Publications by authors named "Khodzhibekov M"

Unilateral occlusion of extracranial cerebral arteries results in asymmetric intracranial flow rate against unaffected regional tissue circulation. Multiple occlusions entail reduction of intracranial circulation even in satisfactory collateral circulation. Reduction of tissue cerebral circulation occurs in well-defined occlusive processes with decompensated collateral circulation in the absence of carbogenic vascular responses.

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A 133Xe radionuclide investigation was employed for examination of regional cerebral circulation with 5% carbogen mixture loading in patients with occlusions of the aortic arch major arteries. It was established that a positive response to carbogen mixture inhalation indicates a compensated cerebral circulation irrespective of the arterial lesion type and number. The negative vascular response is associated with uni- or bilateral reduction of the regional cerebral circulation depending on the type and severity of the arterial involvement.

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Radionuclide equilibrium ventriculography was used to examine general and regional ejection fractions and velocity characteristics for both cardiac ventricles in 28 patients with occlusions of the aortic arch branches consequent to aortic arteritis of atherosclerosis. In nonspecific aortic arteritis (NAA) even young patients have myocardial dysfunction comparable to that in the elderly with atherosclerosis. However, as shown by the nitroglycerin test, these patients preserve functional reserves of the myocardium.

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The paper is devoted to analysis of radio-diagnostic findings of 79 patients with parietal round pulmonary formations. All the patients were investigated by x-ray and ultrasound, perfusion scintigraphy of the lungs with a postural test was performed in 43 of them. Diagnostic x-ray and echographic methods were compared and evaluated in terms of defining the origin of pulmonary formations.

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The potentialities of roentgeno-endovascular dilation (RED) of various types of coarctation and aortic stenoses were studied in 12 patients aged 9 to 27. RED was performed by two Grüntzig's catheters with balloons not less than 7 mm in diameter. The main criterion of RED efficacy was a gradient of systolic pressure which was on the decrease by 25-40 mm Hg after using one catheter, and by 40-70 mm Hg after using both catheters.

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Perfusion scintigraphy of the lungs has shown that a reverse direction of postural reactions of the pulmonary blood flow is observed in patients with mitral valvular disease: perfusion of the upper lung rather than the lower lung increases. It is accounted for by the action of gravitation on capillary hydrostatic pressure resulting in the localization of interstitial edema in pulmonary venous hypertension mainly in the lower lung, its microcirculatory bed being compressed and the blood flow redistributed to the opposite upper lung. Therefore successive perfusion scintigraphy of the lungs in the vertical position and in the lateral position with a RP administered twice, can serve as a sensitive test for diagnosis of interstitial lung edema in various pathological conditions.

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The dynamics of spiroveloergometric parameters and perfusion scintigraphy of the lungs with a postural test in 129 patients with congenital heart diseases were studied before and at different terms after surgical correction of the disease. It was established that main spiroergometric parameters were improved within the period from 3 to 6 months. However, normalization of physical working ability in the group of women took place about one year later than in men.

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Under analysis are results of operative treatment of 54 patients with cirrhosis of the liver. Most satisfactory hemodynamic results were obtained after endovascular embolisation of the splenic artery as the increased general hepatic blood flow and simultaneously decreased splenic blood flow, better indices of intracardiac hemodynamics. The method of peritoneoatrial shunting is most perspective in patients with cirrhosis of the liver at the stage of decompensation of portal hypertension.

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Combined radionuclide and ultrasonic investigations (USI) were performed in 95 patients with liver cirrhosis complicated by portal hypertension. Liver and splenic shape structure and the presence of fluid in the abdominal cavity were assessed in USI. Radionuclide methods of investigation were used for determination of the hepatic blood flow, assessment of the shape, size and structure of RP distribution in the liver and spleen, and for calculation of the hepatosplenic index.

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Based on the regularity of decreasing the blood volumes from the internal edge of the lung to its periphery the authors proposed a method of gradient background correction in inhalation scintigraphy of the lungs with 133Xe. The background is detached on each image line separately for the right and left lungs. Software was developed for the implementation of this technique of background correction for any computer with a FORTRAN-IV translator.

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The authors note high significance of results of echocholescintigraphy in diagnosis of acute and chronic calculous cholecystitis. Preoperative echographic diagnosis of destructive changes in the gall bladder wall was shown to be possible.

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A scintigraphic study of the lungs in 107 patients suffering from congenital heart defects with left-to-right blood discharge has demonstrated that disorders of pulmonary flow distribution are a common finding in cases of open ductus arteriosus and interventricular septum defects. They develop due to the hemodynamic effect of shunted blood current to the pulmonary artery and intensify as pulmonary hypertension progresses. Irregular pattern of pulmonary flow affects the efficiency of gaseous exchange and determines functional severity of the disease together with pulmonary hypertension and the extent of blood discharge.

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The author shows close correlation between the degree of regional redistribution of the pulmonary blood flow using the radionuclide scintigraphy data and a mean pressure value in the left auricle and pulmonary artery in patients with mitral stenosis. In the course of disease development the index of upward-downward blood flow redistribution and the value of mean pressure in the pulmonary artery showed an increasing degree of correlation that indicated the development of the angiospastic component. A tendency to irregular growth of vascular resistance of the right and left lung was demonstrated.

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It is shown, on the basis of ventilation and perfusion scintigraphy, that marked pulmonary flow redistribution from basal to apical departments, combined with relatively normal distribution of ventilation volumes, is a regular feature of mitral stenosis combined with pulmonary hypertension. The quantitative assessment of the intensity of pulmonary perfusion redistribution can be used as a measure of pulmonary hypertension. Also, a right-to-left unbalance was established in the pulmonary flow distribution, manifested as hyperperfusion of the left lung.

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The perfusion scanning of lungs in 26 patients with Fallot's tetrad has shown disease to be accompanied in most cases by the disturbed distribution of the pulmonary blood flow. The authors have shown that its manifestations are either a unilateral deficiency of perfusion throughout one of the lungs or regional defects of perfusion restricted by part of the lung. Scanning of the lungs by I13 albumin microaggregate proved to be useful in the assessment of the degree of the intracardiac output of the venous blood into the arterial blood flow.

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