Multiple gliomas.

The authors present 2 patients. One of them had typical multifocal primary multiple synchronous wild-type IDH1/2 glioblastoma subtype RTK1, chromosome 7 duplication, homozygous CDKN2A deletion and chromosome 10 deletion. In another patient, the nature of tumors remains debatable.

[Peroxidation of serum lipids in patients with breast cancer].

Parameters of chemiluminescence of lipid peroxidation (LP), induced by hydrogen peroxide in the blood serum of oncology patients (n = 60), were examined in the process of their combined therapy. During the dynamic observations, complete correlations were found between the peculiarities of manifestations and of the clinical course of the tumor process, the level of free-radical LP and the antioxidants of blood serum. A comprehensive assessment of all mentioned indices can be used to monitor the efficiency of a conducted therapy.

[The early and subclinical forms of cerebrovascular pathology in patients with chronic ischemic heart disease].

The results of a cardioneurological follow-up enabled the authors to develop the principles of the angioneurological evaluation of patients with chronic coronary heart disease (CCHD). The survey covered 118 CCHD males aged 40-59 of functional class I and II. A differential complex of tests involving neuropathological and neuropsychological examinations, rheoencephalography with pharmacological and bicycle ergometry tests, biomicroscopy of bulbar conjunctiva allows early detection of subclinical and initial manifestations of cerebral circulatory failure (CCF) in CCHD patients.

[Use of hyperbaric oxygenation in the treatment of acute cerebrovascular disorders in ischemic heart disease].

Altogether 22 patients with concomitant cardio-cerebral acute pathology underwent all-round examinations during and after sessions of hyperbaric oxygenation (HBO). The highest clinical effect was produced by minor, substituting doses of HBO. The revealed phasic nature of the action of HBO in the treatment of patients with acute large-focal myocardial infarction and acute cerebrovascular disorders was found to be due to changes in the function of diencephalic and brain stem formations, determining the decrease of adaptation potentialities in this patients' group.

[The immediate results of the combined treatment of stage-III breast cancer].

Immediate results of complex treatment were studied in 185 patients with stage IIIa, b (T1-2N2M0 and T3N0-2M0) nodular breast cancer. Preoperative chemoradiation treatment incorporated microwave procedure. All patients had been radically mastectomized after Patey.

[Antifibrillatory effect of the calcium antagonist foridon in acute myocardial ischemia in conscious rabbits].

The effect of ryodipine on disorders of rhythm induced by occlusion of the left descending coronary artery was studied in experiments on 40 conscious immobilized rabbits. Ryodipine was injected intravenously (50 mcg/kg 5 minutes prior to and 25 mcg/kg after occlusion). Ventricular fibrillation developed in 19 (66%) rabbits of the control group and in 3 (27%) animals in the experimental group (p less than 0.

[Changes in systemic and regional hemodynamics in the acute period of myocardial infarction in conscious rabbits].

Systemic and regional hemodynamics (radioactive microspheres of 15 mcm) were studied in 7 conscious immobilized rabbits 30 min, 24 and 72 hours after left coronary artery occlusion (group 1) and 30 min and 24 hours after the occlusion in 5 rabbits who died the next day (group 2). Significant changes in myocardial blood flow, white cerebral matter and kidneys were only observed 24 h after coronary artery occlusion in group 2, simultaneously with a significant (29%) decrease in cardiac output. It is suggested that significant regional blood flow changes associated with acute experimental myocardial infarction only occurred in the presence of heart failure in rabbits.

[Cerebral hemodynamics and bioelectric activity of the brain in ischemic heart disease].

Rheoencephalographic and electroencephalographic studies were conducted in 102 male coronary patients. Mathematical amplitude-frequency analysis demonstrated symptoms of cerebral blood flow decrease and hypoxia, which were dependent on the functional class of angina for their severity.

[Status of the mnestic function of ischemic heart disease patients].

Mnemonic function was studied in 105 males with chronic coronary heart disease (CCHD). A reduced volume of memory and intensified inhibition of trace formation was observed in more than 75% of the patients. The degree of memory disorders depended on the form of the CHD course.

[Healing of meningo-cerebral wounds with a combination of plastic repair and hydrocortisone therapy under clinical and experimental conditions].

An analysis of 192 experiments has demonstrated that layer-wise plastic repair of osteal-meningeal cerebral injuries helps layer-wise reparation of individual tissues, since the implants serve as guiding membranes for the healing of individual layers of the brain and scull. Hydrocortisone therapy diminishes the development of gross collagen fibers, and causes the formation of a loose glial scar from a wide-looped network of processes of fibrill-forming astrocytes; 127 clinical observations of hydrocortisone therapy with layer-wise plastic repair of the brain and scull, followed-up for to 10 years, demonstrated that this method favours the prevention of epilepsy.