Publications by authors named "Khrystyna V Duve"
Article Synopsis
- Chronic vascular encephalopathy (CVE) is a common cause of mild cognitive impairment and dementia, mainly affecting the elderly and significantly impacting their quality of life.
- CVE arises from chronic lack of blood flow to the brain (cerebral hypoperfusion), leading to insufficient oxygen, which causes hypoxia and triggers oxidative stress and neuroinflammation, creating a cycle that contributes to neurodegeneration.
- The review discusses potential treatments for CVE, emphasizing the need for research on oxidative stress and neuroinflammation, and highlights the therapeutic promise of sulforaphane and vitamin D in improving cognitive function in patients.
Objective: Aim: To access the neurological manifestations and activities of daily living in patients with encephalopathy of one of the following types: post-infectious, chronic traumatic encephalopathy, alcohol-induced, and microvascular ischemic disease of the brain.
Patients And Methods: Materials and Methods: In the period of 2021-2022 we examined 520 patients, who signed the informed consent, taking into account their age, sex, occupation, the cause, and the disease duration. Such parameters were evaluated, as the data of neurological manifestations, the activities of daily living (Barthel index), cognitive functioning (MoCA-test), and statistical methods (Statistica 13.
Objective: The aim: is to evaluate peculiarities of clinical and neurological characteristics, quality of life, brain morphometry changes and metabolic deviations of patients, who suffered from aneurysmal subarachnoid hemorrhage.
Patients And Methods: Materials and methods: In the period of 2016-2019 we examined 114 patients, who signed the informed consent, taking into account their age, clinical and anatomical form of hemorrhage, disease duration, Hunt-Hess severity grade, complications of acute period. Such parameters were evaluated, as clinical and neurological characteristics, the degree of the Barthel index and the modified Rankin scale, cognitive functioning (MoCA), psycho-emotional sphere and quality of life (HADS, SF-36), morphometric parameters based on brain computed tomography measurements, explored the indicators of apoptosis, mitochondrial dysfunction, intracellular oxidative stress.