High resolution Thomson scattering diagnostic for measurements of radial profiles of electron temperature and density in the gas dynamic trap.

The incoherent Thomson scattering diagnostic with multiple lines of sight is installed at the gas dynamic trap (GDT) for measurements of radial profiles of the plasma electron temperature and density. The diagnostic is built on the Nd:YAG laser operating at 1064 nm. The laser input beamline is provided with an automatic system for alignment status monitoring and correction.

Note: Spectrometer with multichannel photon-counting detector for beam emission spectroscopy in magnetic fusion devices.

A spectrometer based on a linear array photomultiplier tube (PMT) has been developed and calibrated. A 0.635 m focal length Czerny-Turner monochromator combined with a coupling optics provides an image of a narrow 0.

Development of a multichannel dispersion interferometer at TEXTOR.

The design and main characteristics of 14-channel dispersion interferometer for plasma profile measurement and control in TEXTOR tokamak are presented. The diagnostic is engineered on the basis of modular concept, the 10.6 microm CO(2) laser source and all optical and mechanical elements of each module are arranged in a compact housing.

[LDL oxidation and uptake by monocyte-derived macrophages from blood of patients with ischemic heart disease].

The aim of this study was to test our hypothesis that monocyte-derived macrophages of patients with ischemic heart diseases (IHD, MPIHD) were prestimulated (primed) or stimulated cells whose capacity for LDL oxidation and uptake exceeded that ofmacrophages from healthy donors (MPN). Monocytes were obtained from the blood of 18 healthy donors and 25 IHD patients; plasma LDL--from 16 another group healthy donors (LDLN) and 15 patients with family hypercholesterolemia. Incubation of LDLN or LDLH with MPIHD or MPN was carried out under aerobic and hypoxic conditions.

First experimental results from 2 MeV proton tandem accelerator for neutron production.

A 2 MeV proton tandem accelerator with vacuum insulation was developed and first experiments are carried out in the Budker Institute of Nuclear Physics (Novosibirsk). The accelerator is designed for neutron production via reaction (7)Li(p,n)(7)Be for the boron neutron-capture therapy of the brain tumors, and for explosive detection based on 9.1724 MeV resonance gamma, which are produced via reaction (13)C(p,gamma)(14)N, absorption in nitrogen.

Direct current H(-) source for boron neutron capture therapy tandem accelerator.

One year experience of dc H(-) source operation at 2 MeV tandem accelerator is described. The source delivers H(-) ion beams with controlled current in the range of 1-8 mA and energy up to 25 keV. Normalized 1 rms emittance for 8 mA beam is less than 0.

New fast beam profile monitor for electron-positron colliders.

A new fast beam profile monitor has been developed at the Budker Institute of Nuclear Physics. This monitor is based on the Hamamatsu multianode photomultiplier with 16 anode strips and provides turn-by-turn measurement of the transverse beam profile. The device is equipped with an internal memory, which has enough capacity to store 131,072 samples of the beam profile.

[The use of antioxidants and antihypoxants for decreasing of LDL oxidation by macrophages and endothelial cells in ischemia and reperfusion of vascular wall].

Oxidative modification of LDL is a key factor in pathogenesis of atheroslerosis. In this work the effects of antioxidants (K-phenosan, probucol, and desferal) and antihypoxants (succinic acid, hypoxen, and deltaran) on the macrophage- and endothelial cell-mediated oxidation of LDL was studied. Electrophoretic mobility of LDL, the content of lipid peroxide products (TBARS and diene conjugates, DC) and cell viability were used as the indexes of LDL oxidation.

Effect of antioxidant probucol on cell-mediated LDL oxidation in vitro and in vivo.

We studied the effect of phenol antioxidant probucol on free radical oxidation of LDL isolated from blood plasma of healthy donors. Oxidation was induced by co-incubation of LDL with cultured peripheral blood monocyte-macrophages and human umbilical vein endothelial cells under conditions of ischemia-reperfusion. In addition, the effect of probucol therapy on oxidability of plasma LDL in CHD patients was examined.

Tumor necrosis factor-alpha in low doses preactivates and activates macrophages by increasing their ability to produce reactive oxygen species and oxidize low-density lipoproteins: protective effect of antioxidants.

Tumor necrosis factor-alpha in low doses activated rat peritoneal macrophages and intensified production of reactive oxygen species (zymosan-depended chemiluminescence). Single or 2-fold incubation with tumor necrosis factor-a activated and preactivated human blood macrophages and promoted oxidative modification of low-density lipoproteins (increased their mobility in agarose gel). Antioxidants (potassium phenosan, probucol, and desferal) suppressed oxidative modification of low-density lipoproteins induced by nonactivated, preactivated, and activated macrophages.