Publications by authors named "Khusraw Jamil"
Article Synopsis
- Pseudomonas aeruginosa is a harmful bacteria that affects people with cystic fibrosis by causing lung problems, while natural killer (NK) cells are part of the immune system that can kill infected or cancerous cells.
- Research shows that NK cells can also kill extracellular P. aeruginosa by using specific effector molecules in a process that requires direct contact with the bacteria.
- The study found that while some proteins were not essential for killing, the combined action of certain granzymes and reactive oxygen species (ROS) was crucial for damaging the bacteria's membrane and effectively eliminating it.
is a major cause of life-threatening mycosis in immunocompetent individuals and responsible for the ongoing epidemic outbreak of cryptococcosis in the Pacific Northwest of North America. This deadly fungus is known to evade important host immune responses, including dendritic cell (DC) maturation and concomitant T cell immunity, via immune evasion mechanisms that remain unclear. Here, we demonstrate that primary human DCs phagocytose but the maturation of phagosomes to phagolysosomes was blocked as a result of sustained filamentous actin (F-actin) that entrapped and concealed the phagosomes from recognition.
View Article and Find Full Text PDFCryptococcus is the most important cause of fungal meningitis in immunocompromised individuals. Host defense against Cryptococcus involves direct killing by NK cells. That NK cells from HIV-infected patients fail to polarize perforin to the microbial synapse and kill C.
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