Neutrophil extracellular traps characterize caseating granulomas.

Tuberculosis (TB) remains one of the top 10 causes of death worldwide and still poses a serious challenge to public health. Recent attention to neutrophils has uncovered unexplored areas demanding further investigation. Therefore, the aim of this study was to determine neutrophil activation and circulatory neutrophil extracellular trap (NET) formation in various types of TB.

New Cyclopiane Diterpenes and Polyketide Derivatives from Marine Sediment-Derived Fungus KMM 4670 and Their Biological Activities.

Two new cyclopiane diterpenes and a new cladosporin precursor, together with four known related compounds, were isolated from the marine sediment-derived fungus KMM 4670, which was re-identified based on phylogenetic inference from ITS, , , and gene regions. The absolute stereostructures of the isolated cyclopianes were determined using modified Mosher's method and quantum chemical calculations of the ECD spectra. The isolation from the natural source of two biosynthetic precursors of cladosporin from a natural source has been reported for the first time.

Neurochemical alterations of intrinsic cardiac ganglionated nerve plexus caused by arterial hypertension developed during ageing in spontaneously hypertensive and Wistar Kyoto rats.

The acknowledged hypothesis of the cause of arterial hypertension is the emerging disbalance in sympathetic and parasympathetic regulations of the cardiovascular system. This disbalance manifests in a disorder of sustainability of endogenous autonomic and sensory neural substances including calcitonin gene-related peptide (CGRP). This study aimed to examine neurochemical alterations of intrinsic cardiac ganglionated nerve plexus (GP) triggered by arterial hypertension during ageing in spontaneously hypertensive rats of juvenile (prehypertensive, 8-9 weeks), adult (early hypertensive, 12-18 weeks) and elderly (persistent hypertensive, 46-60 weeks) age in comparison with the age-matched Wistar-Kyoto rats as controls.

Cytoprotective Polyketides from Sponge-Derived Fungus .

The new polyketides lopouzanones A and B, as well as the new 1--acetyl and 2--acetyl derivatives of dendrodochol B, were isolated from the sponge-derived marine fungus strain 168CLC-57.3. Moreover, six known polyketides, gliorosein, balticolid, dendrodolide G, dihydroisocoumarine, (-)-5-methylmellein, and dendrodochol B, were identified.

[The evaluation of the external respiratory function in patients in late follow-up period after pneumonectomy].

The external respiration function (ERF) indexes were studied in 215 patients in 25-40 years after performance of pneumonectomy. In 55.3% patients ventilation indexes have exceeded the due values by 50% for two lungs, in 8.

[Origination of mediastinal hernia in late follow up period after performance of pulmonectomy].

In 25-40 years after pneumonectomy conduction the mediastinal hernia (MH) occurred in 62.4% of 210 patients. Principal clinico-radiological signs of MH were vicarious hypertrophy and true pulmonary emphysema.

[The late results of the surgical treatment of patients with tuberculosis of the intrathoracic lymph nodes].

The late follow-up results of surgical treatment of 87 patients with the intrathoracic lymph nodes tuberculosis were studied up. The follow-up have constituted from 2 to 25 years. The tuberculosis reactivation was not revealed.

[Surgical treatment of tuberculosis and nonspecific lung diseases associated with diabetes mellitus].

The results of treatment of 103 patients with tuberculosis and non-specific diseases of the lungs with concomitant diabetes mellitus were analysed. The main principles of preoperative preparation and postoperative management of the patients are presented. The incidence of operative complications was 10.