SARS-CoV-2, platelets, and endothelium: coexistence in space and time, or a pernicious ménage à trois?

As we enter year 3 of SARS-CoV-2 pandemic, long-term consequences of COVID-19 have become a major public health issue worldwide; however, the molecular and cellular underpinnings of 'long COVID' remain very poorly understood. A paradigm has recently emerged that thrombo-inflammatory consequences of SARS-CoV-2's impact on endothelial cells and platelets likely play a significant role in the development of chronic symptomatology associated with COVID-19. In this brief overview, we discuss the recent findings pertaining to the detection of SARS-CoV-2 virions in vascular cell subtypes, the contribution of the coagulation system to the development of 'long COVID', and the potential role of stem/progenitor cells in the viral and thrombotic dissemination in this disorder.

[Blood pressure profile in patients with hyper- and hypotension: effect of physiological stresses].

Responses to physiological stresses, relationship between character and severity of these reactions and parameters of 24-hour blood pressure (BP) profile were studied in patients with arterial hyper- and hypotension. Disturbed regulation of BP in hyper-, and hypotension was associated not only with pronounced spontaneous BP variability but also with hyper- and hypotensive responses of BP to natural and modeled orthostatic, psychoemotional, physical and nutritional stresses. Frequency of hypotensive episodes in patients with hypertension was similar to that of hypertensive episodes in patients with hypotension.

Pulsometric study of the functional state of cardiovascular system under conditions provoking neurogenic syncopes.

The effects of passive and active orthostatic loads on the amplitude and temporal parameters of pulse waves were studied using an original computer assisted method of differential sphygmomanometry. Changes in the cardiac rhythm reflecting impairment of the autonomic regulation of the circulatory system and preceding neurogenic cardiovascular syncope were revealed and evaluated. Comparative analysis revealed similarity between these changes under conditions of both passive and active orthostasis, which confirmed the diagnostic value of differential sphygmomanometry.

[Efficacy of OSMO-Adalat in patients with arterial hypertension in combination with kinked precerebral arteries].

Aim: To evaluate effectiveness of OSMO-adalat in combination of arterial hypertension (AH) with kinked precerebral arteries (KPA).

Material And Methods: Before and after a 3-month course of OSMO-Adalat in a dose 30 and 60 mg, 28 patients with AH (degree 2-3) and KPA were examined for arterial pressure (AP), dyscirculatory encephalopathy, orthostatic stability, ischemic heart disease, transitory ischemic attacks, side effects of therapy.

Results: A complete normalization of AP was achieved in 9(32.

[Modelling of myocardial hypertrophy in vitro for solving problems of medicinal correction].

The work has been done on primary heart culture from neonatal rat ventricle. Cardiomyocyte hypertrophy was modelled using noradrenaline (NA), angiotensin II (AII) and fetal serum, respectively. Cell hypertrophy of primary heart cultures was assessed by measuring the surface area, the scope of protein synthesis estimated by 3H-leucine autoradiography and the contents of nucleic acids in gallocyanin-chromalum stained cardiomyocytes.

[Comparative study of the level of cardiomyocyte hypertrophy in patients suffering from ischemic heart disease with normal arterial pressure and in hypertension].

A study was performed on the human atrial myocytes, isolated by means of alkaline dissociation of bioptates, obtained in clinics during open heart surgery, from two groups of patients. The first group consisted of 8 men aged from 40 to 62 years, with ischemic heart disease and normal arterial blood pressure. The second group involved 10 men, aged from 43 to 67 years, with ischemic heart disease and arterial hypertension.

[Changes in the cytochemical and morphometric characteristics of the myocytes in the right heart of the rat in adrenal-regeneration hypertension].

A study was made on myocytes of the right atrium and the right ventricle of rats with experimental arterial hypertension due to adrenal regeneration. The nuclear DNA and the total protein in the cytoplasm were revealed using two consecutive tests: the Feulgen reaction and Napththol yellow S staining. A two-wavelength scanning cytophotometry was used for measuring DNA and protein contents.

[The effect of adrenal-regeneration hypertension on protein-nucleic acid metabolism in rat atrial cardiomyocytes].

A study was made on cardiomyocytes of the left atrium of rats with experimental arterial hypertension due to adrenal regeneration. The nuclear DNA and the total protein in the cytoplasm were revealed using two consecutive tests: the Feulgen reaction, and Naphthol yellow S staining. The two-wavelength scanning cytophotometry was used for measuring DNA and protein contents.

[Changes in the concentration of atrial hormone in hypertensive crises].

The paper presents concentrations of atrial sodium-uretic hormone (AH) in the plasma of hypertensive subjects during a hypertensive crisis and in stable blood pressure, in healthy subjects (12, 19 and 7 females, respectively). AH levels were the highest in hypertensives in the crisis. Mean AH concentrations in the crisis and short after the pressure normalization did not differ much.

Atrial and digitalis-like natriuretic hormones in essential hypertension under functional loading.

To assess the relation of the two natriuretic hormones, atrial natriuretic peptide (ANP) and digitalis-like natriuretic factor (DLF), to hypertension, levels of ANP and DLF were measured under basal conditions and after salt and water loading in 31 normal subjects and 36 and 57 patients with Stage I or II essential hypertension (EH). DLF levels were higher in normal women than men; in EH-II patients, DLF levels were elevated among men but subnormal in women (P less than .02) and rose with water loading in both genders.

[Natriuretic hormones (atrial and digitalis-like) in patients with arterial hypertension during exercise].

Blood levels of natriuretic hormones (atrial natriuretic peptide and digitalis-like natriuretic factor) were measured in 93 patients with Stages I and II essential hypertension and 31 healthy individuals. The baseline level of digitalis-like natriuretic factor was higher in the patients with Stage II essential hypertension than in the healthy individuals. This parameter was normal in the patients with Stage I hypertension.