Publications by authors named "Khuri S"

Pancreatic malignant tumors are diverse and characterized by aggressive nature with high mortality rates. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic malignant tumors and accounts for approximately 90% of pancreatic malignancies. A subtype of PDAC, diffuse type PDAC (DTP), is a very rare and underreported tumor, known for its aggressive traits.

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  • * Managing nesidioblastosis includes both medical and surgical options, but effective treatments are not well understood, and the situation is even more complicated for pregnant patients due to limited information available.
  • * A case study of a 22-year-old pregnant woman experiencing severe hypoglycemia highlights the challenges in diagnosing and treating this condition, emphasizing the need for more research to improve clinical practices.
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Pancreatoduodenectomy (PD) is a very complex and highly challenging operation for surgeons worldwide. It is the surgical procedure of choice for the management of benign and malignant diseases of the periampullary region. Although mortality rate following this complicated surgery has fallen to 1-3%, morbidity rate following PD remains high, with almost 30-40% of patients developing at least one complication.

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Emphysematous pancreatitis (EP), a severe form of necrotizing infection of the pancreas, is an extremely rare medical emergency with high rates of mortality. It is characterized by intraparenchymal pancreatic or peri-pancreatic air due to either monomicrobial or polymicrobial infection with gas-forming bacteria or due to entero-pancreatic fistula. EP is classified according to timing from disease onset when air bubble signs were detected on computed tomography (CT) scan, as early onset (within 2 weeks from disease onset) or late (more than 2 weeks from disease onset).

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Lymphangioma is a rare, benign tumor of the lymphatic system. It is believed to be a congenital malformation, when part of the lymphatic channels fail to connect to the main lymphatic system. Lymphangioma is a tumor of the pediatric age, with 50% of patients presenting at birth.

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Gastrocolic (GC) fistula, a rare gastrointestinal pathological condition, is defined as an abnormal connection between the stomach and the colon. Mostly, it involves the greater curvature of the stomach and the transverse part of the colon. Its precise incidence rate is unknown and largely differs between western and eastern nations.

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  • * Lymphoid neoplasms are the most frequently found splenic tumors, while primary angiosarcoma, which makes up 7.4% of malignant splenic tumors, is an aggressive type known for poor prognosis and less than a year of survival post-diagnosis.
  • * The article aims to review existing literature on primary splenic angiosarcoma to enhance the knowledge of healthcare providers regarding its demographic features, symptoms, imaging results, and treatment options, ultimately aiming to improve early diagnosis and patient outcomes.
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Cholelithiasis (gallstones) is a very common medical problem worldwide, with 5-30% of patients demonstrating a combined condition of cholelithiasis and choledocholithiasis (common bile duct stones (CBDS)). CBDS are usually classified as primary or secondary stones. Primary CBDS are defined as stones detected 2 years or more following cholecystectomy, while secondary stones, the most common type, usually migrate from the gallbladder to the bile ducts.

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Anomalies of the pancreas organ, especially congenital anomalies, are very uncommon, and can involve the pancreatic ductal as well as the pancreatic extra-ductal systems. While these anomalies usually present as an incidental radiological finding during adulthood, sometimes, they can present as recurrent upper abdominal pain as a presentation of recurrent episodes of acute idiopathic pancreatitis. Thus, these anomalies should be regarded in the differential diagnosis list, as a cause, for recurrent idiopathic pancreatitis, especially in the adult age group of patients.

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Retroperitoneal tumors (RPTs) are very rare tumors that arise in the large space of the retroperitoneum. About two-third of these tumors are malignant, of which soft tissue sarcoma (STS) is the most common and comprises almost one-third of malignant RPTs. Twenty to thirty percent of RPTs are benign.

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Soft tissue sarcomas (STSs) are rare tumors that represent almost 1% of adult malignant tumors. The annual incidence rate for such tumors is 2 - 5/100,000 population. The most common type of STS in adults is liposarcoma, which represents 15-20% of adult STSs.

