[The differentiation factor in the bone marrow and blood serum of healthy subjects and in acute leukemia].

The factor of differentiation--i.e. systemic morphogen of connective tissue (SMCT)--have been discovered in bone marrow and blood serum of healthy humans.

[T-lymphocyte induced normalization of transformed malignant fibroblasts: lymphokine with normalization factor activity].

Normalizing influence of different lymphocyte populations and their soluble factors on L-929 transformed malignant fibroblasts (L cells) has been examined. It was demonstrated that splenic T-lymphocytes caused stable (heritable) normalization of receptor apparatus, biophysical and proliferative characteristics of L cells. Lymphokine with the activity of normalization factor (NF) was purified from 24-hour immunocyte conditioned medium.

[Detection of factors of differentiation in human malignant melanoma].

Factors of differentiation (FD) have been detected and isolated from human melanomas cloned in nude mice as well as from amphibian embryos from neurula--early tail bud stage. It has been shown that each source contains two factors of differentiation--mesodermalizing (MF) and melanogenic (MgF). Biological activity of MF has been determined by its capacity to initiate in early embryonic multipotent cells the appearance of various cell types, normally arising from mesoderm.