Reactive oxygen species augment contractile responses of saphenous artery in 10-15-day-old but not adult rats: Substantial role of NADPH oxidases.

Reactive oxygen species (ROS) produced by NADPH oxidases (NOX, a key source of ROS in vascular cells) are involved in the regulation of vascular tone, but this has been explored mainly for adult organisms. Importantly, the mechanisms of vascular tone regulation differ significantly in early postnatal ontogenesis and adulthood, while the vasomotor role of ROS in immature systemic arteries is poorly understood. We tested the hypothesis that the functional contribution of NADPH oxidase-derived ROS to the regulation of peripheral arterial tone is higher in the early postnatal period than in adulthood.

Perinatal hypoxia weakens anticontractile influence of NO in rat arteries during early postnatal period.

Background: Perinatal hypoxia affects a lot of neonates worldwide every year, however its effects on the functioning of systemic circulation are not clear yet. We aimed at investigation the effects of perinatal hypoxia on the second day of life on the functioning of the rat systemic vasculature in early postnatal period.

Methods: 2-day-old male rat pups were exposed to normobaric hypoxia (8% O, 92% N) for 2 hours.

[Effect of kerogen oxidation products on the biosynthesis of beta-lactamases by Escherichia coli].

Shale acid concentrate (SAC) and ozonid, the products of water-alkaline oxidation of kerogen stimulated production of beta-lactamases by E. coli. The effect was most pronounced when the SAC was added to the fermentation nutrient medium.