Unraveling the effect of spermidine on biochemical, anatomical and yield attributes in chickpea under chloride dominated salinity.

This study investigates the effect of foliar application of spermidine (Spd) on salt-stressed chickpea genotypes under natural environmental conditions. Four chickpea genotypes were treated with chloride-dominated salinity levels of 4.0 and 8.

Mammaglobin negative secretory carcinoma of salivary gland--a diagnostically challenging case report.

Secretory carcinoma, impacting the salivary gland, embodies a low-intermediate grade malignancy characterized by the propensity for local dissemination. The fourth edition of the 2017 head and neck World Health Organization's repertoire has recently integrated SC of the salivary gland into its classification scheme. We aim to delve into a case involving a 35-year-old female presenting with swelling on the left side of her face, persisting for the past 12 years, and exhibiting a negative mammaglobin status.

Congenital Cheek Salivary Fistula Associated with an Aberrant Parotid Duct System: Embryological Considerations and Surgical Repair.

Congenital cheek salivary fistula is a rare developmental anomaly with an abnormal connection between the parotid gland and the skin. An eight-year-old child presented with an opening on the right cheek, with intermittent saliva leakage aggravated during food intake and recurrent infections. Imaging studies had confirmed the diagnosis.

Isolation, phytochemical characterization, and inhibitory potential of essential oil from Citrus hystrix DC. fruit peels against foodborne and phytopathogenic microbes.

Plant-based essential oils are currently targeted sources because of their non-toxic, bioactivity, and safety of non-targeted organisms. Various volatile components such as terpenoids, phenolics, and alkaloids make it compatible with broad-spectrum applications. In the current study, essential oil from Citrus hystrix DC.

Attention Deficit Hyperactivity Disorder in Obesity and Hypertension: A Study Among Young Adults in Delhi NCR, India.

Objective: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder increasingly recognized as an adult health concern. It is linked to behavioral disinhibitions that are studied to be associated with mental and physical health adversities, including obesity and hypertension, due to potential common genetic and environmental underpinnings. These connections remain underexplored, particularly in the Indian context.

Assessment of IL- 35 Gene Polymorphism in Periodontitis Patients with and without Diabetes - A Cross-Sectional Study.

Aim: To evaluate the IL-35 Gene Polymorphism in Periodontitis subjects with and without type 2 diabetes mellitus.

Methodology: 96 participants were categorized into three groups, Group 1: Systemically and Periodontally healthy individuals, Group 2: Systemically healthy patients with Generalized chronic periodontitis, Group 3: Generalized chronic periodontitis with type 2 diabetes Mellitus. Genomic DNA was extracted from the whole venous blood samples collected from the participants using The PureLink Genomic Kit.

Cytotoxicity of Dhanwantharaarishtam on hiPSC Cells - An Study.

Background: Dhanwantharaarishtam is a traditional Ayurvedic herbal tonic used to improve digestion, promote lactation, and balance the Vata dosha.

Aim: The study investigates the effects of Dhanwantharaarishtam, a traditional Ayurvedic tonic, on cell viability and cytotoxicity in human induced pluripotent stem cell (hiPSC) cultures.

Methods: The impact of Dhanwantharaarishtam on hiPSC cells was analyzed over a 24 hour period.

In Silico Molecular Docking of Phytochemicals: Targeting Key Biomarkers in Oral Cancer.

Background: Oral cancer is the sixth most common cancer occurring anywhere in the globe. Cancers of the mouth are caused by tobacco and alcohol overuse, and also between pre-malignancy and full-fledged malignancy. In order to avoid the onset of illness, proper cleanliness of the mouth is important.

Antioxidant Studies of Ayurvedic Medicine, Dhanwanthararishtam.

Background: Dhanwanthararishtam is a classical Ayurvedic medicine, primarily used for postnatal care and rejuvenation.

Aim: The present study evaluates the antioxidant properties of the Ayurvedic medicine Dhanwanthararishtam, traditionally used for postnatal care to rejuvenate and strengthen the mother.

