[The study of parathyroid hormone in the serum of patient with hypopharyngeal cancer].

Measurements of parathyroid hormone concentrations were made in the serum of patients with vestibular larynx before treatment, after radiation treatment and after radiation treatment followed by surgery. Patients with laryngeal cancer were found to have impaired calcium metabolism, their serum parathyroid hormone concentrations were elevated. After radiotherapy, in a favorable clinical course, patients with cancer of the vestibular larynx stage II show normalization of the hormone levels, whereas the above combined treatment diminished the concentrations, but they still remain above normal.

[The interrelationship of doses and the pharmacological effects of cardiac peptides].

Low-molecular weight peptides prepared according to an original procedure from a cattle heart possess a protecting effect on the myocardium during ischemia. Peptides in doses of 10(-7) g/ml and less improve the indexes of contractility function of the isolated heart after total ischemia and correct respiration warranting cardiomyocytes survival during hypoxia. However, in different models high doses of heart peptides (5 x 10(-6) g/ml and more) are shown to inhibit contractility, to stop respiration, the action of the peptides increasing with myocardial ischemia degree.

[Effect of a drug isolated from the heart on the bioenergetics of cardiomyocytes in hypoxia and ischemia].

It has been established that cordialin inhibits selectively succinic acid oxidation and intensifies the exudation of a NADH2 substrate which is energetically more advantageous, and in this way has a favorable effect on energy metabolism, evidence of which is increase of the ATP content in the myocardium. Cordialin correction of the biologic energy of cardiomyocytes in hypoxia and ischemia prevents the accumulation of lipid drops in the cells of the peri-infarction zone, which reflects the high intensity of the processes of fatty acids beta-oxidation. As a result of this glycolysis activation is unnecessary (which is confirmed by high glycogen content, both of a qualitative and quantitative character, in the myocardium and low concentrations of glucose and lactate in the blood) and, consequently, the sequelae of acidosis are prevented.

[Dynamics of various blood electrolytes in patients with Menière's disease after desiccation].

The serum concentrations of Na, K, Ca, and Cl were measured in 25 patients with Meniere's disease. In the patients with hydrops, the concentrations of K, Ca, and Cl were initially increased and during dehydration slightly decreased. In the patients without hydrops, the concentration of K and Ca was near the upper limit and that of Cl was within normal limits.

[Effects of a cardiac peptide preparation on the myocardium in ischemia].

Based on experimental studies the possibility of cordialin use in acute ischemia is being substantiated. On the first day of the animals' mortality and increased life duration of cells in ischemia zone, delaying the injury region expansion. But later in rats, that were given cordialin, slowing down of injury zone recovery and scar tissue formation was demonstrated.

[Correlations between changes in hearing and cerebral hemodynamics in patients with chronic alcoholism].

Seventy eight chronic alcoholics, aged 19 to 50 years, were exposed to audiologic and rheoencephalographic examinations. Tone hearing impairment was found in all subjects. The recruitment or greater than normal increment of loudness was primarily identified in patients of Group 1 that comprised those who consumed alcohol from 1 to 10 years.

[A simple and informative method of diagnosing myocardial infarct, based on a determination of blood density].

An increased density of blood revealed in myocardial infarction patients served the basis for a simple and highly informative method developed by the authors to early diagnose myocardial infarction when other methods are not sensitive. The high density of blood is registered upon placing a drop of blood into flakes with sodium chloride solution of different concentration.

[State of the equilibrium function in patients with chronic alcoholism].

Using stabilographic procedures and provocative tests, the present author examined 44 chronic alcoholics. He subdivided the patients into three categories--I, II and III--with respect to the stage of the disease. He detected changes in the equilibrium function which increased with the severity of the disease.

[Ultrastructure of the peri-infarction zone during treatment of experimental myocardial infarct with cardiolin].

Cardiolin therapy influence on the periinfarction zone cardiomyocyte ultrastructure, sarcolemma permeability for colloidal lantan, myocardium energy level were studied in 25 white noninbred rats with experimental myocardial infarction. 6 hours after coronary occlusion ultrastructural damage in treated rats was less pronounced and mitochondria energy efficiency ratio was higher than those in the control group. 24 hours after the occlusion the tendency to normalization of the cardiomyocyte damage in treated rat myocardium was demonstrated, while in non-treated animals ischemic damage becomes irreversible, this being confirmed by the test with colloidal lantan.

[Ultrastructure of cardiomyocytes in the peri-infarct zone during the treatment of experimental myocardial infarct in rats using the hexapeptide dalargin].

The experiments on white rats with induced myocardial infarction have studied the influence of dalargin on the infarction size and peri-infarction zone ultrastructure. 24 hours later the decrease in the infarction zone size was detected in rats who had received dalargin in a dose of 50 and 100 micrograms/kg. In the peri-infarction zone the increase in glycogen quantity, the lower degree of lipid infiltration, the increase in mitochondrial number and mitochondrial energy effectiveness coefficient were noted, as compared to control animals.

[Changes in the biochemical and morphological indices of structural disturbance in the peri-infarct area of the myocardium as affected by opioid peptides in an experiment].

The effect of opiate peptides (leu-enkephalin, met-enkephalin and beta-endorphin) as well as of enkephalin synthetic analogs (two tetrapeptides and dalargin hexapeptide) on the activity of blood enzymes CPK and LDG1, the scope of myocardial infarction and ultrastructure of periinfarction cardiomyocytes has been studied on 200 white outbred rats with simulated myocardial infarction. The endogenous opiate peptides and dalargin hexapeptide were found to significantly decrease CPK and LDG1 activity and to diminish the size of the infarction. The effect is related to the drugs influence on the survival of periinfarction cardiomyocytes that can be proved electron-microscopically and using colloid lanthanum test.

The role of enkephalins in the pathogenesis of acute myocardial infarction.

Finding opiate receptors in the heart, definition of their role in contractility and blood flow regulation (2) as well as our previous data on the decrease of Leu-enkephalins contents in the blood of patients with myocardial infarction (5) are the theoretical prerequisites for the elucidation of the role of Leu-enkephalins in the pathogenesis of acute myocardial infarction.

[Fragments of gas dynamic parameters of pulsatile diffusion respiration].

The fragments of the mathematical simulation of one of the present-day methods of artificial pulmonary ventilation (APV) are described. Some parameters of this APV method have been calculated on the basis of the anatomic and physiologic data and the gas dynamic methods.

[Ultrastructure of the sinus and atrioventricular nodes in experimental myocardial infarct].

The ultrastructure of sinus and atrioventricular nodes was studied in white rats with experimental myocardial infarction. 24 hours after the induction of the disease mitochondrial enlargement characterized by the increase in their area, decrease in the number of cristae and the decline in the rate of mitochondrial energy effectiveness was detected. Different degrees of nuclear chromatin aggregation and membrane permeability for colloidal lanthanum were observed.