Publications by authors named "Khonzisizwe Somandi"
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Synopsis of recent research by authors named "Khonzisizwe Somandi"
- Khonzisizwe Somandi's recent research focuses on the development of substituted pyrimidine-2,4-diamines as potential inhibitors for Plasmodium falciparum dihydrofolate reductase (PfDHFR), which is crucial in malaria treatment.
- The study involved both in silico molecular docking studies and subsequent synthesis, showcasing the effectiveness of the compounds in inhibiting PfDHFR in vitro, with promising results against wild-type and mutant strains.
- Published in "ChemMedChem," the findings suggest that these pyrimidine-2,4-diamines have the potential to contribute to new therapeutic strategies against malaria, highlighting their viability as drug candidates.