Methods: ABTS, DPPH, and FRAP, were the antibiotic assays carried out following standard protocols.

Natural wax-based edible coatings for preserving postharvest quality of mandarin orange.

Mandarin oranges are susceptible to senescence and decay, primarily due to postharvest quality loss and fungal infections. This study aim to develop edible and active coatings using carnauba and shellac incorporated with carvacrol nanoemulsion (CNE), and to examine the synergistic effects of the coating on the quality parameters and shelf-life of the mandarin oranges during ambient storage. Nanoemulsion of carvacrol with average droplet size of 348.

Nephrolepris cordifolia (L.) C.Presl Frond Micromorphology, Hydrosol Phytochemical Profiling and Antibacterial Activity against Foodborne Bacteria.

Fern species from biodiversity-rich Northeastern India are relatively underexplored. Morphological, phytochemical, and antimicrobial profiling of Nephrolepris cordifolia (L.) C.

Real-World Effectiveness and Safety of Upadacitinib in Crohn's disease: A Multi-Centre Study.

Background: We aimed to describe the real-world effectiveness and safety of upadacitinib (UPA), an oral Janus kinase 1 inhibitor (JAKi) in patients with Crohn's disease (CD).

Methods: A retrospective analysis was conducted across nine centers in the United States, focusing on adults with CD treated with UPA 45 mg as induction therapy for active luminal disease. The co-primary endpoints were clinical remission at 12 weeks (Harvey Bradshaw Index ≤ 4 or absence of symptoms on physician's global assessment) and endoscopic remission at 6 months (SEMA-CD score of 0-1 or absence of ulcers).

Estimation of Salivary Ferritin Levels in Subjects with Chronic Periodontitis with Type 2 Diabetes Mellitus.

Background: Ferritin is an iron storage protein essential for iron homeostasis regulation and an indicator of iron stores. It is an acute phase reactant and is elevated in inflammation and chronic infection. Periodontitis is a chronic inflammatory disease with periodontopathogens possessing haemolytic activity which leads to increased local iron concentration and iron disorder.

Optimized Production and Characterization of Auxin by Bacillus amyloliquefaciens (TSP11) for Plant Growth Promotion.

This study was aimed at isolating and recognizing the plant growth promoting rhizobacteria that secretes indole-3-acetic acid/auxin hormones. Among the 82 pure cultured bacterial morphotypes, the strain TSP11 showed high auxin production utilizing rice husk as a cheap substitute in the production medium. The minimal medium supplemented with 0.

Au nanoparticle-engineered TiCT MXenes as a high-performance SERS platform for detection of organic pollutants.

The detection of organic pollutants at ultra-low concentrations is crucial for environmental monitoring, yet existing surface-enhanced Raman scattering (SERS) platforms often suffer from limited sensitivity, poor stability, and inconsistent signal reproducibility. To address these challenges, this study presents a high-performance SERS platform based on in situ gold (Au) nanoparticle-engineered TiCT MXenes. This novel approach enhances signal amplification and ensures long-term stability for pollutant detection.

Enhanced and Sexually Transmitted Infections and Associated Risk Factors in Fiji Following the Coronavirus Disease 2019 Pandemic.

Background: The coronavirus disease 2019 pandemic impact on sexually transmitted infections in countries practicing syndromic management remains unknown. We conducted cross-sectional surveys in Fiji to assess increases and risk factors for (NG) and (CT) infections pre- and postpandemic.

Methods: We enrolled women, men who have sex only with women (MSW), and men who have sex with men (MSM) aged 18-40 years, collected sociodemographic/behavioral data, and tested vaginal, urethral, and rectal samples using Xpert-CT/NG.

Molecular delineation and haplotype analysis of domain membrane protein (DMP) gene influencing in-vivo haploid induction in maize.

