[Technique for laser activation of scleral hydropermeability in the treatment of patients with refractory forms of glaucoma].

Laser cyclodestructive interventions are considered the method of choice in the treatment of refractory glaucoma. However, the traumatic nature of cyclocoagulation makes it necessary to search for more gentle methods of laser treatment. One of the possible directions is the development of laser transscleral technologies that mainly affect the uveoscleral outflow.

[Current trends in studying pathogenesis of glaucoma].

Glaucoma is a group of neurodegenerative disorders comprising one of the main causes of irreversible blindness. Glaucoma-related blindness is a globally relevant problem. By now, many aspects of glaucoma pathogenesis have been studied: impact of increased intraocular pressure (IOP) on the development of optic neuropathy, ischemia and reperfusion of the retina, most of the direct mechanisms of neuronal death (excitotoxicity, oxidative stress, etc).

[Transscleral laser therapy in the treatment of glaucoma].

Nowadays glaucoma is one of the leading causes of irreversible blindness worldwide. The main goal in preservation of vision in glaucoma patients is reducing intraocular pressure (IOP), which is considered the main controlled risk factor for progression of glaucomatous optic neuropathy. The article discusses the effectiveness and safety of various transscleral laser technologies in the treatment of glaucoma.

Microstructural changes in sclera under thermo-mechanical effect of 1.56 µm laser radiation increasing transscleral humor outflow.

Background And Objectives: Pores in the sclera are a candidate pathway for aqueous transport and therefore can be utilized to decrease the intraocular pressure (IOP) in glaucomatous eyes. Since pore formation is a well-known mechanism for stress relaxation in solids, laser-induced creation of pores in cartilage increases hydraulic permeability and promotes tissue regeneration. The aim of this paper is to demonstrate the thermo-mechanical effect of non-destructive laser irradiation on microstructural changes in sclera, in particular pore formation, resulting in substantial increase of water permeability of eye tissues that can be a novel approach to normalize the IOP.

[The study of opportunity of aqueous humor filtration increase after nondestructive laser exposure of sclera in the site of pars plana projection (experimental study)].

Increase of scleral water permeability due to formation of porous structure after exposure of pulsed periodic radiation of erbium-glass optical fiber laser with wave length 1,56 pm was demonstrated in experimental study of cadaver human eyes in vitro and eyes of experimental animals (rabbits) in vivo. Simultaneous complex laser exposure of pars plana and ciliary processes results in summation of morphological changes that provide decrease of aqueous humor secretion, uveal drainage and extension of suprachoroid space. A base for new noninvasive technology of nondestructive laser exposure in glaucoma treatment is established.

[Laser cyclodestructive procedures in glaucoma treatment].

The history of development of cyclodestructive procedures is given, their advantages and disadvantages are discussed. Different techniques of laser use, relative and absolute contraindications to various laser cyclophotodestructive procedures are considered. Their potential complications and effecting mechanisms are discussed.