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  • Malignant tumors of the gallbladder are uncommon, with adenocarcinoma as the most prevalent type, while carcinosarcoma is an extremely rare variant that accounts for less than 1% of gallbladder cancers.
  • Carcinosarcoma can occur in various organs, but it is typically found in the uterus, and its diagnosis is challenging due to its unique combination of epithelial and mesenchymal components.
  • As there have been fewer than 100 cases documented in English literature, this article aims to enhance awareness among healthcare professionals to improve diagnosis, treatment, and survival rates for patients with this rare condition.
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  • - The COVID-19 pandemic, caused by the SARS-CoV-2 virus, led to a severe increase in illness and death rates in 2020, with respiratory symptoms being the most common among patients, but gastrointestinal symptoms also became important.
  • - Research has shown that SARS-CoV-2 can affect the pancreas, suggesting that COVID-19 may lead to conditions like acute pancreatitis in some patients.
  • - A reported case involves a patient who, after being diagnosed with COVID-19, developed acute pancreatitis and later a pancreatic pseudocyst, which was treated successfully; this case represents only the second documented instance of such complications linked to COVID-19.
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Introduction: Of the complications following pancreatoduodenectomy (PD), postpancreatoduodenectomy hemorrhage (PPH) is the least common, but severe forms can be life-threatening without urgent treatment. While early PPH is mostly related to surgical hemostasis, late PPH is more likely due to complex physiopathological pathways secondary to different etiologies. The understanding of such etiologies could therefore be of great interest to help guide the treatment of severe, potentially life-threatening, late PPH cases.

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Hydatid disease is a zoonotic disease caused mainly by the cestode (tapeworm) , also known as hydatidosis. It is endemic mainly in areas where dog/horse breeding and sheep farming are common, such as Australia, New Zealand and the Mediterranean region. A rare, yet serious, complication of hydatid cyst of the liver is rupture, which could be spontaneous due to increased intra-cystic pressure or following a traumatic injury of the abdomen.

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Background: One of the critical steps during pancreatoduodenectomy (PD) procedure lies in identifying the complicated vascular anatomy of the resected area. The blood supply usually stems from branches of the celiac and the superior mesenteric arteries. However, only in 55-79% of surgeries, the anatomy of the blood vessels encountered by the surgeon is considered normal, while in the remaining cases, there are vascular variations that make these surgeries even more challenging.

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Background: Early cholecystectomy for acute cholecystitis has proved to reduce hospital length of stay but with no benefit in morbidity when compared to delayed surgery. However, in the literature, early timing refers to cholecystectomy performed up to 96 h of admission or up to 1 week of the onset of symptoms. Considering the natural history of acute cholecystitis, the analysis based on such a range of early timings may have missed a potential advantage that could be hypothesized with an early timing of cholecystectomy limited to the initial phase of the disease.

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  • Immunoglobulin G4 sclerosing cholangitis (IgG4-SC) is a rare type of cholangitis linked to IgG4-related disease, marked by bile duct thickening and high serum IgG4 levels.
  • Distinguishing IgG4-SC from other conditions like primary sclerosing cholangitis and extra-hepatic cholangiocarcinoma is crucial due to their differing treatments and outcomes.
  • Early and accurate diagnosis is vital, as IgG4-SC responds well to steroid treatment, while delays can result in severe complications and require more invasive procedures.
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Introduction: Band migration is a late complication of Laparoscopic Adjustable Gastric Banding insertion, although rare it could be life threatening presenting as peritonitis secondary to gastro-intestinal tract injuries. A case of an unexpected extension of severe gastro-intestinal tract injuries secondary to intra-gastric migration and distal band dislocation is reported.

Presentation Of Case: A 53 years old male, with a history of laparoscopic gastric banding 15 years before and known erosion of the band into the gastric lumen was admitted for abdominal pain and raised serum amylase.

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Background: Early laparoscopic cholecystectomy has been adopted as the treatment of choice for acute cholecystitis due to a shorter hospital length of stay and no increased morbidity when compared to delayed cholecystectomy. However, randomised studies and meta-analysis report a wide array of timings of early cholecystectomy, most of them set at 72 h following admission. Setting early cholecystectomy at 72 h or even later may influence analysis due to a shift towards a more balanced comparison.

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