Publications by authors named "Khushboo Javaid"
Ethnopharmacological Relevance: Rheum webbianum Royle (RW) holds significant ethnopharmacological importance owing to its 5000-year history of cultivation for medicinal and culinary purposes. Demonstrating therapeutic advantages in traditional and contemporary medical practices, RW exhibits key pharmacological effects including anticancer activity, gastrointestinal control, anti-inflammatory properties, and suppression of fibrosis. Despite its recognized vast bioactivities in ethnopharmacology, its efficacy against the colorectal cancer (CRC) remains incompletely understood.
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- The MTHFR gene regulates folate metabolism, and its polymorphisms C677T and A1298C are linked to reduced MTHFR enzyme activity.
- A case-control study focused on the Kashmiri population found that the 677CT genotype is significantly more common in Chronic Myeloid Leukemia (CML) patients compared to healthy controls, indicating a higher risk for developing CML.
- Conversely, the A1298C variant seems to provide a protective effect against CML, while the combination of certain haplotypes also correlates with an increased risk of the disease.