Publications by authors named "Ki Ho Park"

Purpose: To report the 2-year effective and safety profile of integrated phacoemulsification with intraocular lens implantation (PEI), goniosynechialysis (GSL) and 120° goniotomy (GT) in advanced primary angle-closure glaucoma (PACG) and cataracts.

Design: Multicentre prospective study.

Methods: 201 eyes of 196 patients who received combined PEI+GSL+ GT were assessed at baseline and re-evaluated at days 1, 7, and at 1, 3, 6, 12 and 24 months postsurgery.

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Purpose: To evaluate the two-year outcomes of combined surgical peripheral iridectomy (SPI), goniosynechialysis (GSL), and goniotomy (GT) for advanced primary angle-closure glaucoma (PACG) without cataract.

Design: Multicenter prospective study.

Methods: The study included patients who received a combined SPI + GSL + GT for advanced PACG without cataract, all completed a 24-month follow-up.

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Oxidative stress is the key cause of the etiopathogenesis of several diseases associated with constipation. This study examined whether the green pine cone can improve the symptoms of constipation based on the antioxidant activities. The changes in the key parameters for the antioxidant activity and laxative effects were examined in the loperamide (Lop)-induced constipation of Sprague-Dawley (SD) rats after being treated with the methanol extracts of green pine cone (MPC, unripe fruits of ).

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Myopia is rapidly escalating globally, especially in East and Southeast Asia, where its prevalence among younger populations reaches alarming levels of 80-90 %. This surge contributes to a myopia epidemic linked to several ocular complications, including glaucoma. As myopic individuals age, the risk of developing glaucoma increases, and an additional concern arises from the growing frequency of refractive surgeries among younger individuals, making precise optic nerve assessments critical before surgery.

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Previously, we reported that 3--alkyl difluoroquercetins (di-F-Q) potentiates the antimicrobial activity of aztreonam (ATM) against metallo-β-lactamase (MBL)-producing through simultaneous inhibition of MBLs and efflux pumps. However, the ATM-potentiating activity of the 3--alkyl di-F-Q was observed only at high and potentially toxic concentrations (32 mg/L). As both MBLs and efflux pumps reside in the periplasm of Gram-negative bacteria, their inhibitors should accumulate in the periplasmic space.

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  • MG53 is known for its role in tissue repair and reducing inflammation, but its potential impact on type 2 diabetes is debated.
  • This study investigates whether MG53 affects insulin signaling in various tissues by examining its binding to the insulin receptor and its effects on insulin-stimulated signaling in cells and mice.
  • The results suggest that while MG53 can bind to the insulin receptor, its interaction is weak and not physiologically relevant, challenging the idea that increasing MG53 could be a new treatment for type 2 diabetes.
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  • Body odor can indicate various diseases, but this study specifically aimed to identify odor biomarkers linked to chemical-induced liver damage in rats.
  • Researchers treated Sprague Dawley rats with different doses of 1,2,3-trichloropropane (TCP) and tracked changes in urine odors using gas chromatography-mass spectrometry (GC-MS).
  • They discovered significant increases in several odors, particularly acrolein, which correlated with liver toxicity indicators and expressions of related metabolic enzymes, suggesting acrolein could serve as a new diagnostic marker for liver damage from TCP exposure.
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Natural products with high antioxidant activity are considered as innovative prevention strategies to effectively prevent age-related macular degeneration (AMD) in the early stage because the generation of reactive oxygen species (ROS) leading to the development of drusen is reported as an important cause of this disease. To investigate the prevention effects of the methanol extracts of L. (MEE) on AMD, its effects on the antioxidant activity, inflammatory response, apoptosis pathway, neovascularization, and retinal tissue degeneration were analyzed in N-retinylidene-N-retinylethanolamine (A2E)-landed spontaneously arising retinal pigment epithelia (ARPE)-19 cells and BALB/c mice after exposure to blue light (BL).

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Background: Restenosis poses a significant challenge for individuals afflicted with peripheral artery diseases, often leading to considerable morbidity and necessitating repeated interventions. The primary culprit behind the pathogenesis of restenosis is intimal hyperplasia (IH), in which the hyperproliferative and migratory vascular smooth muscle cell (VSMC) accumulate excessively in the tunica intima. 6-Phosphogluconate dehydrogenase (6PGD), sometimes referred to as PGD, is one of the critical enzymes in pentose phosphate pathway (PPP).

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Article Synopsis
  • * Gene expression analysis revealed 1237 genes were upregulated and 1292 genes downregulated in C3 KO mice, with specific genes related to constipation identified.
  • * The research highlights a novel gene candidate that may help understand and potentially treat constipation linked to C3 deficiencies, particularly through the modulation of mucin-related gene expression.
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Importance: Although optic disc hemorrhage (DH) is widely recognized as a glaucoma risk factor, its clinical relevance in relation to proximity has not been investigated.

Objective: To determine the association of the proximal location of DH with glaucoma progression.

Design, Setting, And Participants: In this longitudinal observational cohort study, 146 eyes of 146 patients at Seoul National University Hospital who had had 1 or more DH with at least 5 years of follow-up and had at least 5 reliable visual field examinations were included.

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Purpose: To compare the efficacy and safety of omidenepag isopropyl (OMDI) 0.002% with latanoprost 0.005% once daily in Asian subjects with open-angle glaucoma (OAG)/ocular hypertension (OHT).

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Purpose: To investigate whether a difference exists in intereye glaucoma severity and progression in patients with asymmetric axial length.

Design: Long-term observational study.

Participants: Patients older than 20 years with a diagnosis of glaucoma at Seoul National University Hospital, Seoul, Korea, between 2010 and 2020.

