Publications by authors named "Khine Lin"
Article Synopsis
- * A deep-learning model can predict allele-specific activity using only local nucleotide sequences, emphasizing key transcription-factor-binding motifs affected by genetic variants.
- * Combining EN-TEx with previous genome annotations shows significant connections between allele-specific loci and GWAS loci, and aids in transferring known eQTLs to challenging tissue types, improving personal functional genomics research.
The Encyclopedia of DNA Elements (ENCODE) web portal hosts genomic data generated by the ENCODE Consortium, Genomics of Gene Regulation, The NIH Roadmap Epigenomics Consortium, and the modENCODE and modERN projects. The goal of the ENCODE project is to build a comprehensive map of the functional elements of the human and mouse genomes. Currently, the portal database stores over 500 TB of raw and processed data from over 15,000 experiments spanning assays that measure gene expression, DNA accessibility, DNA and RNA binding, DNA methylation, and 3D chromatin structure across numerous cell lines, tissue types, and differentiation states with selected genetic and molecular perturbations.
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- The Encyclopedia of DNA Elements (ENCODE) is an ongoing research project focused on identifying functional elements in human and mouse genomes.
- The ENCODE portal offers free access to data and has been continuously updated since its launch in 2013 to enhance usability and accessibility.
- Recent updates include new data, improved processing pipelines, visualization tools, a dataset cart feature, and expanded resources available through cloud services.