Unripe Fresh Fruit Extract Protects against Methylglyoxal-Mediated Aging in Human Dermal Skin Fibroblasts.

The glycolytic metabolite methylglyoxal (MGO) initiates the formation of advanced glycation end products and oxidative stress, leading to cellular senescence and skin aging. This study focuses on the anti-aging properties of unripe L. (UCP) fresh fruit extract on MGO-induced human dermal fibroblast senescence.

Screening of potential tropical fruits in protecting endothelial dysfunction .

Background: High consumption of antioxidant-rich fruits and vegetables reduces the endothelial damage involved in cardiovascular disease pathogenesis.

Objective: To evaluate the phytochemical content, antioxidant and scavenging activities (FRAP, ORAC, OH, HOCl, HO, and O ), endothelial HO-cytoprotective effect, nitric oxide (NO) release activation potential, and endothelial wound healing properties of 10 tropical fruits, comprising pineapple, sugar apple, papaya fruit, longan, mangosteen, lychee, langsat, mango, rambutan, and guava.

Design: Experimental study.

Unripe Protects Methylglyoxal-Invoked Endothelial Cell Inflammation and Apoptosis via the Suppression of Oxidative Stress and Akt/MAPK/NF-κB Signals.

Methylglyoxal (MGO), a highly reactive dicarbonyl compound, causes endothelial oxidative stress and vascular complications in diabetes. Excessive MGO-induced ROS production triggers eNOS uncoupling, inflammatory responses, and cell death signaling cascades. Our previous study reported that unripe (UCP) had antioxidant activities that prevented HO-induced endothelial cell death.

Potential Use of Amla ( L.) Fruit Extract to Protect Skin Keratinocytes from Inflammation and Apoptosis after UVB Irradiation.

Ultraviolet B (UVB) exposure is the primary risk factor for the deadliest type of skin cancer-melanoma. Incorporating natural antioxidants in skin protection products is currently a favored research theme. For this study, we selected L.

Antioxidant Properties of Unripe Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress.

It has been proven that high consumption of fruit and vegetable lowers the risks of cardiovascular and other oxidative stress-related diseases. Here we evaluated the effects of a tropical fruit, unripe (UCP), on endothelial protection against oxidative damage induced by HO. The antioxidant properties of UCP were investigated using the assays of FRAP and ORAC and specific ROS scavenging activities (HO, O , OH, HOCl).