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In recent years, there has been increasing interest in exploring the potential therapeutic advantages of extracts (CME) for nonalcoholic steatohepatitis (NASH). In this study, we investigated the therapeutic effects of CME on NASH using a mice model. High-performance liquid chromatography (HPLC) was employed to identify cucurbitacin E and cucurbitacin E-2-O-glucoside from the CME.

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Despite the improved outcomes in patients with hematological malignancies, infections caused by multidrug-resistant organisms (MDROs) pose a new threat to these patients. We retrospectively reviewed the patients with hematological cancer and bacterial bloodstream infections (BSIs) at a tertiary hospital between 2003 and 2022 to assess the impact of MDROs on outcomes. Among 328 BSIs, 81 (24.

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Background: Human induced pluripotent stem cells (hiPSCs) and their differentiated cell types have a great potential for tissue repair and regeneration. While the primary focus of using hiPSCs has historically been to regenerate damaged tissue, emerging studies have shown a more potent effect of hiPSC-derived paracrine factors on tissue regeneration. However, the precise contents of the transplanted hiPSC-derived cell secretome are ambiguous.

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Article Synopsis
  • - The study aimed to understand how the shape and size of β-zone parapapillary atrophy (PPA) in glaucoma patients can predict disease progression using Optical Coherence Tomography (OCT) analysis over a mean follow-up of nearly 10 years.
  • - Researchers analyzed 210 patients with primary open-angle glaucoma and found that larger radial and angular extents of β-zone PPA were linked to faster progression of glaucoma, highlighting the importance of PPA characteristics.
  • - Among different shapes of β-zone PPA, the Solar-eclipse type 2 had the highest progression rate, indicating that both PPA morphology and size are crucial for predicting how glaucoma might worsen in patients.
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Purpose: Topical prostaglandin analogues are commonly used to treat patients with glaucoma, but may cause periocular and periorbital complications known as prostaglandin-associated periorbitopathy syndrome (PAPS).

Methods: A literature review was conducted on PAPS. Given the lack of consensus on grading PAPS, glaucoma specialists from Asia convened to evaluate current PAPS grading systems and propose additional considerations in grading PAPS.

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This study investigated intraocular pressure (IOP) in Dutch belted rabbits using two different tonometers, rebound tonometry (TonoVet Plus; TVP) and a Tonopen (Tono-Pen AVIA Vet; TPA). Post-pubescent male Dutch belted rabbits aged 36 weeks (n = 10 animals) were used in the study. IOP measurements were conducted every 2 weeks for 22 weeks using TVP and TPA on both eyes of each rabbit.

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Prcis: The combination of surgical peripheral iridectomy, goniosynechialysis, and goniotomy is a safe and effective surgical approach for advanced primary angle closure glaucoma without cataract.

Purpose: To evaluate the efficacy and safety of surgical peripheral iridectomy (SPI), goniosynechialysis (GSL), and goniotomy (GT) in advanced primary angle closure glaucoma (PACG) eyes without cataract.

Patients And Methods: A prospective multicenter observational study was performed for patients who underwent combined SPI, GSL, and GT for advanced PACG without cataract.

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Article Synopsis
  • The study examines the effectiveness of a combined eye surgery (phacoemulsification, goniosynechialysis, and goniotomy) for treating primary angle closure glaucoma in patients with cataracts, noting that success is not influenced by the severity of peripheral anterior synechiae.
  • It involved 304 eyes from 283 patients over around 12.5 months, showing a significant reduction in intraocular pressure (IOP) post-surgery across all severity groups, with no notable differences in success rates.
  • Although more severe peripheral anterior synechiae (270°≤PAS<360°) experienced increased instances of complications like hyphema, the overall results indicated that the combined procedure is effective regardless of PAS extent
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Purpose: To provide an updated analysis of the long-term outcomes of patients with acute primary angle closure (APAC) and to investigate the risk factors for visual field (VF) loss progression.

Study Design: Retrospective, clinical cohort study METHODS: One hundred and forty-six APAC patients with a minimum of 1-year follow-up were included. The presenting features and the treatment utilized were recorded.

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The discovery of safe and efficient inhibitors against efflux pumps as well as metallo-β-lactamases (MBL) is one of the main challenges in the development of multidrug-resistant (MDR) reversal agents which can be utilized in the treatment of carbapenem-resistant Gram-negative bacteria. In this study, we have identified that introduction of an ethylene-linked sterically demanding group at the 3-OH position of the previously reported MDR reversal agent di-F-Q endows the resulting compounds with hereto unknown multitarget inhibitory activity against both efflux pumps and broad-spectrum β-lactamases including difficult-to-inhibit MBLs. A molecular docking study of the multitarget inhibitors against efflux pump, as well as various classes of β-lactamases, revealed that the 3--alkyl substituents occupy the novel binding sites in efflux pumps as well as carbapenemases.

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Article Synopsis
  • MRSA infections are tough to treat due to their ability to form protective biofilms and resist antibiotics.
  • Researchers tested the impact of low antibiotic concentrations (sub-MICs) on MRSA biofilm formation, finding that many isolates increased biofilm growth when exposed to antibiotics like nafcillin, vancomycin, ciprofloxacin, and rifampin.
  • A majority of MRSA strains tested, particularly the ST5 and ST72 types, exhibited stronger biofilm production at sub-MIC levels, indicating that certain strains and antibiotic classes substantially influence biofilm induction.
  • Understanding these dynamics can help improve treatment strategies for MRSA infections by considering the roles of antibiotic exposure and specific bacterial strains.
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