Antitumor and adjuvant effects of phagelysates of E.coli in mice with Ehrlich carcinoma.

Aim: To augment anti-tumor host response and overcome the tumor-induced immunosuppression is of paramount importance especially when patient is subjected to radio-/chemotherapy and immune system suffers significantly. Various immunological methods have been employed as supplemental antitumor therapies. We were aimed to investigate the antitumor potential of phagelysates of gram-negative bacteria and their adjuvant effects for conventional chemotherapy in experiment.

[Application of bacterial thermo- and phagelysates for suppression of malignant tumor growth in experimental studies: 2 comparative analysis of anticancer efficacy of thermo- and phagelysates of Ps. aeruginosa and E. coli].

In the presented work antitumor effects of thermo- and phagelysates of Ps.aeruginosa and E.coli on Ehrlich carcinoma growth in mice have been studied.

[Application of bacterial thermo-and phagelysates for suppression of malignant tumor growth in experimental studies: 1. Anticancer efficacy of thermo- and phagelysates of E.coli].

Immunotherapy is considered as one of the promising treatment strategies for patients with malignant tumors. In the presented work antitumor effects of E.coli thermo- and phagelysates on Ehrlich carcinoma growth in mice have been studied.

Anti-tumor preventative effect of mono-therapy with the use of proteus vaccine, Staphylococcus antitoxin and divaccine of Staphylococcus-proteus.

Anti-tumor preventative effect of mono-therapy with the use of Proteus vaccine, Staphylococcus antitoxin and divaccine of Staphylococcus-Proteus has been studied. Experiments were carried out on 80 non-purebred laboratory white mice (age--3-3,5 months, body mass--18-20 g) and 60 rats (body mass--100-120 g) using intraperitoneal inoculation of Ehrlich's adenocarcinoma (ascitic form--EAT, in mice, cancer cells--3 x 10(6)), and subcutaneous inoculation of Sarcoma S-45 (in rats). Anti-tumor preventative effect of bacterial vaccines and immunization was evaluated according to the following parameters: Frequency of cancer development, Inhibition of cancer growth, Body mass index of experimental animals, Volume of ascitic fluid.

[Evaluation of anti-blastoma effects of tetravaccine in combination with chemotherapy].

The present work discusses methods of immune-correction and immune-rehabilitation of oncological patients using specific bacterial polyvalent vaccines. With this purpose the tetra-vaccine (Staphilococcus-Proteus-Clepsiela-Escherichia) has been used. Experiments have been carried out on white rats and mice with Sarcoma C-45.