[Heat production as a criterion of adrenergic regulation of metabolic processes of the myocardium].

Bolus injection of adrenaline in coronary perfusion blood flow caused different-directed changes in coronary venous blood temperature. Directivity and myocardium heat production changes are determined by peculiarities of interactions between adrenergic and cholinergic mechanisms of cardiodynamics and myocardial metabolism regulation. Cholinergic blockade by atropine++ increases heat production and limits negative ino- and chronotropic components of cardiac adrenergic reactions.

[A method of continuous registration of heat production of the heart].

A new method of continuous registration of the cardiac heat production was developed for the quantitative assessment of the levels of metabolic processes in cardiac hemodynamic reactions. The method is based on the technique of coronary arteries catheterization and extracorporeal perfusion, coronary sinus catheterization with a special catheter equipped with miniature-temperature transducer and a device designed for transformation of blood temperature values into the electrical signals. The data on the changes in cardiac heat production during cardiovascular adrenergic reactions and in conditions of acute myocardial ischemia have been obtained.

[Regulation of coronary blood circulation].

Specifics of the basal vascular tone, the metabolic mechanisms of its regulation, the interaction among cholinergic and adrenergic nerves, transmitters, hormones and metabolic mediators in regulation of the coronary circulation, are described. The main problems and prospects are discussed.

[Changes in the function and energy metabolism of the myocardium in experimental diabetes mellitus in dogs].

Coronary arteries, coronary sinus, heart cavities, and great vessels were catheterized in anesthetized dogs with alloxan diabetes. Cardiac contractility, coronary and systemic circulation, myocardial energy metabolism and acid-base balance were studied. It was shown that the alterations of the cardiac function occurred in experimental dogs with severe diabetes mellitus.

[Effect of insulin and beta-adrenergic blockaders on coronary circulation in response to hypoxia].

An experimental study in dogs with intact thoracic cavity under morphine-chloralose narcosis featured coronary catheterization, extracorporeal perfusion and resistography as well as catheterization of the heart cavities and the coronary sinus. Hemodynamic and respiratory parameters were recorded simultaneously. PO2, PCO2 and pH were measured in the inflowing and outflowing blood.

[Effect of dopamine on coronary circulation].

The effect of dopamine on coronary and systemic circulation was examined in an experimental study on dogs using catheterization and extracorporeal perfusion of the bypassing branch of the left coronary artery, and simultaneous recording of heart's vascular resistance as well as cardio- and hemodynamic patterns. Dopamine introduced into coronary perfusion flow caused a dilatation of coronary vessels, a reflex drop in arterial blood pressure and peripheral vascular resistance, and changes in heart rate and intensity of cardiac contractions. Dopamine dosage should be about ten times as high to reproduce cardiodynamic and hemodynamic effects, comparable with the response to adrenaline and noradrenaline in terms of magnitude and pattern of development.

[Possible metabolic mechanisms of coronary circulatory disorder in an intact area of the left ventricle in experimental myocardial infarct].

In dogs with experimental myocardial infarction the anterior descending branch of the left coronary artery was ligated and 1, 2, 3, 5, and 10 days later its circumflex branch was catheterized and perfused, and coronary circulation in the intact myocardial zone, systemic hemodynamics, the AMP content and the activity of enzymes catalysing adenosine metabolism were studied. In the intact myocardial zone resistance increases in the coronary vessels and neurohumoral regulation is disturbed, the beta-adrenergic and cholinergic reactions of dilation are weakened, alpha-adrenergic pressor effect of catecholamines on the cardiac vessels is manifested, and adenosine metabolism is disturbed. Disorders of adenosine metabolism are regarded among the possible mechanisms of coronary circulatory disorders in the intact zone of the myocardium.

[Neural regulation of coronary circulation].

In anesthetized dogs, with the aid of catheterization and perfusion of the coronary arteries roith heporinesed blood, catheterization of the heart cavities, and synchronous recording of the hemodynamics in unopened thorax, the mechanisms of neural regulation of the coronary circulation were analysed. Tonic effects of the nervous system on the coronary vessels are insignificant, coronary resistance being maintained by the high basal tonus. The cholinergic and adrenergic mechaniseins interact with the more powerful metabolic mechanisms.

[Effect of insulin on coronary vessel adrenergic and cholinergic reactions].

The effect of a single insulin injection on the reaction of the coronary vessels to adrenaline, noradrenaline, and acetylcholine was studied in experiments on dogs. Insulin induces a decrease of arterial pressure and of the resistance of the coronary and peripheral vessels reduces the reflex cholinergic and beta-adrenergic reactions of dilatation of the coronary vessels, and promotes alpha-adrenergic reactions in intracoronary administration of adrenaline and noradrenaline. Insulin also weakens the immediate cholinergic reactions of the coronary vessels in stimulation of the effector systems with acetylcholine.