Publications by authors named "Khyathi Mantripragada"
Leptomeningeal disease (LMD) is a rare yet serious complication of advanced malignancy, often seen in breast cancer and associated with a poor prognosis. This case report highlights the rapid progression and diagnostic challenges encountered in a woman in her 40s with advanced breast cancer who presented with severe headaches, absence seizures, and diplopia. The patient's complex past history included invasive ductal carcinoma, prior brain metastasis, and recent craniotomy, which added significant challenges to diagnosis and management.
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- Mitochondrial cytopathies, particularly from MT-TL1 and MT-ND5 mutations, can lead to mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), marked by multi-organ dysfunction, with a novel MT-ND5 variant being only the second reported case linked to MELAS.
- A middle-aged man presented with severe neurological symptoms, including confusion, speech difficulties, and behavioral changes, alongside a history of refractory seizures and renal disease; imaging revealed significant brain abnormalities, and muscle biopsy identified a novel mutation in the MT-ND5 gene.
- MELAS typically features seizures, stroke-like episodes, and other neurological issues, with kidney transplants in these patients generally offering