[Induction of immunologic deficiency by benzene and its correction by administration of anabol].

Cellular immunity and activity of enzymes of xenobiotic metabolism have been investigated. It has been shown that administration of benzene induces a stable immune deficiency syndrome characterized by a decrease in the quantity if antibody-forming cells, T-killers and T-suppressors. The activity of enzymes (cytochrome P-450 and cytochrome C reductase) was also inhibited.

[Effect of T-activin on enzymes in the metabolism of xenobiotics].

Effect of T-activin on some xenobiotic metabolizing enzymes and several immunity parametres in secondary immune deficiency (subacute and chronic benzene intoxication) were investigated. T-activin was shown to regulate the xenobiotic metabolizing enzyme system. The compound decreased the enzymatic activity in subacute benzene intoxication, approaching their values up to the control level.

[Change in immunological and biochemical parameters in germ-free animals in response to T-activin].

The influence of immunoregulating humoral thymus factor T-activin (fraction AFT-6) on the activity of xenobiotic metabolism enzymes (EMX) and cellular-dependent cytotoxicity was investigated in germ-free guinea-pigs. Germ-free and conventional animals were injected 5 micrograms of T-activin intraperitoneally, on 3 successive days. The control animals were injected a physiologic saline.

[A method of sympatho-adrenalectomy in the treatment of severe forms of hypertension].

The method of operative interventions on the sympathoadrenal system proposed by the authors for the persistent hypertonic disease tolerant to pharmacotherapy results in a decrease of pressor neuroreflectory and adrenal adrenergic influences on the vascular tone. Good hypotensive effects were noted in remote postoperative terms in 81.2% of patients with the 2nd degree of the disease, and in 54.

[Expert assessment method in the prognosis of myocardial infarct in unstable stenocardia].

The questioning of highly-qualified cardiologists, using the expert assessment technique, demonstrated that 4 groups of signs could be identified in unstable angina which differed significantly (p less than 0.01) with respect to the risk of myocardial infarction. Nine of 18 signs, associated with the poorest prognosis are listed in order of significance.

[New approaches to the diagnosis of chronic bronchitis. The interrelation of functional and immunological disorders].

A subpopulation study of immunocompetent cells was carried out in 76 patients with chronic bronchitis, using monoclonal antibodies OKT 3, OKT 11, OKT 4, OKT 8, OKT 6, OKT 10, OKB 7, OKM 1, OKIa 1 and Leu 7. Detailed investigation of external respiratory and cardiovascular functions was done simultaneously. Four types of immune response were identified in relation to immunity control: individuals with a high immunoregulatory index (T helper/T suppressor ratio) due to a profound deficiency of the T suppressor subpopulation; patients with a decreased immunoregulatory index due to low quantity of T helpers; 3) patients with chronic bronchitis and normal immunoregulatory index in the presence of normal or moderately reduced quantities of T helpers and T suppressors, and 4) patients with a low immunoregulatory index due to increased T suppressor subpopulation.

[The enzyme spectrum of the peripheral blood lymphocytes in patients with nonspecific lung diseases].

The data on the activity of the enzymes of xenobiotic metabolism in peripheral blood lymphocytes point to essential disorders within the system of detoxification in patients with bronchopulmonary pathology. The necessity of cultivating cells with mitogens before measurement of the activity of the enzymes of xenobiotic metabolism of the first phase (cytochrome P-450, cytochrome C-reductase) for more precise measurement and reproducibility of the results is discussed. Study of the activity of cytosol enzymes of the second phase (glutathione-S-transferase, sulfotransferase) does not require preliminary cell cultivation.

[Prolonged peridural anesthesia with pyromecaine].

On the basis of using the home anesthetic drug promekain for prolonged peridural anesthesia in the postoperative period in 110 patients its longer analgetic effect is shown with the minimum influence upon the cardio-vascular system.