article and Find Full Text PDFBackground: Both insulin resistance and hyperglycemia are important risk factors for atherosclerosis. While the characteristics of atherosclerosis are obviously different according to established diabetes, little has been known regarding the risk of coronary artery calcification (CAC) progression related to the biomarkers of atherogenic index of plasma (AIP), triglyceride glucose (TyG) index, and hemoglobin A1C (HbA1C) in conditions with and without diabetes.
Methods: We analyzed 12,326 asymptomatic Korean adults (mean age 51.
This study evaluated the association of atherogenic index of plasma (AIP) with platelet reactivity and clinical outcomes according to acute myocardial infarction (AMI). The composite of 3-year adverse outcomes of all-cause death, myocardial infarction, and cerebrovascular accident was evaluated in 10,735 patients after successful percutaneous coronary intervention with drug-eluting stents. AIP was defined as the base 10 logarithm of the ratio of triglyceride to high-density lipoprotein cholesterol concentration.
View Article and Find Full Text PDFMetabolically healthy obesity (MHO) is known to have a close association with subclinical coronary atherosclerosis. Despite recent data on the benefit of intensive systolic blood pressure (SBP) control in diverse clinical conditions, little is known regarding the association of normal SBP maintenance (SBP) with coronary artery calcification (CAC) progression in MHO. This study included 2724 asymptomatic adults (48.
View Article and Find Full Text PDFCoronary stent underexpansion is associated with restenosis and stent thrombosis. In clinical studies of atherosclerosis, high wall shear stress (WSS) has been associated with activation of prothrombotic pathways, upregulation of matrix metalloproteinases, and future myocardial infarction. We hypothesized that stent underexpansion is predictive of high WSS.
View Article and Find Full Text PDFBackground Clopidogrel monotherapy was more effective in reducing the risk of adverse clinical events than aspirin monotherapy in patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stent (DES), according to the HOST-EXAM (Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis-Extended Antiplatelet Monotherapy) trial. However, it remains unknown whether these effects differ based on sex. Methods and Results This was a prespecified secondary analysis of HOST-EXAM in South Korea.
View Article and Find Full Text PDFBackground: Patients with coronary artery disease and impaired renal function are at higher risk for both bleeding and ischemic adverse events after percutaneous coronary intervention (PCI).
Objectives: This study assessed the efficacy and safety of a prasugrel-based de-escalation strategy in patients with impaired renal function.
Methods: We conducted a post hoc analysis of the HOST-REDUCE-POLYTECH-ACS study.
Background: The baseline coronary plaque burden is the most important factor for rapid plaque progression (RPP) in the coronary artery. However, data on the independent predictors of RPP in the absence of a baseline coronary plaque burden are limited. Thus, this study aimed to investigate the predictors for RPP in patients without coronary plaques on baseline coronary computed tomography angiography (CCTA) images.
View Article and Find Full Text PDFBackground: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited.
Objectives: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA).
Methods: A total of 830 subjects (age 61 ± 10 years, 51.
Background: This study evaluated the association of body mass index (BMI) with adverse clinical outcomes during chronic maintenance antiplatelet monotherapy after percutaneous coronary intervention (PCI) with drug-eluting stents (DES).
Methods and results: Overall, 5,112 patients were stratified (in kg/m) into underweight (BMI ≤18.4), normal weight (18.
Aims: Coronary artery calcium score (CACS) is widely used for cardiovascular risk stratification in asymptomatic population. We assessed the association of new blood pressure (BP) classification using the 2017 American College of Cardiology/American Heart Association guidelines with coronary artery calcification (CAC) progression according to age in asymptomatic adults.
Methods And Results: Overall, 10 839 asymptomatic Korean adults (23.
Background: The optimal duration of dual-antiplatelet therapy (DAPT) after implantation of a drug-eluting stent (DES), especially recently developed polymer-free DESs, is unknown. This study examined the efficacy and safety of 3- versus 6-month DAPT in patients implanted with Coroflex ISAR polymer-free DESs.
