[Non-traditional view on traditional risk factors of cardiovascular diseases in seniors.].

The article reveals little-known scientific data on the traditional risk factors of cardiovascular diseases in relation to social groups of the elderly, old people and centenarians. Some of metabolism associated signs of ageing are considering. In the article some biochemical markers in seniors are evaluated (lipids, fibrinogen, uric acid etc.

[ACTIVITY ACTUAL INTESTINAL ENZYMES OF PANCREATIC ENZYMES AND ISCHEMIA OF THE SMALL INTESTINE (EXPERIMENTAL STUDY)].

The Purpose Of The Study: To study the activity of carbohydrase in model experimented on dogs.

Material And Methods: The research was carried out on 20 adult mongrel dogs of both sexes weighing from 12 before 22 kg and consisted of two series of experiments. The first one was 12 animals with 50% wrap-retirement stenosis of the celiac trunk.

[Specifics of the use of NSAIDs in senior age].

Nonsteroidal anti-inflammatory drugs (NSAIDs) have a strong analgesic and anti-inflammatory effects and are widely used in clinical practice. Patients with chronic disorders of the joints, in particular the spine, are main consumers of NSAIDs. However, risk factors for side-effects should be taken into consideration in the treatment with NSAIDs, especially in patients of old age.

[FATTY LIVER AND DEVELOPMENT OF ATHEROSCLEROSIS IN ELDERLY AND SENILE AGE].

Search for scientific information on the relation fatty liver with the development of atherosclerotic lesions of arteries. Currently fatty liver regarded as hepatic manifestation of metabolic syndrome, regardless of the presence or absence of traditional risk factors and components of metabolic syndrome, fatty liver is associated with a greater degree of atherosclerotic vascular disease. In addition fatty liver may occur long before the development of metabolic problems, thus creating preconditions for the development of possible metabolic disorders in the human body.

[Frequency of some diseases and conditions in geriatric patients with coronary heart disease and various genotypes of transcription factor 7-like 2 protein].

In 2009-2010, 98 patients diagnosed with the coronary heart disease, but without the expressed metabolic violations, decompensated conditions and diseases were surveyed. Patients of 60-90 years were divided by age into two groups: younger than 75 years--47 people; 75 years and older--51; there were 41 women and 57 men; the ratio between women and men was 1:1.4; average age was 76.

[Fatty liver in elderly patients with atherosclerotic coronary artery disease (according to autopsy data)].

In article it is a question of morphological research of fragments of tissue of a liver at 143 elderly and old patients with atherosclerosis of the coronary arteries which have died on offices of the S-Petersburg hospital for veterans of wars in 2006-2010. Average age of the died patients was defined in the range from 61 till 98 years and made 82.3 ± 1.

[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group].

Genotype and allele frequencies of uncoupling proteins 2 and 3 genes (UCP2 and UCP3) and peroxisome proliferator-activated receptors genes (PPARA, PPARD and PPARG) were studied in 206 residents of the siege and in 139 individuals of more than 69 years old (control group). Studied polymorphisms included UCP2 (Ala55Val), UCP3 (C-55T), PPARA (G/C), PPARD (+294T/C), and PPARG (Pro12Ala). The G allele and the G/G genotype (PPARA) were overrepresented in the group of survivors and C/C (UCP3) genotype prevailed in the women of besieged Leningrad compared to relevant control groups of the persons of the same age who did not suffered hungry disaster.

[Starving in childhood and diabetes mellitus in elderly age].

The long-term consequences of the protracted starvation or inadequate nutrition of children is a problem in which considerable interest has been shown in recent decades. Between June 1941 and January 1944 the civilian population of Leningrad was besieged for two and a half years. The non-combatant population of this large European city lived through lengthy periods of starvation or malnutrition against a background of additional complex stress factors (including cold, bombing, death of relatives and acquaintances, and lack of means of transport and communication).

[Peculiarities of somatic diseases in people of middle and old age survived Leningrad siege at childhood].

The results of a study on peculiarities of development of some diseases in adult peoples survived the Leningrad siege at childhood are presented. The age- and sex-related differences in an incidence and clinical features of diseases are demonstrated. More frequent incidence of severe arterial hypertension, diabetes mellitus type 2, biliar calculite disease, chronic atrophic pangastritis, terminal stage of kidney failure, more early mortality, clinically unfavorable aortal atherosclerosis development, as well as atherosclerosis of coronary, brain and carotid artheria have been revealed.

[Morphologic characteristics of lesions of the small intestinal mucosa in chronic ischemia].

The results of morphologic examination of the small bowel mucosa of 32 patients with the ischemic disease of the alimentary organs provoked by stenosis of a. iliaca are analyzed. The diagnosis was confirmed angiographically and in the course of operation.