Domain membrane protein (DMP) gene is one of the key genes regulating in vivo haploid production in maize. Here, full-length sequence (931 bp) of DMP gene was sequenced in five mutant and five wild-type maize inbreds to study allelic variation. Two SNPs viz.

piRNAs in leukemogenesis: Mechanisms, biomarkers, and therapeutic implications.

The small, non-coding RNAs known as piwi-interacting RNAs (piRNAs) serve essential roles in gene regulation by silencing transposable elements and protecting oncogenes and tumour suppressors. The production of piRNA bioactive forms uses precursor mRNAs, which team with Piwi proteins to support genome maintenance. Accurate leukaemia regulation requires piRNAs because abnormalities in these regulatory elements contribute to disease development and drug resistance progression.

Adverse Childhood Experiences in Obesity and Hypertension Among Young Adults in Delhi-NCR, India.

Objectives: Despite growing evidence linking adverse childhood experiences (ACEs) with physical health conditions such as obesity and hypertension, research in low- and middle-income countries (LMICs), including India, remains limited. This study aims to examine the relationship between ACE exposure and the risk of overweight/obesity and hypertension among young adults in Delhi-NCR, India.

Methods: The present cross-sectional study involved 1702 young adults of both sexes.

Evaluating working memory in young individuals with normal hearing through tele-assessment and traditional assessment: a comparative study.

Aim: This pilot study examined the feasibility of tele-assessment of working memory (WM) compared to conventional face-to-face assessment.

Methods: In total, 15 young adults aged between 18 and 30 years who were native speakers of Kannada with normal hearing completed three WM tests in Indian English: forward digit span, backward digit span, and n-back task through tele-assessment and in-person/face-to-face assessment. The National Aeronautics and Space Administration (NASA) task load index, which assesses subjective workload, was used to determine the difficulties across the two modes of assessment.

Phytoextracts as Natural Anti-Aging Agents: Mechanisms and Strategies for Skin Rejuvenation.

Introduction: Skin aging is a complex biological process driven by intrinsic factors, such as genetics and cellular metabolism, and extrinsic factors, including environmental stressors like UV radiation, pollution, and lifestyle choices. These factors result in visible signs of aging, such as wrinkles, reduced skin elasticity, and pigmentation.

Objective: This review presents the recent findings on phytoextracts as natural anti-aging agents, highlighting their bioactive compounds, mechanisms of action, and applications in skin rejuvenation.

Emerging Preclinical and Clinical Evidence on the Impact of Phytochemicals in Oral Cancer Metastasis.

Objective: This review focuses on the clinical and preclinical studies pertaining to the use of phytochemicals in the prevention of Oral Squamous Cell Carcinoma (OSCC) metastasis.

Methods: A thorough overview of the relevant literature was provided by the narrative review approach. The PubMed, Google Scholar, and Scopus databases were used to retrieve publications on the phytochemicals preventing oral cancer metastasis.

Systems serology analysis shows IgG1 and IgG3 memory responses six years after one dose of quadrivalent HPV vaccine.

The WHO has given a permissive recommendation for an off-label one-dose human papillomavirus (HPV) vaccine schedule to prevent cervical cancer, based on evidence of comparable protection to two or three doses of vaccine. While neutralizing antibodies are thought to be the primary mechanism of protection, the persistence of immunity and whether other antibody-mediated mechanisms of protection are involved is unclear. Using systems serology, we investigated HPV antibody responses in serum from Fijian girls who were unvaccinated or received one, two or three doses of quadrivalent HPV vaccine six years earlier.

miR-210: A non-invasive biomarker for hypoxia-driven lung cancer diagnosis and therapy.

Lung cancer is one of the major cancer-related deaths in the world due to the low success rate in invasive diagnostic procedures and late staging. Hypoxia-associated molecular signatures have received attention due to a growing demand for non-invasive prognostic biomarkers, and miR-210 has been repoured as the only viable candidate. Tumor hypoxia is a characteristic of highly malignant lung cancer, and hypoxia-inducible factors increase miR-210 in this process as a way of allowing cancer cells to inhabit low oxygen conditions and grow further in lung cancer.