Hemostatic Antimicrobial Hydrogels Based on Silicon, Iron, Zinc, and Boron Glycerolates for Wound Healing Applications.

The use of glycerolates of biogenic elements as biocompatible precursors in sol-gel synthesis is an innovative direction and opens up new scientific and practical prospects in chemistry and technology of producing practically important biomedical materials, including hemostatic, antimicrobial, and wound healing materials. Using biocompatible precursors, silicon, zinc, boron, and iron glycerolates, new bioactive nanocomposite hydrogels were obtained by the sol-gel method. The composition and structural features of the hydrogels were studied using a complex of modern analytical techniques, including TEM, XRD, AES, and ESI MS.

Iron(III) Monoglycerolate as a New Biocompatible Precursor in the Synthesis of Bioactive Nanocomposite Glycerohydrogels.

Background: Nanocomposite glycerohydrogels based on biocompatible elementcontaining glycerolates are of practicular interest for biomedical applications.

Objective: Using two biocompatible precursors, silicon and iron glycerolates, a new bioactive nanocomposite silicon‒iron glycerolates hydrogel was obtained by sol-gel method.

Methods: The composition and structural features of the hydrogel were studied using a complex of modern analytical techniques, including TEM, XRD, and AES.

Magnetic Nanocomposite Materials Based on FeO Nanoparticles with Iron and Silica Glycerolates Shell: Synthesis and Characterization.

Novel magnetic nanocomposite materials based on FeO nanoparticles coated with iron and silica glycerolates (MNP@Fe(III)Glyc and MNP@Fe(III)/SiGlyc) were obtained. The synthesized nanocomposites were characterized using TEM, XRD, TGA, VMS, Mössbauer and IR spectroscopy. The amount of iron and silica glycerolates in the nanocomposites was calculated from the Mössbauer spectroscopy, ICP AES and C,H-elemental analysis.

Biocompatible Silica-Polyethylene Glycol-Based Composites for Immobilization of Microbial Cells by Sol-Gel Synthesis.

Biocatalysts based on the methylotrophic yeast VKM Y-2559 immobilized in polymer-based nanocomposites for the treatment of methanol-containing wastewater were developed. The organosilica composites with different matrix-to-filler ratios derived from TEOS/MTES in the presence of PEG (SP-composite) and from silicon-polyethylene glycol (STP-composite) differ in the structure of the silicate phase and its distribution in the composite matrix. Methods of fluorescent and scanning microscopy first confirmed the formation of an organosilica shell around living yeast cells during sol-gel bio-STP-composite synthesis.

Individual iron(iii) glycerolate: synthesis and characterisation.

Iron(ii) and iron(iii) salts of strong acids form iron glycerolates on heating at 180 °C with glycerol in the presence of an equivalent amount of alkali. Individual iron(iii) glycerolate was obtained for the first time. When FeO magnetic nanoparticles were heated with glycerol, an iron(iii) glycerolate shell was formed on their surface.

Silicon-hydroxyapatite‒glycerohydrogel as a promising biomaterial for dental applications.

Nanocomposite silicon-hydroxyapatite‒glycerohydrogel (Si-HA‒glycerohydrogel) with different hydroxyapatite (HA) contents of 0.75 and 1.75 wt.

Silicon-zinc-glycerol hydrogel, a potential immunotropic agent for topical application.

Nanoparticles synthesized using sol-gel method are promising agents for biomedical applications, in particular for the therapy and diagnosis of various diseases. Using silicon and zinc glycerolates as biocompatible precursors we synthesized by the sol-gel method a new bioactive silicon-zinc-containing glycerohydrogel combining the positive pharmacological properties of the precursors. In the present work the structural features of silicon-zinc-containing glycerohydrogel and its immunotropic properties were studied.

Features of silicon- and titanium-polyethylene glycol precursors in sol-gel synthesis of new hydrogels.

The formation of organic/inorganic hydrogels based on silicon and titanium polyethylene glycolates, new biocompatible water-soluble precursors in sol-gel processing, was investigated. The influence of different factors on the gelation process, such as excess of PEG, water molar content, pH of medium, electrolyte additives, was investigated in comparison with silicon- and titanium-glycerol precursors. The specific features of gelation for each type of precursor were revealed.

Mechanism of structural networking in hydrogels based on silicon and titanium glycerolates.

Formation of organic/inorganic hydrogels based on silicon- and titanium-glycerol precursors synthesized by transesterification of alkoxy derivatives in excess of glycerol was investigated. The precursors in excess of glycerol and obtained gels were studied by chemical and physical methods including gelation kinetics, IR spectroscopy, XRD, dynamic and electrophoretic light scattering, mechanical deformation, which disclosed the basic difference in the gelation mechanism and structure of network in the hydrogels. Due to this difference, the gelation time of silicon- and titanium-glycerol precursors depended on pH or electrolyte addition in an opposite way.