The Role of Lipids in Atherosclerosis: Focus on Molecular Biology Mechanisms and Therapeutic Approaches.

Atherosclerosis is a complex vascular disease characterized by the buildup of lipids, inflammatory cells and fibrous components in arterial walls leading to plaque formation and potential thrombotic events like myocardial infarction and strokes. Recently, there has been research on the roles of various types of lipids such as low-density lipoprotein (LDL) cholesterol, oxidized LDL (oxLDL) cholesterol and small dense LDL (sdLDL) in the onset and progression of atherosclerosis. These lipoproteins contribute to dysfunction and inflammation processes that play a role in the development and instability of plaques.

The increasing importance of novel deep eutectic solvents as potential effective antimicrobials and other medicinal properties.

With the rise of antibiotic resistance globally, coupled with evolving and emerging infectious diseases, there is an urgent need for the development of novel antimicrobials. Deep eutectic solvents (DES) are a new generation of eutectic mixtures that depict promising attributes with several biological implications. DES exhibit unique properties such as low toxicity, biodegradability, and high thermal stability.

Power-Optimal Control of a Stirling Engine's Frictional Piston Motion.

The power output of Stirling engines can be optimized by several means. In this study, the focus is on potential performance improvements that can be achieved by optimizing the piston motion of an alpha-Stirling engine in the presence of dissipative processes, in particular mechanical friction. We use a low-effort endoreversible Stirling engine model, which allows for the incorporation of finite heat and mass transfer as well as the friction caused by the piston motion.

Costs and Resource Use Among Patients with Cervical Cancer, Cervical Intraepithelial Neoplasia, and Genital Warts in Algeria.

Cervical cancer rates in North Africa have risen in the last 10 years, suggesting that this region might benefit from cervical cancer screening and HPV vaccination programs. To assess the potential benefits of cervical cancer screening and HPV vaccination in North African countries, country-specific data on the prevalence and burden of HPV-related conditions are needed. To describe the patterns and estimate the costs of management of cervical cancer, cervical intraepithelial neoplasia (CIN), and genital warts in Algeria.

Cooling Cycle Optimization for a Vuilleumier Refrigerator.

Vuilleumier refrigerators are a special type of heat-driven cooling machines. Essentially, they operate by using heat from a hot bath to pump heat from a cold bath to an environment at intermediate temperatures. In addition, some external energy in the form of electricity can be used as an auxiliary driving mechanism.

Optimized Piston Motion for an Alpha-Type Stirling Engine.

The Stirling engine is one of the most promising devices for the recovery of waste heat. Its power output can be optimized by several means, in particular by an optimized piston motion. Here, we investigate its potential performance improvements in the presence of dissipative processes.

The synergistic effect of gamma irradiation and alkaline soaking at low temperature on the pre-deacetylation of α-chitin: Optimization by design of experiment.

The effect of gamma irradiation and alkaline soaking time at low temperature (4 °C) as a pretreatment of α-chitin before its N-deacetylation and the effect temperature, NaOH concentration and the reaction time traditionally used during the deacetylation process were studied by applying a factorial experimental design. The top and bottom levels applied for each factor were 1-25 kGy for γ irradiation dose, 2-18 hours for alkaline soaking time at low temperature (4 °C), 50-85 °C for temperature, 35-60% for NaOH concentration and 30-90 min for reaction time. The measured response of deacetylation degree (DD) was determined by FTIR.

Initial-state-independent equilibration at the breakdown of the eigenstate thermalization hypothesis.

This work aims at understanding the interplay between the eigenstate thermalization hypothesis (ETH), initial state independent equilibration, and quantum chaos in systems that do not have a direct classical counterpart. It is based on numerical investigations of asymmetric Heisenberg spin ladders with varied interaction strengths between the legs, i.e.

Relevance of the eigenstate thermalization hypothesis for thermal relaxation.

We study the validity of the eigenstate thermalization hypothesis (ETH) and its role for the occurrence of initial-state independent (ISI) equilibration in closed quantum many-body systems. Using the concept of dynamical typicality, we present an extensive numerical analysis of energy exchange in integrable and nonintegrable spin-1/2 systems of large size outside the range of exact diagonalization. In the case of nonintegrable systems, our finite-size scaling shows that the ETH becomes valid in the thermodynamic limit and can serve as the underlying mechanism for ISI equilibration.

Transport in tight-binding bond percolation models.

Most of the investigations to date on tight-binding, quantum percolation models focused on the quantum percolation threshold, i.e., the analog to the Anderson transition.

