Study of some potential biomarkers in Egyptian hepatitis C virus patients in relation to liver disease progression and HCC.

Background: Egypt has the greatest prevalence of hepatitis C worldwide according to the WHO reports, accounting for 13% of the global HCV infections. HCV is a substantial precursor for fibrosis, cirrhosis, and hepatocellular carcinoma. This study aimed to investigate the potential relevance of some cytokines, miR-122 and miR-221 for the diagnosis of liver disease progression associated to HCV infection.

Genotyping and molecular investigation of plasmid-mediated carbapenem resistant clinical isolates in Egypt.

Unlabelled: is a multidrug-resistant nosocomial pathogen. Carbapenem resistance is mediated mainly by enzymes carried on transmissible plasmids causing their dissemination among other members of . This study aimed to molecularly detect carbapenem resistance genes in clinical isolates, genotype them using ERIC-PCR, and investigate plasmid transformation of resistant genes by using ERIC-PCR and sequencing.

Investigation of the protective and therapeutic effects of and in a breast cancer mouse model.

Introduction: The development of novel strategies for cancer therapy is crucial to improve standard treatment protocols.

Aim: This study aimed to determine the protective and therapeutic effects of heat-killed preparations of and in a breast cancer mouse model.

Methods: Forty-two female BALB/c mice (7-8 weeks old) were divided into six groups (seven mice per group).

Identifying Different Mutation Sites Leading to Resistance to the Direct-Acting Antiviral (DAA) Sofosbuvir in Hepatitis C Virus Patients from Egypt.

The hepatitis C virus (HCV) is a major global health challenge and a leading cause of morbidity and mortality. Many direct-acting antivirals (DAAs) target essential macromolecules involved in the virus' life cycle. Although such DAAs achieve great success in reducing the viral load in genotype 1 infections, other genotypes demonstrate different levels of response.

Ultra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparative and studies.

Fenticonazole nitrate (FTN) is a potent antifungal drug adopted in the treatment of vaginal candidiasis. It has inadequate aqueous solubility hence, novel ultra-deformable liposomes 'Terpesomes' (TPs) were developed that might prevail over FTN poor solubility besides TPs might abstain the obstacles of mucus invasion. TPs were assembled by thin-film hydration then optimized by Box Behnken design utilizing terpenes ratio (X), sodium deoxycholate amount (X), and ethanol concentration (X) as independent variable, whereas their impact was inspected for entrapment efficiency (Y), particle size (Y), and polydispersity index (Y).

Detection and phylogenetic analysis of in children diagnosed with acute respiratory tract infection.

Human bocavirus (HBoV) is a recently discovered parvovirus; it has been shown to be a common cause of respiratory infections and gastroenteritis in children. Since its identification, HBoV has been detected worldwide in nasopharyngeal swabs, serum and stool samples particularly those obtained from young children suffering from respiratory or gastrointestinal tract infections. The aim of this work was to determine HBoV prevalence among children with acute respiratory tract infection in Egypt, to detect the most prevalent HBoV genotype and to compare PCR and ELISA as diagnostic techniques for HBoV infection.

Prevalence and Molecular Differentiation of Entamoeba histolytica, Entamoeba dispar, Entamoeba moshkovskii, and Entamoeba hartmanni in Egypt.

Introduction: Entamoeba histolytica-caused amoebiasis is a major cause of mortality worldwide. E. histolytica is morphologically indistinguishable from nonpathogenic species like E.

Correlation of quorum sensing and virulence factors in Pseudomonas aeruginosa isolates in Egypt.

Introduction: Pseudomonas aeruginosa is one of the most virulent nosocomial pathogens worldwide. Quorum sensing (QS) regulates the production of pathogenic virulence factors and biofilm formation in P. aeruginosa.