Methods: Between May 2015 and August 2020, 488 patients who underwent Coroflex ISAR stent implantation were enrolled in the study and randomly assigned to the 3-month (n=244) or 6-month (n=244) DAPT group.
Background: Atherosclerosis-related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBP ) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease.
Hypothesis: Normal SBP is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease.
Article Synopsis
- This study examines the effects of reducing prasugrel dosage in patients recovering from acute coronary syndrome (ACS) to improve safety and reduce bleeding risks.
- In the analysis of the HOST-REDUCE-POLYTECH-ACS trial, the lower dose (5 mg daily) showed significant benefits in patients with non-ST-segment elevation ACS (NSTE-ACS), decreasing the risk of adverse events compared to the standard dose (10 mg daily).
- However, in patients with ST-elevation myocardial infarction (STEMI), the de-escalated dosage did not result in any significant changes in adverse clinical outcomes, indicating that the benefits of dose reduction may not extend to this more severe condition
Background: Optimal antiplatelet monotherapy during the chronic maintenance period in patients who undergo coronary stenting is unknown. We aimed to compare head to head the efficacy and safety of aspirin and clopidogrel monotherapy in this population.
Methods: We did an investigator-initiated, prospective, randomised, open-label, multicentre trial at 37 study sites in South Korea.
Background And Aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma atherogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA).
Methods: A total of 1488 adults (60.
Article Synopsis
- * Results showed that patients in non-tertiary hospitals were older and had more health issues, but mortality rates (in-hospital death and all-cause death) did not significantly differ between the two hospital types.
- * The findings suggest that the quality of care and outcomes for CIED implantation in Korea are comparable between tertiary and non-tertiary hospitals, even with different patient demographics.
Article Synopsis
- * Among 2560 participants, those with lower Hb levels (group I) had a lower prevalence of carotid plaque compared to the higher Hb groups, with group II showing a particularly reduced risk of plaque formation.
- * The findings suggest that higher serum Hb levels can be a risk factor for carotid plaque beyond the influences of metabolic syndrome, indicating potential implications for cardiovascular health monitoring in otherwise healthy adults.
Background: This study aimed to present the development process and characteristics of the Korean Registry of Acute Myocardial Infarction for Regional Cardiocerebrovascular Centers (KRAMI-RCC).
Methods: We developed KRAMI-RCC, a web-based registry for patients with AMI. Patients from 14 RCCs were registered for more than three years from July 2016.
Patients with coronary artery disease (CAD) are more likely to experience depression and anxiety, which, in turn, are risk factors for CAD. The Beck depression inventory (BDI) and Beck anxiety inventory (BAI) were applied for mood evaluation during hospitalization and again 3 months after discharge in 118 patients with CAD, and cardiopulmonary exercise tests were conducted in the outpatient department. Of the patients diagnosed with CAD, 40 (33.
View Article and Find Full Text PDFThis study aimed to evaluate the association between the atherogenic index of plasma (AIP), which has been suggested as a novel marker for atherosclerosis, and coronary artery calcification (CAC) progression according to the baseline coronary artery calcium score (CACS). We included 12,326 asymptomatic Korean adults who underwent at least two CAC evaluations from December 2012 to August 2016. Participants were stratified into four groups according to AIP quartiles, which were determined by the log of (triglyceride/high-density lipoprotein cholesterol).
View Article and Find Full Text PDFBackground: The impact of serum uric acid (SUA) on atherosclerosis has been suspected to be epiphenomenal owing to its close relationship with metabolic abnormalities. The aim of the present study was to evaluate the association between SUA levels and arterial stiffness in the absence of established cardiovascular (CV) disorders.
Methods: The relationship between SUA levels and brachial-ankle pulse wave velocity (baPWV) was examined in 353 asymptomatic adults (57 ± 8 years, 11.