Pushing the limits of the eigenstate thermalization hypothesis towards mesoscopic quantum systems.

In the ongoing discussion on thermalization in closed quantum many-body systems, the eigenstate thermalization hypothesis has recently been proposed as a universal concept and has attracted considerable attention. So far this concept is, as the name states, hypothetical. The majority of attempts to overcome this hypothetical character are based on exact diagonalization, which implies for, e.

Effect of short-range order on transport in one-particle tight-binding models.

We investigate transport properties of topologically disordered three-dimensional one-particle tight-binding models, featuring site-distance-dependent hopping terms. We start from entirely disordered systems into which we gradually introduce some short-range order by numerically performing a pertinent structural relaxation using local site-pair interactions. Transport properties of the resulting models within the delocalized regime are analyzed numerically using linear response theory.

Transport in topologically disordered one-particle, tight-binding models.

We aim at quantitatively determining transport parameters like conductivity, mean free path, etc., for simple models of spatially completely disordered quantum systems, comparable to the systems which are sometimes referred to as Lifshitz models. While some low-energy eigenstates in such models always show Anderson localization, we focus on models for which most states of the full spectrum are delocalized, i.

Oral delivery of insulin from alginate/chitosan crosslinked by glutaraldehyde.

Insulin is mainly administered via subcutaneous route by injection which is the cause of painful and possible infections. Oral insulin administration would present a more convenient form of application because it is less invasive. Oral delivery of insulin to the gastrointestinal tract is one of the most challenging issues, because it numerous barriers to overcome in order to create an effective system for insulin delivery.

Validation and substantiation of 25 kGy as sterilization dose for lyophilized human amnion membrane.

The validation and substantiation of sterilization dose for lyophilized human amnion membrane by gamma irradiation delivered by Co60 source were investigated. The validation experiments were conducted according to ISO 13409 method B. A total of 120 human amnion membranes were collected.

[Paraplegia and pregnancy: anaesthesic management].

Pregnancy is a rare occurrence in patient suffering from spinal cord lesion. The authors report the case of labour and delivery in a paraplegic patient who was suffering from lesion located T6 level. In early labour epidural analgesia was maintained and the vaginal delivery was successful without associated fluctuation of blood pressure or other signs of autonomic hyperreflexia.

Deletion mapping of chromosomal region 1p32-pter in primary breast cancer.

Distal alterations of the short arm of chromosome 1 are among the most frequent cytogenetic abnormalities in human breast carcinoma. We studied 96 primary human breast carcinomas for allelic imbalance using a panel of 31 polymorphic microsatellite, restriction fragment length polymorphism, and variable number of tandem repeat markers located mainly in the 1p32-pter region. Allelic imbalance at one or more loci was observed on the short arm of chromosome 1 in 56 (58.

Deletion mapping in breast tumor cell lines points to two distinct tumor-suppressor genes in the 1p32-pter region, one of deleted regions (1p36.2) being located within the consensus region of LOH in neuroblastoma.

Cytogenetic and molecular studies have suggested that the 1p32-pter region might contain tumor-suppressor genes involved in the pathogenesis of breast cancer and other malignancies. Isolation of these genes could be facilitated by studying tumor cell lines with well-defined deleted regions. We examined deletions on chromosome 1p in 10 breast tumor cell lines, using a panel of 36 polymorphic markers located mainly in the 1p32-pter region, that comprised microsatellite, restriction fragment length polymorphism (RFLP) and variable number of tandem repeat (VNTR) markers.

Genetic alteration mapping on chromosome 7 in primary breast cancer.

Alterations of chromosome 7 are among the most frequent cytogenetic abnormalities found in human breast carcinoma. We examined genetic changes on chromosome 7 in 113 primary human breast tumors, using both microsatellite and restriction fragment length polymorphism/variable number of tandem repeats polymorphism markers mapping to the long arm (15 markers) and the short arm (8 markers). Allelic imbalance at 1 or more loci was observed in 50 (44%) of 113 tumors on the long arm of chromosome 7 and in 41 (36%) tumors on the short arm.

Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.

To confirm several recent studies pointing to loss of heterozygosity (LOH) at BRCA2 as a prognostic factor in sporadic breast cancer, we examined this genetic alteration in a large series of human primary breast tumours for which long-term patient outcomes were known. LOH at BRCA2 correlated only with low oestrogen and progesterone receptor content. Univariate analysis of metastasis-free survival and overall survival (log-rank test) showed no link with BRCA2 status (P = 0.